Molecular mechanism of hormone-independent progression of prostatecancer: Its clinical application to personalized medicine
Project/Area Number |
22591761
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Toho University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 前立腺癌 / ホルモン療法 / 去勢抵抗性 / 骨転移 / バイオマーカー / osteoprotegerin / RANK / RANKL / ノモグラム / ゾレドロン酸 / アンドロゲン / アンドロゲン受容体 / 重粒子線 / ステロイド / センダイウイルス / 骨代謝マーカー / メタボリック症候群 |
Research Abstract |
In order to clarify molecular mechanism of hormone-independent progression of prostate cancer, metastatic and/or castration-resistant prostate cancer cases were analyzed by clinical and/or molecular approaches. From these results, some molecular pathway of this process were investigated and new biomarkers were developed. Especially, we reported that OPG-RANK-RANKL pathway is found to be useful for predicting prognosis and Zoledronic acid, a bone modifying agent, has anti-tumor effect on metastatic prostate cancer cases. Also, wefound anti-tumor effect of dendritic cells induced by Sndai virus vector in rat prostate cancer model.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Analysis of preoperative detection for apex prostate cancer by transrectal biopsy2013
Author(s)
Sazuka T, Imamoto T, Namekawa T, Utsumi T, Yanagisawa M, Kawamura K, Kamiya N, Suzuki H, Ueda T, Ota S, Nakatani Y, Ichikawa T:
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Journal Title
Prostate Cancer
Volume: -
Pages: 1-6
DOI
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Peer Reviewed
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[Journal Article] Clinical outcomes by relative docetaxel dose and dose intensity as chemotherapy for Japanese patients with castration- resistant prostate cancer: a retrospective multi-institutional collaborative study2013
Author(s)
Kamiya N, Suzuki H, Ueda T, Sato N, Nakatsu H, Mikami K, Sato N, Nomura K, Akakura K, Okano T, Ooki T, Naya Y, Ota S, Masai M, Ichikawa T
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Journal Title
Int J Clin Oncol
Volume: 7
Issue: 8
Pages: e42456-e42456
DOI
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Peer Reviewed
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[Journal Article] FOXA1 Promotes Tumor Progression in Prostate Cancer via the Insulin-Like Growth Factor Binding Protein 3 Pathway2012
Author(s)
Imamura Y, Sakamoto S, Endo T, Utsumi T, Fuse M, Suyama T, Kawamura K, Imamoto T, Yano K, Uzawa K, Nihei N, Suzuki H, Mizokami A, Ueda T, Seki N, Tanzawa H, Ichikawa T
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[Journal Article] Active surveillance criteria for prostate cancer: Can they be applied to Japanese patients ?2012
Author(s)
Goto Y, Nozumi K, Miyazaki K, Matsumoto A, Inoue A, Kito H, Hasegawa N, Nagata M, Kakuta Y, Suzuki H, Yamaguchi K
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Journal Title
Int J Urol
Volume: 19
Issue: 2
Pages: 163-166
DOI
NAID
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Peer Reviewed
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[Journal Article] 生検と全摘標本との間の,前立腺癌Gleason sum upgradingに関する検討2011
Author(s)
今本敬, 内海孝信, 高野慎, 柳沢充, 巣山貴仁, 川村幸治, 神谷直人, 二瓶直樹, 鈴木啓悦, ほか
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Journal Title
腎泌予防医誌
Volume: 19
Pages: 99-101
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[Journal Article] Komiya A, Shimbo M, Suzuki H, Imamoto T, Kato T, Fukasawa S, Kamiya N, Naya Y, Mori I, Ichikawa T2010
Author(s)
Komiya A, Shimbo M, Suzuki H, Imamoto T, Kato T, Fukasawa S, Kamiya N, Naya Y, Mori I, Ichikawa T
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Journal Title
Oncology Letters 1
Volume: 1
Issue: 1
Pages: 73-79
DOI
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Peer Reviewed
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[Journal Article] RIG-I Helicase-Independent Pathway in Sendai Virus-Activated Dendritic Cells Is Critical for Preventing Lung Metastasis of AT6.3 Prostate Cancer2010
Author(s)
Kato T, Ueda Y, Kinoh H, Yoneyama Y, Matsunaga A, Komaru A, Harada Y, Suzuki H, Komiya A, Shibata S, Hasegawa M, Hayashi H, Ichikawa T, Yonemitsu Y
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Journal Title
Neoplasia
Volume: 12
Pages: 906-914
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Peer Reviewed
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[Journal Article] Hormonal therapy for prostate cancer: current topics and future perspectives2010
Author(s)
Suzuki H, Hinotsu S, Akaza H, Fujii Y, Kawakami S, Kihara K, Akakura K, Suzuki M, Kitamura T, Homma Y, Mizokami A
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Journal Title
Int J Urol
Volume: 17(4)
Issue: 4
Pages: 302-313
DOI
NAID
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Peer Reviewed
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[Journal Article] Development and external validation of a nomogram predicting the probability of significant Gleason sum upgrading among Japanese patients with localized prostate cancer
Author(s)
Imamoto T, Utsumi T, Takano M, Komaru A, Fukasawa S, Suyama T, Kawamura K, Kamiya N, Miura J, Suzuki H, et al
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Journal Title
Prostate Cancer
Volume: (印刷中)
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Peer Reviewed
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[Presentation] シンポジウム「前立腺癌:ノモグラムとリスク分類の応用について」日本人データに基づいたリスク分類とノモグラム:J-CAPRA score と CHIBA nomogram2011
Author(s)
鈴木啓悦,岡了,杉浦恵子,遠藤匠,高野慎,矢野仁,直井牧人,西見大輔,神谷直人,内海孝信,川村幸治,今本敬,市川智彦
Organizer
第76回日本泌尿器科学会東部総会
Place of Presentation
横浜
Year and Date
2011-10-21
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[Presentation] パネルディスカッション「骨転移の治療」未治療前立腺癌骨転移症例に対するゾレドロン酸の有用性2010
Author(s)
神谷直人,鈴木啓悦,遠藤匠,高野慎,矢野仁,直井牧人,西見大輔,高波眞佐治,川村幸治,今本敬,市川智彦
Organizer
第48回日本癌治療学会総会
Place of Presentation
京都
Year and Date
2010-10-30
Related Report
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