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Role of extracellular environment on development and organogenesisin prostate and bladder

Research Project

Project/Area Number 22591764
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionMie University

Principal Investigator

SUGIMURA Yoshiki  三重大学, 大学院・医学系研究科, 教授 (90179151)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Yoshihiro  三重大学, 医学部附属病院, 助教 (10402687)
ISHII Kenichiro  三重大学, 大学院・医学系研究科, 助教 (90397513)
木瀬 英明  三重大学, 医学部附属病院, 講師 (80293786)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords細胞外マトリックス / 前立腺 / 膀胱 / テネイシンC / 泌尿生殖洞 / 二核細胞 / GeneChip解析 / 遺伝子欠損マウス / 胎児泌尿生殖洞 / チモシンβ10 / 形態形成 / 間質-上皮の相互作用 / 組織組み替え実験
Research Abstract

Morphogenesis in tissue development depends on the relationships among cells, the extracellular matrix (ECM), and other support structures. Tenascin-C (TN-C) is a hexametric glycoprotein of the ECM produced mainly by stromal cells. In this study, we evaluated the gene expression profiles in TN-C knockout (TN-C KO) mouse urogenital sinus mesenchyme (mUGM). In TN-C KO mUGM, the expressions of thymosinβ10 and specific genes related to chemotaxis, cell-matrix adhesion, response to wounding, and collagen fibril organization were decreased or disappeared as compared to those in WT mUGM, suggesting that stromal TN-C signals and/or related signals might play an important role in development and organogenesis of prostate.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (62 results)

All 2013 2012 2011 2010 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (39 results) Remarks (1 results)

  • [Journal Article] Low androgen sensitivity is associated with low levels of Akt phosphorylation in LNCaP-E9 cells2012

    • Author(s)
      Iguchi K, Fukami K, Ishii K, Otsuka T, Usui S, Sugimura Y, Hirano K
    • Journal Title

      Journal ofAndrology

      Volume: 33 Pages: 660-666

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the low pH/low nutrient-resistant LNCaP cell subline LNCaP-F102012

    • Author(s)
      Iguchi K, Hayakawa Y, Ishii K, Matsumoto K, Usui S, Sugimura Y, Hirano K
    • Journal Title

      Oncology Reports

      Volume: 28 Pages: 2009-2015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low androgen sensitivity is associated with low levels of Akt phosphorylation in LNCaP-E9 cells2012

    • Author(s)
      Iguchi K, Fukami K, Ishii K, Otsuka T, Usui S, Sugimura Y, Hirano K
    • Journal Title

      Journal of Andrology

      Volume: 33 Issue: 4 Pages: 660-666

    • DOI

      10.2164/jandrol.111.013888

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneous induction of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts by co-culturing with prostate cancer cells2011

    • Author(s)
      Ishii K, Mizokami A, Tsunoda T, Iguchi K, Kato M, Hori Y, Arima K, Namiki M, Sugimura Y
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 112 Pages: 3604-3611

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine disrupter bisphenol A increases in situ estrogen production in mouse urogenital sinus2011

    • Author(s)
      Arase S, Ishii K, Igarashi K, Aisaki K, Yoshio Y, Matsushima A, Shimohigashi Y, Arima K, Kanno J, Sugimura Y
    • Journal Title

      Biology of Reproduction

      Volume: 84 Pages: 734-742

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Naftopidil, a subtype selective alpha1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma2011

    • Author(s)
      Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
    • Journal Title

      Cancer Prevention Research

      Volume: 4 Pages: 87-96

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Androgen receptor W741C and T877A mutations in AIDL cells, an androgen independent subline of prostate cancer LNCaP cells2011

    • Author(s)
      Otsuka T, Iguchi K, Fukami K, Ishii K, Usui S, Sugimura Y, Hirano K
    • Journal Title

      Tumor Biology

      Volume: 32 Pages: 1097-1102

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural changes in alpha1-adrenoceptor antagonisttreated human prostatic stroma.2011

    • Author(s)
      Imamura T, Ishii K, Kanda H, Arase S, Yoshio Y, Hori Y, Soga N, Kise H, Arima K, Sugimura Y
    • Journal Title

      Clinical and Experimental Medicine

      Volume: 10 Pages: 99-106

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pedicled vastus lateralis musculofascial flap as a new technique for repairing rectourethral fistula after radical prostatectomy2011

