| Project/Area Number |
22591760
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
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| Research Field |
Urology
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
ARAI Seiji 群馬大学, 大学院・医学系研究科, 大学院生
鈴木 慶二 群馬大学, 名誉教授
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
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| Keywords | 前立腺癌 / エストロゲン / アンドロゲン / 脂肪組織 / ホルモン代謝 / ホルモン / 代謝 / 前立腺 / 組織 / 脂肪 / 組織内 / ステロイドホルモン |
|---|
| Research Abstract |
The concentration of estrogen in the prostate tissue was very little, that it was difficult to determine it even with a newly developed ultra-sensitive analytical method utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS). Steroid hormones including active androgens and androgen-synthetic enzyme activity were demonstrated in human adipose tissue. These results suggest that adipose tissue may be another source of androgen synthesis in prostate cancer and may be related to the development of CRPC by stimulating androgen receptor-bearing cancer cells, which become hypersensitive to its ligand.
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