The mechanisms of immunosuppression and organ dysfunctions following surgical stress and its modulation.
Project/Area Number |
22591755
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kohji 産業医科大学, 医学部, 非常勤医師 (50248572)
SATA Takeyoshi 産業医科大学, 医学部, 教授 (60128030)
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Co-Investigator(Renkei-kenkyūsha) |
UEKI Masaya 産業医科大学, 医学部, 助教 (40534144)
HABE Kazutoshi 産業医科大学, 医学部, 助教 (50534145)
HAMADA Kohtaro 産業医科大学, 医学部, 助教 (70461580)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 外科的侵襲 / 臓器障害 / トロンボモジュリン / 合併症 / 外科侵襲 / サイトカイン / HMGB1 |
Research Abstract |
The purposes of this study were to investigate the mechanisms of surgical stress induced immunosupPression and organ dysfunction and to develop the strategy of its regulation. After trauma-hemorrhage (T-H), plasma levels of TNF-α, IL-6, and HMGBl increased. Plasma AST and ALT concentrations also increased after T-H. Thrombomodulin (TM) treated improved plasma cytokines and HMGBl concentrations. Liver injury also improved. TM may be a beneficial treatment for surgical stressed patients.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Thrombosis from a prothrombin mutation conveying antithrombin resistance.2012
Author(s)
Miyawaki Y, Suzuki A, Fujita J, Maki A, Okuyama E, Murata M, Takagi A, Murate T, Kunishima S, Sakai M, Okamoto K, Matsushita T, Naoe T, Saito H, Kojima T
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Journal Title
N Engl J Med.
Volume: 366
Issue: 25
Pages: 2390-2396
DOI
Related Report
Peer Reviewed
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