    • Author(s)
      Iwamoto Y, Kanda H, Tsuji M, Toiyama Y, Yamada Y, Soga N, Arima K, Sudo A, Kusunoki M, Sugimura Y
    • Journal Title

      Microsurgery

      Volume: 31 Issue: 7 Pages: 564-567

    • DOI

      10.1002/micr.20923

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management of renal tumors in Von Hippel-Lindau disease by percutaneous CT fluoroscopic guided radiofrequency ablation : preliminary results2011

    • Author(s)
      Iwamoto Y, Kanda H, Yamakado K, Soga N, Arima K, Takeda K, Sugimura Y
    • Journal Title

      Familial Cancer

      Volume: 10 Pages: 529-534

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogenous induction of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts by co-culturing with prostate cancer cells2011

    • Author(s)
      Ishii K, Mizokami A, Tsunoda T, Iguchi K, Kato M, Hori Y, Arima K, Namiki M, Sugimura Y
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 112 Issue: 12 Pages: 3604-3611

    • DOI

      10.1002/jcb.23291

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naftopidil, a selective alpha1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma2011

    • Author(s)
      Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
    • Journal Title

      Cancer Prevention Research

      Volume: 4 Pages: 87-96

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine disruptor bisphenol A increases in situ estrogen production in the mouse urogenital sinus2011

    • Author(s)
      Arase S, Ishii K, Igarashi K, Aisaki K, Yoshio Y, Matsushima A, Shimohigashi Y Arima K, Kanno J, Sugimura Y
    • Journal Title

      Biology of Reproduction

      Volume: 84 Pages: 734-742

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial Bmp (Bone morphogenetic protein) signaling for bulbourethral gland development : a mouse model for congenital cystic dilation2011

    • Author(s)
      Omori A, Harada M, Ohta S, Villacorte M, Sugimura Y, Shiraishi T, Suzuki K, Nakagata N, Ito T, Yamada G
    • Journal Title

      Congenital Anomalies (Kyoto)

      Volume: 51 Issue: 3 Pages: 102-109

    • DOI

      10.1111/j.1741-4520.2011.00318.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Castration- and aging-induced changes in the expression of zinc transporter and metallothionein in rat prostate2011

    • Author(s)
      Iguchi K, Morihara N, Usui S, Hayama M, Sugimura Y, Hirano K
    • Journal Title

      Journal of Andrology

      Volume: 32 Pages: 144-150

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Naftopidil, a subtype selective alpha 1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma2011

    • Author(s)
      Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y.
    • Journal Title

      Cancer Prevention Research

      Volume: 4 Pages: 87-96

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interactions2010

    • Author(s)
      Tanaka ST, Ishii K, DeMarco RT, Pope JC 4th, Brock JW 3rd, Hayward SW
    • Journal Title

      Journal of Urology

      Volume: 183 Pages: 386-391

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of transforming growth factor α overexpression on urogenital organ development in mouse. Differentiation2010

    • Author(s)
      Yoshio Y, IshiiK, Arase S, Hori Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y
    • Journal Title

      Differentiation

      Volume: 80 Pages: 82-88

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of transforming growth factor α overexpression on urogenital organ development in mouse2010

    • Author(s)
      Yoshio Y, Ishii K, Arase S, Hori Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y.
    • Journal Title

      Differentiation

      Volume: 80 Pages: 82-88

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer

    • Author(s)
      Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y
    • Journal Title

      Urologic Oncology

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Manserin as a novel histochemical neuroendocrine marker in prostate cancer

    • Author(s)
      Nishikawa K, Soga N, Ishii K, Kato M, Iwamoto Y, Hori Y, Etoh M, Ohkawara T, Yamada T, Uchida K, Kise H, Arima K, Narita M, Shiraishi T, Sugimura Y
    • Journal Title

      Urologic Oncology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocrine disrupter bisphenol A increases in situ estrogen production in mouse urogenital sinus

    • Author(s)
      Arase S, Ishii K, Igarashi K, Aisaki K, Yoshio Y, Matsushima A, Shimohigashi Y, Arima K, Kanno J, Sugimura Y.
    • Journal Title

      Biology of Reproduction

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] エストロゲンにより誘導される前立腺基底上皮細胞過増殖の分子機構2013

    • Author(s)
      加藤 学、石井 健一朗、佐々木 豪、岩本 陽一、堀 靖英、山田 泰司、有馬公伸、白石 泰三、杉村 芳樹
    • Organizer
      第22回 泌尿器科分子・細胞研究会
    • Place of Presentation
      高知市
    • Year and Date
      2013-03-09
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 前立腺疾患の発生・進展における間質リモデリングの役割2012

