A clinical study to investigate effects of various genomic single nucleotide polymorphisms (SNPs) on analgesic and adverse effects of opioid analgesics
| Project/Area Number |
22591747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Juntendo University (2011-2012)
Saitama Medical University (2010) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Shigeki 埼玉医科大学, 医学部, 教授 (30254220)
IKEDA Kazutaka 東京都医学総合研究所, 参事研究員 (60281656)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 遺伝子多型 / 麻薬 / オピオイド / 術後痛 / 神経障害性疼痛 / 疼痛管理 / 麻薬感受性 / 麻薬必要量 / 麻薬副作用 / オピオイド受容体 / 疼痛管理学 / 手術痛 / 難治性慢性疼痛 / 疼痛感受性 |
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| Research Abstract |
In the current study, we reconfirmed that a single nucleotide polymorphism (SNP), 118A/G of the human μ -opioid receptor gene decreased opioid sensitivity and increased postoperative opioid requirements. We also found that genetic polymorphisms within a linkage disequilibrium block that spans 2q33.3 -2q34 were strongly associated with postoperative opioid requirements. The C allele of the SNP, rs2952768, was associated with more analgesic requirements. In addition, carriers of the C allele in this SNP exhibited less vulnerability to severe drug dependence. Our findings provide valuable information for the personalized treatment of pain and drug dependence.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Genome-wide association study identifies a potent locus associated with human opioid sensitivity.2014
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K.
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Journal Title
Mol Psychiatry
Volume: 19(1)
Issue: 1
Pages: 55-62
DOI
Related Report
Peer Reviewed
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[Journal Article] Genome-wide association study identifies a potent locus associated with human opioid sensitivity2012
Author(s)
Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K
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Journal Title
Mol Psychiatry
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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