Analysis of the regulation of androgen receptor by renin-angiotensin system in prostate cancer

• Project/Area Number: 22591774
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Yokohama City University
• Principal Investigator: UEMURA Hiroji 横浜市立大学, 附属病院, 准教授 (50244439)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Yoshinobu 横浜市立大学, 医学研究科, 教授 (10106312)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 前立腺癌 / アンドロゲンレセプター / レニン-アンジオテンシン系 / 化学予防

Research Abstract

We have confirmed that renin-angiotensin system have the potential to Regulate the expression of androgen receptor in prostate cancer cells via in vitro and in vivo experiment. Furthermore, we conducted a clinical study to confirm whether angiotensin II receptor blocker (ARB) would influence the development of prostate cancer .As a result, ARB has the potential to inhibit the expression of androgen receptor through AT1 receptor. Furthermore, clinical study revealed that ARB treatment delayed PSA risingin patients with PSA recurrence after prostatectomy.

Research Products

• [Journal Article] Thearpeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer (2012)
  • Author(s): S Takahashi, H Uemura, A Seeni, M Tang, M Komiya, N Long, H Ishiguro, Y Kubota and T Shirai
  • Journal Title: Prostate Volume: 72(14) Pages: 1559-72
  • Peer Reviewed
• [Journal Article] Identification of miR-30d as a novel prognostic maker of prostate cancer (2012)
  • Author(s): Kobayashi N, Uemura H, Nagahama K, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H.
  • Journal Title: Oncotarget Volume: 3(11) Pages: 1455-71
  • Peer Reviewed
• [Journal Article] Usefulness of Perflubutane Microbubble-Enhanced Ultrasound in Imaging and Detection of Prostate Cancer: Phase 2 Multicenter Clinical Trial. (2012)
  • Author(s): H Uemura, F Sano, A Nomiya, T Yamamoto, M Nakamura, Y Miyoshi, K Miki, K Noguchi, S Egawa, Y Homma and Y Kubota
  • Journal Title: World J Urol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Uemura to case 2 discussion: Castration-resistant prostate cancer (2012)
  • Author(s): H Uemura, Answer by Dr
  • Journal Title: Int J Urology Volume: 19 Pages: 379-381
• [Journal Article] Possible Anti-tumor Activity of Initial Treatment withZoledronic Acid with Hormonal Therapy for Bone-Metastatic Prostate Cancer in Multicenter Clinical Trial (2012)
  • Author(s): H Uemura, M Yanagisawa, I Ikeda, K Fujinami, A Iwasaki, S Noguchi, KNoguchi, Y Kubota
  • Journal Title: Int J Clin Oncol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Thearpeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer (2012)
  • Author(s): Satoru Takahashi
  • Journal Title: Prostate Volume: 72 Issue: 14 Pages: 1559-1572
  • DOI: 10.1002/pros.22505
  • Peer Reviewed
• [Journal Article] Identification of miR-30d as a novel prognostic maker of prostate cancer. (2012)
  • Author(s): Naohito Kobayashi
  • Journal Title: Oncotarget Volume: 3 Pages: 1455-71
  • Peer Reviewed
• [Journal Article] Usefulness of Perflubutane Microbubble-Enhanced Ultrasound in Imaging and Detection of Prostate Cancer: Phase 2 Multicenter Clinical Trial (2012)
  • Author(s): Hiroji Uemura
  • Journal Title: World Journal of Urology Volume: 31 Issue: 5 Pages: 1123-1128
  • DOI: 10.1007/s00345-012-0833-1
  • Peer Reviewed
• [Journal Article] The 7th American Urological Association and the Japanese Urological Association International Affiliate Society Meeting (2012)
  • Author(s): Yukio Homma
  • Journal Title: Int J Urology Volume: 19 Issue: 4 Pages: 374-385
  • DOI: 10.1111/j.1442-2042.2012.02984.x
  • Peer Reviewed
• [Journal Article] The co-expression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence (2012)
  • Author(s): Ishiguro H, et al
  • Journal Title: Cancer Science Volume: 102 Pages: 1576-1581
  • Peer Reviewed