    • Author(s)
      石井 健一朗、加藤 学、白石 泰三、杉村 芳樹
    • Organizer
      第28回 前立腺シンポジウム
    • Place of Presentation
      品川
    • Year and Date
      2012-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] A potential role of stromal interleukin-6 as paracrine-acting angiogenic cytokine in prostate cancer microenvironment2012

    • Author(s)
      Ishii K, Kato M, Iwamoto Y, Sasaki T, Iguchi K, Mizokami A, Arima K,Shiraishi T, Sugimura Y
    • Organizer
      25thAnnual Fall Meeting of the Society for Basic Urologic Research (SBUR)
    • Place of Presentation
      Florida
    • Year and Date
      2012-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] A potential role of TGF alpha in estrogenically induced squamous metaplasia in mouse prostate2012

    • Author(s)
      Kato M, Ishii K, Sasaki T, Iwamoto Y, Hori Y, Yamada Y, Arima K, ShiraishiT, Sugimura Y
    • Organizer
      25thAnnual Fall Meeting of the Society for Basic Urologic Research (SBUR)
    • Place of Presentation
      Florida
    • Year and Date
      2012-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌関連線維芽細胞由来インターロイキン-6による前立腺癌-間質のパラクライン・ループ活性化機構2012

    • Author(s)
      加藤 学、石井 健一朗、井口 和弘、溝上 敦、堀 靖英、山田 泰司、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      日本癌学会総会学術総会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] TGFα-EGF 受容体シグナルを介したエストロゲンによる前立腺基底上皮細胞の異常増殖と扁平上皮化生の誘導機構2012

    • Author(s)
      加藤 学、石井 健一朗、岩本 陽一、堀靖英、山田 泰司、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      第31回 日本アンドロロジー学会学術大会
    • Place of Presentation
      神戸市
    • Year and Date
      2012-06-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Aberrant activation of paracrine loop between prostate cancer cells and carcinoma-associated fibroblasts by overexpression of stromal interleukin-62012

    • Author(s)
      Ishii K, Iwamoto Y, Kato M, Iguchi K, Mizokami A, Arima K, Shiraishi T, Sugimura Y
    • Organizer
      The 2012 American Urological Association (AUA) Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2012-05-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Up-regulation of fibroblast growth factor 2 in castration-induced mouse prostate stromal remodeling lead to imbalance of basal epithelial-stromal interactions2012

    • Author(s)
      Kato M, Ishii K, Iwamoto Y, Hori Y, Yamada Y, Arima K, Shiraishi T, Sugimura Y
    • Organizer
      The 2012 American Urological Association (AUA) Annual Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2012-05-23
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト前立腺癌移植モデルにおけるα1アドレナリン受容体遮断薬が放射線感受性に与える影響2012

    • Author(s)
      岩本 陽一、神田 英輝、石井 健一朗、加藤 学、堀 靖英、山田 泰司、有 馬 公伸、杉村 芳樹
    • Organizer
      第100回 日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺癌-間質相互作用:去勢後の前立腺間質のリモデリングと増殖因子の解析2012

    • Author(s)
      加藤 学、石井 健一朗、岩本 陽一、堀 靖英、神田 英輝、山田 泰司、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      第100回 日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 癌間質由来インターロイキン-6 による前立腺癌-間質のパラクライン・ループ活性化機構2012

    • Author(s)
      石井 健一朗、岩本 陽一、加藤 学、井口 和弘、溝上 敦、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      第21回 泌尿器科分子・細胞研究会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 去勢後の前立腺間質リモデリングによるFGF2発現上昇が基底上皮-間質相互作用に及ぼす影響2012

    • Author(s)
      加藤 学、石井 健一朗、岩本 陽一、堀靖英、山田 泰司、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      第21回 泌尿器科分子・細胞研究会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト前立腺癌移植モデルにおけるα1アドレナリン受容体遮断薬が放射線感受性に与える影響2012

    • Author(s)
      岩本 陽一、神田 英輝、石井 健一朗、加藤 学 、堀 靖英、山田 泰司、有馬 公伸、杉村 芳樹
    • Organizer
      第21回 泌尿器科分子・細胞研究会
    • Place of Presentation
      札幌市
    • Year and Date
      2012-02-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺癌―間質相互作用:去勢後の前立腺間質のリモデリングと増殖因子の解析2012

