Investigation on clinicopathological significance of FES in prostate cancer

• Project/Area Number: 22591771
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagasaki University
• Principal Investigator: MIAYTA Yasuyoshi 長崎大学, 大学病院, 講師 (60380888)
• Co-Investigator(Kenkyū-buntansha): SAKAI Hideki 長崎大学, 医歯薬学総合研究科, 教授 (40235122)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: c-Fes / 前立腺癌 / 泌尿器癌 / 血管新生 / 腫瘍マーカー / Fes / cortactin / mast cell / Fer / FES / 分子標的治療 / 予後予測因子 / マウスモデル / 予後

Research Abstract

Expression of c-Fes was associated with malignant potential in KIMAP and human tissues of prostate cancer. In addition, we also found interestingfindings of various c-Fes-related-factors and -pathological phenomenon in comprehensive studies by using cell lines and tissues.

Research Products

• [Journal Article] Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome by angiogenesis and lymphangiogenesis (2013)
  • Author(s): Miyata Y, Ohba K, Matsuo T, Watanabe S, Hayashi T, Sakai H, et al
  • Journal Title: Urology Volume: 81 Pages: 136-42
  • Peer Reviewed
• [Journal Article] Feline sarcoma-related protein expression correlates with maligant aggressiveness and poor prognosis in renal cell carcinoma. (2013)
  • Author(s): Miyata Yasuyoshi
  • Journal Title: Cancer Science Volume: in press Issue: 6 Pages: 681-686
  • DOI: 10.1111/cas.12140
  • Peer Reviewed
• [Journal Article] Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome by angiogenesis and lymphangiogenesis. (2013)
  • Author(s): Miyata Yasuyoshi
  • Journal Title: Urology Volume: 81 Issue: 1 Pages: 136-142
  • DOI: 10.1016/j.urology.2012.08.014
  • Peer Reviewed
• [Journal Article] 泌尿器系癌におけるEプロスタノイドレセプターとその役割 (2013)
  • Author(s): 大庭 康司郎
  • Journal Title: 泌尿器科紀要 Volume: 59 Pages: 83-89
  • Peer Reviewed
• [Journal Article] Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer (2012)
  • Author(s): Miyata Y, Watanabe S, Matsuo T, Hayashi T, Sakai H, et al.
  • Journal Title: Prostate Volume: 72 Pages: 201-8
  • Peer Reviewed
• [Journal Article] High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2 (2012)
  • Author(s): Watanabe S, Miyata Y, Matsuo T, Mochizuki Y, Nishikido M, Hayashi T, Sakai H
  • Journal Title: Hum Pathol Volume: 43 Pages: 888-97
  • Peer Reviewed
• [Journal Article] High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2. (2012)
  • Author(s): Watanabe Shinichi
  • Journal Title: Human Pathology Volume: 43 Issue: 6 Pages: 888-897
  • DOI: 10.1016/j.humpath.2011.07.019
  • Peer Reviewed
• [Journal Article] Pathologic significance and prognostic value of phosphorylated cortactin expression in patients with sarcomatoid renal cell carcinoma. (2012)
  • Author(s): Matsuo Tomohiro
  • Journal Title: Urology Volume: 78 Issue: 2 Pages: 476.e9-476.e15
  • DOI: 10.1016/j.urology.2011.03.019
  • Peer Reviewed
• [Journal Article] Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer (2012)
  • Author(s): Miyata Y, Watanabe S, Matsuo T, Hayashi T, Sakai H, Xuan JW, Greer PA, Kanda S
  • Journal Title: Prostate Volume: 72 Issue: 2 Pages: 201-208
  • DOI: 10.1002/pros.21422
  • Peer Reviewed