• [Journal Article] The potential of FDG-PET/CT for detecting prostate cancer in patients with an elevated serum PSA level (2011)
  • Author(s): R Minamimoto, H Uemura, F Sano, H Terao, Y Nagashima, S Yamanaka, K Shizukuishi, U Tateishi, Y Kubota, T Inoue.
  • Journal Title: Ann Nucl Med Volume: 25 Pages: 21-27
  • NAID: 10028998804
  • Peer Reviewed
• [Journal Article] Engagement of renin-angiotensin system in prostate cancer (2011)
  • Author(s): H Uemura, K Hoshino, Y Kubota.
  • Journal Title: Curr Cancer Drug Targets Volume: 11(4) Pages: 442-450
  • Peer Reviewed
• [Journal Article] Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis (2011)
  • Author(s): K Endoh, M Nishi, H Ishiguro, H Uemura,Y Miyagi, I Aoki, H Hirano, Y Kubota, A Ryo.
  • Journal Title: Prostate Volume: 72(6) Pages: 626-637
  • Peer Reviewed
• [Journal Article] The co- -6 in prostate cancer tissue correlates with biochemical recurrence (2011)
  • Author(s): Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano JY, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, Uemura H.
  • Journal Title: Cancer Sci Volume: 102(8) Pages: 1576-1581
  • Peer Reviewed
• [Journal Article] Regulation of androgen receptor expression through angiotensin II type 1 receptor in prostate cancer cells (2011)
  • Author(s): K Hoshino, H Ishiguro, J Teranishi, S Yoshida, S Umemura, YKubota, H Uemura
  • Journal Title: Prostate Volume: 71 (9) Pages: 964-975
  • Peer Reviewed
• [Journal Article] Contrast-enhanced ultrasonography of the prostate: Various imaging findings that indicate prostate cancer (2011)
  • Author(s): F Sano, H Terao, T Kawahara, Y Miyoshi, T Sasaki, K Noguchi, Y Kubota, H Uemura
  • Journal Title: BJU Int Volume: 107(9) Pages: 1404-1410
  • Peer Reviewed
• [Journal Article] High-grade invasive urothelial carcinoma with focal plasmacytoid differentiation successfully treated by transurethral resection followed by chemoradiotherapy (2011)
  • Author(s): Kawahara T, Oshiro H, Sekiguchi Z, Ito H, Makiyama K, Uemura H, Kubota Y
  • Journal Title: Int J Urol Volume: 18(12) Pages: 851-3
  • NAID: 10031164891
  • Peer Reviewed
• [Journal Article] Engagement of renin-angiotensin system in prostate cancer (2011)
  • Author(s): H Uemura, et al
  • Journal Title: Current Cancer Drug Targets Volume: 11 Pages: 442-450
  • Peer Reviewed
• [Journal Article] Regulation of androgen receptor expression through angiotens in II type 1 receptor in prostate cancer cells (2011)
  • Author(s): K Hoshino, et al
  • Journal Title: Prostate Volume: 71 Pages: 964-975
  • Peer Reviewed
• [Journal Article] Regulation of androgen receptor expression through angiotens in II type 1 receptor in prostate cancer cells. (2011)
  • Author(s): K Hoshino, et al.
  • Journal Title: Prostate Volume: 71(印刷中)
  • Peer Reviewed
• [Journal Article] Engagement of renin-angiotensin system in prostate cancer (2011)
  • Author(s): H Uemura, et al.
  • Journal Title: Curr Cancer Drug Targets Volume: 11(印刷中)
  • Peer Reviewed
• [Journal Article] Analysis of NSAID-activated gene-1 (NAG-1) expression in prostatecancer (2010)
  • Author(s): T Kawahara, H Ishiguro, KHoshino, J Teranishi, Y Miyoshi, Y Kubota , H Uemura
  • Journal Title: Urol Int Volume: 84 Pages: 198-202
  • Peer Reviewed
• [Journal Article] 座談会「レニンーアンジオテンシン系(RAS)抑制と癌治療」 (2010)
  • Author(s): 木原和徳、上村博司, 他
  • Journal Title: 日本臨牀 Volume: 68 Pages: 1177-1185
  • NAID: 40017138840
• [Presentation] Possibility and Limitation of Androgen Receptor as a Molecular Target for Prostate Cancer (2013)
  • Author(s): H Uemura
  • Organizer: 19th International Charles Heidelberger Symposium on Cancer Research
  • Place of Presentation: 鹿児島大学(鹿児島)
  • Year and Date: 2013-02-16
• [Presentation] 前立腺癌薬物療法、今後の展開 (2013)
  • Author(s): 上村博司
  • Organizer: 前立腺癌 Expert Meeting Sat