    • Author(s)
      加藤 学、石井 健一朗、岩本 陽一、堀 靖英、神田 英輝、山田 泰司、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      第100回 日本泌尿器科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Up-regulation of fibroblast growth factor 2 in castration-induced mouse prostate stromal remodeling lead to imbalance of basal epithelial-stromal interactions2012

    • Author(s)
      Manabu Kato, Kenichiro Ishii, Yoichi Iwamoto, Yasuhide Hori, Yasushi Yamada, Kiminobu Arima, Taizo Shiraishi, Yoshiki Sugimura
    • Organizer
      The 2012 American Urological Association (AUA) Annual Meeting
    • Place of Presentation
      米国アトランタ
    • Related Report
      2012 Annual Research Report
  • [Presentation] TGFα-EGF受容体シグナルを介したエストロゲンによる前立腺基底上皮細胞の異常増殖と扁平上皮化生の誘導機構2012

    • Author(s)
      加藤 学、石井 健一朗、岩本 陽一、堀 靖英、山田 泰司、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      第31回 日本アンドロロジー学会学術大会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] A potential role of TGF alpha in estrogenically induced squamous metaplasia in mouse prostate2012

    • Author(s)
      Manabu Kato, Kenichiro Ishii, Takeshi Sasaki, Yoichi Iwamoto, Yasuhide Hori, Yasushi Yamada, Kiminobu Arima, Taizo Shiraishi, Yoshiki Sugimura
    • Organizer
      25th Annual Fall Meeting of the Society for Basic Urologic Research (SBUR)
    • Place of Presentation
      米国フロリダ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 前立腺癌-間質相互作用を標的にした新規治療戦略2011

    • Author(s)
      石井 健一朗、堀 靖英、杉村 芳樹
    • Organizer
      第70回 日本癌学会総会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Heterogeneous induction of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts by co-culturing with prostate cancer cells2011

    • Author(s)
      Ishii K, Mizokami A, Tsunoda T, IguchiK, Kato M, Hori Y, Arima K, Namiki M, Sugimura Y
    • Organizer
      9thWorld Congress on Urological Research
    • Place of Presentation
      Austria, Innsbruck
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanisms of prostatic structure maintenance by actions of androgen2011

    • Author(s)
      Kato M, Ishii K, Iwamoto Y, Hori Y, Yamada Y, Arima K, Shiraishi T, Sugimura Y
    • Organizer
      9thWorld Congress on Urological Research
    • Place of Presentation
      Austria, Innsbruck
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 動物モデルと前立腺増殖機構2011

    • Author(s)
      石井 健一朗、加藤 学、杉村 芳樹
    • Organizer
      第30回 日本アンドロロジー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] アンドロゲン依存的な前立腺組織構築の維持機構2011

    • Author(s)
      加藤 学、石井 健一朗、岩本 陽一、堀靖英、山田 泰司、曽我 倫久人、有馬 公伸、白石 泰三、杉村 芳樹
    • Organizer
      第30回 日本アンドロロジー学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺癌細胞株LNCaP細胞の亜株のアンドロゲン応答性変化機序2011

    • Author(s)
      大塚 崇史、井口 和弘、深見 和宏、石井 健一朗、臼井 茂之、杉村 芳樹、平野 和行
    • Organizer
      第57回 日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-07-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト前立腺癌細胞および間質細胞に対するフェニルピペラジン誘導体の細胞周期阻害作用2011

    • Author(s)
      石井 健一朗、堀 靖英、岩本 陽一、西川 晃平、加藤 学、神田 英輝、有馬 公伸、杉村 芳樹
    • Organizer
      第99回 日本泌尿器科学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺癌組織における新規神経内分泌物質Manserin発現の検討2011

    • Author(s)
      西川 晃平、曽我 倫久人、岩本 陽一、堀 靖英、石井 健一朗、木瀬 英明、有馬 公伸、杉村 芳樹
    • Organizer
      第99回 日本泌尿器科学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト前立腺癌間質モデルの作製と発生メカニズムの解析2011

    • Author(s)
      石井 健一朗、溝上 敦、西川 晃平、岩本 陽一、加藤 学、曽我 倫久人、木瀬英明、有馬 公伸、並木 幹夫、杉村 芳樹
    • Organizer
      第20回 泌尿器科分子・細胞研究会
    • Place of Presentation
      津市
    • Year and Date
      2011-03-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺癌組織における新規神経内分泌物質Manserin発現の検討2011

