Role of extracellular environment on development and organogenesisin prostate and bladder
| Project/Area Number |
22591764
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Yoshihiro 三重大学, 医学部附属病院, 助教 (10402687)
ISHII Kenichiro 三重大学, 大学院・医学系研究科, 助教 (90397513)
木瀬 英明 三重大学, 医学部附属病院, 講師 (80293786)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞外マトリックス / 前立腺 / 膀胱 / テネイシンC / 泌尿生殖洞 / 二核細胞 / GeneChip解析 / 遺伝子欠損マウス / 胎児泌尿生殖洞 / チモシンβ10 / 形態形成 / 間質-上皮の相互作用 / 組織組み替え実験 |
|---|
| Research Abstract |
Morphogenesis in tissue development depends on the relationships among cells, the extracellular matrix (ECM), and other support structures. Tenascin-C (TN-C) is a hexametric glycoprotein of the ECM produced mainly by stromal cells. In this study, we evaluated the gene expression profiles in TN-C knockout (TN-C KO) mouse urogenital sinus mesenchyme (mUGM). In TN-C KO mUGM, the expressions of thymosinβ10 and specific genes related to chemotaxis, cell-matrix adhesion, response to wounding, and collagen fibril organization were decreased or disappeared as compared to those in WT mUGM, suggesting that stromal TN-C signals and/or related signals might play an important role in development and organogenesis of prostate.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Naftopidil, a subtype selective alpha1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma2011
Author(s)
Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
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Journal Title
Cancer Prevention Research
Volume: 4
Pages: 87-96
Related Report
Peer Reviewed
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[Journal Article] Naftopidil, a selective alpha1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma2011
Author(s)
Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
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Journal Title
Cancer Prevention Research
Volume: 4
Pages: 87-96
Related Report
Peer Reviewed
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[Journal Article] Naftopidil, a subtype selective alpha 1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma2011
Author(s)
Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y.
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Journal Title
Cancer Prevention Research
Volume: 4
Pages: 87-96
Related Report
Peer Reviewed
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[Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer
Author(s)
Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer
Author(s)
Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y
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Journal Title
Urologic Oncology
Volume: (in press)
Related Report
Peer Reviewed
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[Presentation] Biological effects of fetal exposure to bisphenol A on urogenital sinus2010
Author(s)
Ishii K, Arase S, Yoshio Y, IgarashiK, Aisaki K, Hori Y, Nishikawa K, SogaN, Kise H, Arima K, Kanno J, SugimuraY
Organizer
The 2010 American Urological Association (AUA) Annual Meeting
Place of Presentation
San Francisco
Year and Date
2010-06-03
Related Report
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