• [Journal Article] The c-Fes protein tyrosine kinase as a potential anti-angiogenic target in cancer. (2011)
  • Author(s): Kanda S, Miyata Y
  • Journal Title: Front Biosci Volume: 16 Pages: 1024-35
  • NAID: 120006984878
  • Peer Reviewed
• [Journal Article] Pathologic significance and prognostic value of phosphorylated cortactin expression in patients with sarcomatoid renal cell carcinoma (2011)
  • Author(s): Mat s u o T, Miyata Y, Watanabe S, Ohba K, Hayashi T, Kanda S, Sakai H
  • Journal Title: Urology Volume: 78
  • Peer Reviewed
• [Journal Article] Clinical significance and predictive value of prostaglandin E2 receptors (EPR) 1 - 4 in patients with renal cell carcinoma (2011)
  • Author(s): Ohba K, Miyata Y, Watanabe S, Hayashi T, Kanetake H, Kanda S, Sakai H
  • Journal Title: Anticancer Res Volume: 31 Pages: 597-605
  • Peer Reviewed
• [Journal Article] 前立腺癌におけるc-Fes発現と臨床病理学的特徴や増殖,アポトーシスとの関連 (2011)
  • Author(s): 宮田康好、渡邉慎一、松尾朋博、相良祐次、大庭康司郎、酒井英樹、神田 滋
  • Journal Title: 泌尿器外科 Volume: 24 Pages: 1245-1248
  • Peer Reviewed
• [Journal Article] Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer (2011)
  • Author(s): Myata Y, Shin-ichi Watanabe, Tomohiro Matsuo, et al.
  • Journal Title: The Prostate Volume: (In press 掲載確定)
  • Peer Reviewed
• [Journal Article] Feline sarcoma-related protein expression correlates with malignant aggressiveness and poor prognosis in renal cell carcinoma
  • Author(s): Miyata Y, Kanda S, Sakai H, et al.
  • Journal Title: Cancer Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] 泌尿器癌におけるEプロスタノイドレセプターとその役割
  • Author(s): 大庭康司、宮田康好、酒井英樹
  • Journal Title: 泌尿紀要 Volume: (in press)
  • Peer Reviewed
• [Presentation] Cigarette smoking induces lymphangiogenesis, but not angiogenesis, and vascular endothelial growth factor-D, but not -A or -C in human bladder cancer tissues (2013)
  • Author(s): Miyata Y, Mitsunari K, Matsuo T, Ohba K, Hideki Sakai
  • Organizer: 08th. American urological Association Annual Meeting
  • Place of Presentation: San Diego, CA
• [Presentation] 低グルコース環境における腎癌細胞の動態についての検討 (2013)
  • Author(s): 宮田 康好
  • Organizer: 第２１回泌尿器科分子・細胞研究会
  • Place of Presentation: 高知市
• [Presentation] 低グルコース環境における腎癌細胞の動態についての検討 (2012)
  • Author(s): 宮田康好、酒井英樹、他
  • Organizer: 第21回泌尿器分子・細胞研究会
• [Presentation] Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome via angiogenesis and lymphangiogenesis (2012)
  • Author(s): 松尾朋博、宮田康好、酒井英樹、他
  • Organizer: 第64回日本泌尿器科学会西日本総会
• [Presentation] Semi-quantification of angiogenesis in urothelial cancer of upper urinary tract: a comparison among three endothelial markers (2012)
  • Author(s): Miyata Y, Matsuo T, Ohba K, Sakai H
  • Organizer: 107th. American urological Association Annual Meeting
• [Presentation] Tumor-associated stromal cells expressed EP2 receptor and EP3 receptor correlate with malignant aggressiveness and outcome through angiogenesis and lymphangiogenesis in prostate cancer (2012)
  • Author(s): Miyata Y, Ohba K, Matsuo T, Sakai H
  • Organizer: 27thAnnual EAU Congress
  • Place of Presentation: Paris, France
• [Presentation] Relationships between 4N1K-containing protein and clinicopathological features, prognosis, and angiogenesis in urothelial cancer of upper urinary tract (2012)