    • Author(s)
      西川 晃平、曽我 倫久人、加藤 学、岩本 陽一、石井 健一朗、山田 泰司、有馬 公伸、杉村 芳樹
    • Organizer
      第20回 泌尿器科分子・細胞研究会
    • Place of Presentation
      津市
    • Year and Date
      2011-03-12
    • Related Report
      2012 Final Research Report
  • [Presentation] アンドロゲン依存的な前立腺組織構築の維持機構2011

    • Author(s)
      加藤学、石井健一朗、岩本陽一、堀靖英、山田泰司、曽我倫久人、有馬公伸、白石泰三、杉村芳樹
    • Organizer
      第30回日本アンドロロジー学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms of prostatic structural maintenance by actions of androgen2011

    • Author(s)
      Kato M, Ishii K, Iwamoto Y, Hori Y, Yamada Y, Soga N, Arima K, Shiraishi T, Sugimura Y
    • Organizer
      9^<th> World Congress on Urological Research
    • Place of Presentation
      Austria, Innsbruck
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胎生期ビスフェノールA曝露による前立腺の異常増殖機構2010

    • Author(s)
      石井 健一朗、荒瀬 栄樹、吉尾 裕子、杉村 芳樹
    • Organizer
      第26回 前立腺シンポジウム
    • Place of Presentation
      品川
    • Year and Date
      2010-12-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Heterogeneity of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts2010

    • Author(s)
      石井 健一朗、堀 靖英、溝上 敦、山田 泰司、有馬 公伸、並木 幹夫、杉村 芳樹
    • Organizer
      第69回 日本癌学会総会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Phenylpiperazine derivatives induce G1 cell cycle arrest in human prostate cancer cells and stromal cells2010

    • Author(s)
      堀 靖英、石井 健一朗、山田 泰司、有馬 公伸、杉村 芳樹
    • Organizer
      第69回 日本癌学会総会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Experimental approach targeting tumor-stromal interactions in prostate cancer microenvironment2010

    • Author(s)
      杉村 芳樹、石井 健一朗
    • Organizer
      第69回 日本癌学会総会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of androgen-low sensitive LNCaP subline, LNCaP-E9 cells2010

    • Author(s)
      Iguchi K, Fukami K, Ishii K, Usui S, Sugimura Y, Hirano K
    • Organizer
      38thCongress of the International Society of Oncology and Biomarkers
    • Place of Presentation
      Munchen
    • Year and Date
      2010-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Biological effects of fetal exposure to bisphenol A on urogenital sinus2010

    • Author(s)
      Ishii K, Arase S, Yoshio Y, IgarashiK, Aisaki K, Hori Y, Nishikawa K, SogaN, Kise H, Arima K, Kanno J, SugimuraY
    • Organizer
      The 2010 American Urological Association (AUA) Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2010-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Unique growth-inhibitory effects of subtype selective 1-adrenoceptor antagonists on human prostate cancer cells2010

    • Author(s)
      Hori Y, Ishii K, Kanda H, Nishikawa K, Yoshio Y, Soga N, Kise H, Arima K, Sugimura Y
    • Organizer
      The 2010 American Urological Association (AUA) Annual Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2010-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 前立腺基底上皮細胞の生物学的特性:増殖因子と性ホルモンの影響2010

    • Author(s)
      吉尾 裕子、石井 健一朗、堀 靖英、西川 晃平、曽我 倫久人、木瀬 英明、有馬 公伸、杉村 芳樹
    • Organizer
      第98回 日本泌尿器科学会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-04-30
    • Related Report
      2012 Final Research Report
  • [Presentation] α1a アドレナリン受容体選択性遮断薬Silodosinによる癌微小環境を標的とした前立腺癌増殖抑制メカニズム2010

    • Author(s)
      堀 靖英、石井 健一朗、神田 英輝、西川 晃平、吉尾 裕子、曽我 倫久人、木瀬 英明、有馬 公伸、杉村 芳樹
    • Organizer
      第98回 日本泌尿器科学会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-04-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Experimental approach targeting tumor-stromal interactions in prostate cancer microenvironment2010

    • Author(s)
      杉村芳樹、右井健一朗
    • Organizer
      第69回 日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Remarks] 三重大学大学院医学系研究科 腎泌尿器外科学

    • URL

      http://www.medic.mie-u.ac.jp/urology/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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