| Project/Area Number |
22591750
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KONDO Ichiro 東京慈恵会医科大学, 医学部, 准教授 (50266623)
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| Co-Investigator(Kenkyū-buntansha) |
NAGANUMA Keiko 東京慈恵会医科大学, 医学部, 助教 (70277086)
FUJIGASAKI Jyunko 東京慈恵会医科大学, 医学部, 講師 (60312021)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 癌性疼痛 / モルヒネ / 髄腔内投与 / 鎮痛耐性 / 脊髄肉芽腫 / 肉芽形成 / 脊髄鎮痛 |
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| Research Abstract |
Analgesic doses of IT morphine and IT DEX infusion produce tolerance. Co-administration of low doses of IT DEX with IT morphine has significant analgesia without tolerance. Severe impression of the spinal cord along the course of the catheter indicating granuloma formation could be seen in morphine infusion animals. Addition of low dose of IT DEX inhibits IT morphine infusion-induced granuloma formation followed by motor impairment. However, IT DEX and morphine provided a littleanalgesic effects in a rat model of cancer induced bone pain. Development of tolerance and granuloma formation followed by motor impairment induced by chronic IT morphine were inhibited by addition of DEX. Combination of IT morphine and DEX may contribute to patients with chronic cancer pain to avoid side effects.
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