| Project/Area Number |
22591769
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
YOKOMIZO Akira 九州大学, 大学院・医学研究院, 准教授 (60346781)
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| Co-Investigator(Kenkyū-buntansha) |
KUROIWA Kentaro 九州大学, 大学院・医学研究院, 講師 (90403964)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIOTA Masaki 九州大学, 大学院・医学研究院, 助教 (20635445)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 前立腺癌 / アンドロゲン受容体 / 酸化ストレス / 去勢抵抗性 / 去勢治療 / アンドログン受容体 |
|---|
| Research Abstract |
The functional analysis of androgen receptor (AR) in prostate cancer is most important to clarify mechanisms of developing castration-resistant prostate cancer (CRPC). Weidentified that oxidative stress and reactive oxygen species had played an important role in the progression to CRPC. And the transcription factors, Twist-1 and YB-1, are induced by this oxidative stress and had significant function to regulate AR in developing to CRPC. In addition, we obtained the novel molecular mechanisms on AR co-activators. Furthermore, we found the novel pharmacological function of aspirin and statin on AR regulations.
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