• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Protective effect of phosphoenolpyruvate on acute lung injury

Research Project

Project/Area Number 22591729
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTottori University

Principal Investigator

OSHIMA Yoshiaki  鳥取大学, 医学部, 准教授 (90233105)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords周術期管理学 / Phosphoenolpyruvate / 摘出灌流肺標本 / ウサギ / 虚血再灌流障害肺 / 肺濾過係数 / 肺の湿乾重量比 / ピルビン酸 / 乳酸 / 解糖系中間代謝産物 / ホスホエノールピルビン酸 / 虚血再灌流肺障害 / 摘出灌流肺 / 濾過係数 / 肺湿乾重量比
Research Abstract

Phosphoenolpyruvate (PEP) is an endogenous substance that is one of the ATP precursors and can cross some cell membranes via anion exchanger. We investigated the effects of PEP on ischemia/reperfusion (IR)-induced lung injury. Isolated rabbit lungs were divided into the following groups: control (n=6), perfused and ventilated without ischemia; IR (n=6), ischemia for 60min, followed by reperfusion; PEP-IR (n=6), 1mM PEP was administered for 30min before ischemia, followed by IR. The administration of PEP before ischemia significantly attenuated the increases in IR-induced coefficient of filtration and wet to dry ratio, and caused the increase in pyruvate in the perfusate.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2013 2012

All Presentation (4 results)

  • [Presentation] Desfluraneの虚血前吸入はウサギ摘出肺において肺虚血再灌流障害を増強する2013

    • Author(s)
      大嶋嘉明、倉敷達之、原田知実、青木亜紀、仲宗根正人、稲垣喜三
    • Organizer
      第60回日本麻酔科学会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Final Research Report
  • [Presentation] デスフルレンは虚血再灌流障害肺を増強する2013

    • Author(s)
      大嶋 嘉明
    • Organizer
      第60回日本麻酔科学会(発表確定)
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウサギ虚血再灌流障害肺に対するホスホエノールピルビン酸の保護効果2012

    • Author(s)
      大嶋 嘉明、稲垣 喜三、坂本成司、船越多恵、持田晋輔、遠藤 涼
    • Organizer
      第59回日本麻酔科学会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2012 Final Research Report
  • [Presentation] ウサギ虚血再灌流障害肺に対するホスホエノールピルビン酸の保護効果2012

    • Author(s)
      大嶋 嘉明
    • Organizer
      第59回日本麻酔科学会
    • Place of Presentation
      神戸ポートピアホテル(神戸)
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi