Protective effect of phosphoenolpyruvate on acute lung injury
| Project/Area Number |
22591729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 周術期管理学 / Phosphoenolpyruvate / 摘出灌流肺標本 / ウサギ / 虚血再灌流障害肺 / 肺濾過係数 / 肺の湿乾重量比 / ピルビン酸 / 乳酸 / 解糖系中間代謝産物 / ホスホエノールピルビン酸 / 虚血再灌流肺障害 / 摘出灌流肺 / 濾過係数 / 肺湿乾重量比 |
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| Research Abstract |
Phosphoenolpyruvate (PEP) is an endogenous substance that is one of the ATP precursors and can cross some cell membranes via anion exchanger. We investigated the effects of PEP on ischemia/reperfusion (IR)-induced lung injury. Isolated rabbit lungs were divided into the following groups: control (n=6), perfused and ventilated without ischemia; IR (n=6), ischemia for 60min, followed by reperfusion; PEP-IR (n=6), 1mM PEP was administered for 30min before ischemia, followed by IR. The administration of PEP before ischemia significantly attenuated the increases in IR-induced coefficient of filtration and wet to dry ratio, and caused the increase in pyruvate in the perfusate.
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Report
(4 results)
Research Products
(4 results)
