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Effect site of spinal cord stimulation for refractory pain -central or peripheral-

Research Project

Project/Area Number 22591743
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionYokohama City University

Principal Investigator

SHINBORI Hironobu  横浜市立大学, 医学部, 講師 (60404993)

Co-Investigator(Kenkyū-buntansha) OGAWA Kenichi  横浜市立大学, 附属病院, 准教授 (10233412)
KAMIYA Yoshinori  横浜市立大学, 医学研究科, 客員講師 (90381491)
KIKUCHI Tatsuaki  横浜市立大学, 医学研究科, 客員准教授 (70285138)
TAZAWA Toshiharu  横浜市立大学, 医学研究科, 客員研究員 (40405006)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords難治性疼痛 / 脊髄刺激鎮痛法 / 下降性抑制系 / 神経因性疼痛 / 下降性疼痛抑制系 / 疼痛行動 / 免疫組織学研究 / マイクロダイアリシス法
Research Abstract

In this study, we found that the analgesic effect of spinal cord stimulation is attenuated by inhibiting noradrenaline and serotonin, a neurotransmitter of the descending inhibitory system in the spinal cord. In addition, by spinal cord stimulation, the number of serotonergic neurons in the dorsal raphe nucleus was increased and the increased staining intensity against noradrenaline synthase at locus coeruleus of injured side in neuropathic pain model rats was returned to its original level. Moreover, we made it clear that the expression level of noradrenaline and serotonin synthetic enzyme of the dorsal horn does not change by spinal cord stimulation. These observations indicated that antinociceptive action of spinal cord stimulation might be mediated by the activation of the descending inhibitory system.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(6 results)

All 2012 2011 Other

All Presentation (6 results)

  • [Presentation] SPINAL CORD STIMULATION ENHANCES PHOSPHORYLATION OF CREB PROTEIN AND NUMBER OF THE SEROTONERGIC NEURONS IN DORSAL RAPHE OF NEUROPATHIC ANIMALS2012

    • Author(s)
      Toshiharu Tazawa, Yoshinori Kamiya,Ayako Kobayashi, Kensuke Saeki, Hironobu Shinbori, Kengo Funakoshi, Takahisa Goto
    • Organizer
      Annual Meeting of International Association of Study for Pain
    • Place of Presentation
      ミラノ(イタリア)
    • Year and Date
      2012-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Pharmacological Analysis for the5-HT Receptors in Electrical Spinal Cord Stimulation for Neuropathic Pain in Rat2011

    • Author(s)
      Ayako Kobayashi, Yoshinori Kamiya, Toshiharu Tazawa, Takahiro Mihara, Yusuke Nakahashi, Hironobu Shinbori, Takahisa Goto
    • Organizer
      Anesthesiology 2011
    • Place of Presentation
      シカゴ(アメリカ合衆国)
    • Year and Date
      2011-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Pharmacological Analysis for the 5-HT Receptors in Electrical Spinal Cord Stimulation for Neuropathic Pain in Rat2011

    • Author(s)
      Yoshinori Kamiya, Ayako Kobayashi, Toshiharu Tazawa, et.al.
    • Organizer
      Anesthesiology 2011
    • Place of Presentation
      シカゴマコーミックプレイス(米国イリノイ州)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脊髄電気刺激の鎮痛効果は、5-HT、α2 受容体の活性化を介する2011

    • Author(s)
      小林綾子, 田澤利治, 中橋勇典, 紙谷義孝, 後藤隆久
    • Organizer
      日本麻酔科学会第58回学術集会.
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄電気刺激の鎮痛効果は、5-HT・α2受容体の活性化を介する2011

    • Author(s)
      小林綾子, 田澤利治, 中橋勇典, 紙谷義孝, 後藤隆久
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Funakoshi, Takahisa Goto: SPINAL CORD STIMULATION ENHANCES PHOSPHORYLATION OF CREB PROTEIN AND NUMBER OF THE SEROTONERGIC NEURONS IN DORSAL RAPHE OF NEUROPATHIC ANIMALS.

    • Author(s)
      Toshiharu Tazawa, Yoshinori Kamiya, Ayako Kobayashi, Kensuke Saeki, Hironobu Shinbori, Kengo Funakoshi, Takahisa Goto
    • Organizer
      The 14th World Congress on Pain (Milan2012),
    • Place of Presentation
      Milano, Italy
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-22   Modified: 2019-07-29  

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