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Evaluation of the analgesic effect of new compounds DHLHZN onadjuvant-induced pain in the rat

Research Project

Project/Area Number 22591739
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOita University

Principal Investigator

TAKESHIMA Naozumi  大分大学, 医学部, 客員研究員 (40305058)

Co-Investigator(Kenkyū-buntansha) TAKATANI Juniji  大分大学, 医学部, 助教 (50537107)
OKUDA Kentaro  大分大学, 医学部, 講師 (60284808)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords抗酸化物質 / 亜急性疼痛 / 鎮痛効果 / αリポ酸 / フリーラジカル / 疼痛管理学 / 抗酸化物 / 新規化合物DHLHZn
Research Abstract

It was found that fewer side effects where use adjuvant-induced pain model in the rat, was administered subcutaneously daily to DHLHZN. Because that withdrawal latency by plantar test increased, infiltration of inflammatory cells was inhibited, the tissue MPO(Myeloperoxidase) concentration decreased, likely to have analgesic effect of DHLHZN by anti-inflammatory action was suggested. Next, we examined DHLHZN whether having an analgesic effect in dose-dependency, whether having an analgesic effect in after the administration subcutaneously, but was not proven.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Presentation (2 results)

  • [Presentation] ラット疼痛モデルにおける新規抗酸化化合物 DHLHZN の鎮痛効果の検討2010

    • Author(s)
      竹島直純
    • Organizer
      日本ペインクリニック学会第44回大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-07-03
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット疼痛モデルにおける新規抗酸化化合物DHLHZnの鎮痛効果の検討.2010

    • Author(s)
      竹島直純、萩原聡、高谷純司、奥田健太郎、野口隆之
    • Organizer
      日本ペインクリニック学会第44回大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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