  • Author(s): Miyata Y, Matsuo T, Ohba K, Sakai H
  • Organizer: 27thAnnual EAU Congress
  • Place of Presentation: Paris, France
• [Presentation] Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome via angiogenesis and lymphangiogenesis. (2012)
  • Author(s): 松尾朋博
  • Organizer: 第６４回日本泌尿器科学会西日本総会
  • Place of Presentation: 徳島市
• [Presentation] athological significance and prognostic value of phosphorylated cortactin expression in patients with sarcomatoid renal cell carcinoma (2011)
  • Author(s): Mat s u o T, Miyata Y, Watanabe S, Ohba K, Hayashi T, Kanda S, Sakai H
  • Organizer: 第63回日本泌尿器科学会西日本総会
• [Presentation] Clinical significance and predictive value of prostaglandin E2 receptors (EPR) 1-4 in patients with renal cell carcinoma (2011)
  • Author(s): Ohba K, Miyata Y, Watanabe S, Hayashi T, Kanetake H, Kanda S, and Sakai H
  • Organizer: 第63回日本泌尿器科学会西日本総会
• [Presentation] Fpsの発現抑制は膀胱癌発癌に関与し、非浸潤性膀胱癌の悪性度の増強や尿路再発と関連す る (2011)
  • Author(s): 宮田康好,神田 滋,酒井英樹
  • Organizer: 第69回日本癌学会学術総会
• [Presentation] Greer: Pathological roles and predictive value for recurrence into urothelial tract of Fps expression in patients with bladder cancer (2011)
  • Author(s): Miyata Y, Kanda S, Sakai H, and Peter A
  • Organizer: 106th. American Urological AssociationAnnual Meeting
  • Place of Presentation: Washington DC
• [Presentation] Fer is proliferative regulator of renal cancer cells and its expression was associated with pathological features and survival in patients with renal cell carcinoma (2011)
  • Author(s): Miyata Y, Kanda S, Sakai H, Peter A. Greer
  • Organizer: American Urological Association, Annual Meeting
  • Place of Presentation: Washington DC
• [Presentation] 前立腺癌組織におけるcortactin発現についての検討 (2011)
  • Author(s): 渡邉慎一,宮田康好,松尾朋博,井川 掌,酒井英樹
  • Organizer: 99回日本泌尿器科学会総会
• [Presentation] 腎癌組織におけるprostaglandin E2 receptor (EPR) 1～4の臨床的意義と予後との関連についての検討 (2011)
  • Author(s): 大庭康司郎,宮田康好,相 良 祐 次 ,林 徳真吉,金武 洋,神田 滋,酒井英樹
  • Organizer: 第99回日本泌尿器科学会総会
• [Presentation] Fpsは膀胱癌の発癌に関与し、その発現は臨床病理学的特徴や尿路再発に関連している (2011)
  • Author(s): 宮田康好,神田 滋,酒井英樹,Peter A. Greer
  • Organizer: 第99回日本泌尿器科学会総会
• [Presentation] 肉腫様膀胱癌におけるリン酸化cortactin の臨床病理学的意義についての検討 (2011)
  • Author(s): 相良祐次,宮田康好,松尾朋博,渡邉慎一,大庭康司郎,望月保志,錦戸雅春,酒井英樹
  • Organizer: 第99回日本泌尿器科学会総会
• [Presentation] 腎癌細胞におけるFerの臨床病理学的役割 (2011)
  • Author(s): 宮田康好,神田 滋,Peter A. Greer,酒井英樹
  • Organizer: 第20回泌尿器科分子・細胞研究会
• [Presentation] 前立腺癌におけるc-Fes発現と臨床病理学的特徴や増殖、アポトーシスとの関連 (2010)
  • Author(s): 宮田康好,渡邉慎一,松尾朋博,林 徳真吉,J im W. Xuan,Peter A. Greer,神 田 滋,金武 洋,酒井英樹
  • Organizer: 第26回前立腺シンポジウム
• [Book] BLADDER CANCER FROM BASIC SCIENCE TO ROBOTIC SURGERY. Chapter 5, Angiogenesis and Lymphangiogenesis in Bladder Cancer. Edited by Abdullah E Canda (2012)
  • Author(s): Miyata Y, Sakai H, and Kanda S
  • Publisher: INTECH WEB. ORG., Croatia
• [Book] BLAADER CANCER FROM BASIC SCIENCE TO ROBOTIC SURGERY (2012)
  • Author(s): Yasuyoshi Miyata
  • Total Pages: 460
  • Publisher: InTech
• [Book] Atlas of Genetics and Cytogenesis in Oncology and Hematology ETV4 (ets variant 4) (2011)
  • Author(s): Miyata Y