| Project/Area Number |
22591731
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
GOTO Keiji 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00234980)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OTO Takahiko 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (40452578)
MIZOBUCHI Satosi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70311800)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
|
|---|
| Keywords | 周術期管理学 / 肺移植 / グラフト機能不全 / 炎症性メディエーター / 炎症性メディエータ |
|---|
| Research Abstract |
We performed twenty-eight lung transplantations (brain-dead lung transplant: 20 patients, living-donor lober lung transplant: 8 patients) for 3 years in Okayama University Hospital. All patients survived. Owing to our improvements in surgical technique, anesthesia, and postoperative management, no early graft failure developed. Serum levels of interleukin-6 and polymorphonuclear elastase increased during and after cardiopulmonary bypass, but there was no significant change in serum level of these inflammatory cytokines after lung transplantation.
|