  • Place of Presentation: ホテルニューオータニ(東京)
  • Year and Date: 2013-02-09
• [Presentation] 前立腺癌薬物治療の新戦略 (2012)
  • Author(s): 上村博司
  • Organizer: 第56回 TEUS(Tokyo Expert Urology Seminar)
  • Place of Presentation: 東京ドームホテル(東京)
  • Year and Date: 2012-12-03
• [Presentation] Possibility an limitation of androgen receptor as molecular target for prostate cancer (2012)
  • Author(s): H Uemura, Y Itoh, Y Kubota
  • Organizer: 15th International Congress on Hormone Steroids and Hormone & Cancer, Symposium 8, Prostate cancer, Invited
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2012-11-17
• [Presentation] 限局性前立腺癌に対する放射線治療について、イブニングセミナー、「限局性前立腺癌に対する治療選択」 (2012)
  • Author(s): 上村博司
  • Organizer: 第62回日本泌尿器科学会中部総会
  • Place of Presentation: 富山国際会議場(富山県)
  • Year and Date: 2012-11-02
• [Presentation] 去勢抵抗性前立腺癌の話題「去勢抵抗性前立腺癌-治療の現状と分子メカニズム」 (2012)
  • Author(s): 上村博司
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2012-10-27
• [Presentation] ハイリスク前立腺癌の治療戦略、症例検討パネルディスカッション (2012)
  • Author(s): 上村博司
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2012-10-25
• [Presentation] 前立腺癌の画像診断と PSA (2012)
  • Author(s): 上村博司
  • Organizer: 日本臨床検査自動化学会第44回大会、インテグレーションセミナー
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2012-10-13
• [Presentation] 我が国における去勢抵抗性前立腺癌の現状 (2012)
  • Author(s): 上村博司
  • Organizer: 第19回東京前立腺癌フォーラム、シンポジウム
  • Place of Presentation: 丸ビル(東京)
  • Year and Date: 2012-10-06
• [Presentation] Regulation of androgen receptor by angiotensin1-7 in prostate cancer cells (2012)
  • Author(s): 上村博司、伊藤悠亮、石黒斉、窪田吉信
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-21
• [Presentation] これから期待される前立腺癌内分泌治療薬 (2012)
  • Author(s): 上村博司
  • Organizer: 第9回日本臨床泌尿器科医会学術講演会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2012-07-18
• [Presentation] アンジオテンシンIIレセプターブロッカーの前立腺癌発生予防の実験的検証 (2012)
  • Author(s): 上村博司、伊藤悠亮、星野耕二、高橋智、窪田吉信
  • Organizer: 第21回日本腎泌尿器疾患予防医学研究会
  • Place of Presentation: 高知文化プラザ(高知県)
  • Year and Date: 2012-07-13
• [Presentation] 治療法から見た去勢抵抗性前立腺癌の進展とその対策 (2012)
  • Author(s): 上村博司
  • Organizer: 第25回日本老年泌尿器科学会イブニングセミナー
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2012-06-01
• [Presentation] Answer to case discussion2, Case discussion 2 "Castration-resistant prostate cancer-CRPC" (2012)
  • Author(s): H Uemura
  • Organizer: The 7thAUA/JUA International Affiliate Society Meeting
  • Place of Presentation: アトランタ、(米国)
  • Year and Date: 2012-05-20
• [Presentation] Usefulness of Contrast Enhanced Ultrasound in Imaging and Detection of Prostate Cancer, Symposium "Genitourinary" (2012)
  • Author(s): H Uemura
  • Organizer: The 4thAsian Conference on Ultrasound Contrast Imaging
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2012-05-13
• [Presentation] 去勢抵抗性前立腺癌に対するアンドロゲンレセプターの標的分子としての可能性と限界 (2012)
  • Author(s): 上村博司
  • Organizer: 第100回日本泌尿器科学会総会シンポジウム「前立腺癌の内分泌治療の新しい展開」
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2012-04-22
• [Presentation] Safety and efficacy of docetaxel in prostate cancer patients: based on th post-marketing suveillance in Japan (2012)
  • Author(s): H Uemura
  • Organizer: Asia-Pacific genitourinary conference
  • Place of Presentation: 台北(台湾)
• [Presentation] Safety and efficacy of docetaxel in prostate cancer patients: based on th post-marketing suveillance in Japan. (2012)
  • Author(s): Hiroji Uemura
  • Organizer: Asia-Pacific genitourinary conference
  • Place of Presentation: 台北市（台湾）
  • Invited
• [Presentation] 去勢抵抗性前立腺癌に対する新規ホルモン療法について (2011)
  • Author(s): 上村博司
  • Organizer: Urology Seminar
  • Place of Presentation: 帝国ホテル(東京)
  • Year and Date: 2011-11-25
• [Presentation] 前立腺癌の新たな治療の探索、教育講演 (2011)
  • Author(s): 上村博司
  • Organizer: 第76回日本泌尿器科学会東部総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-10-21
• [Presentation] 前立腺癌の新たな治療の探索 (2011)
  • Author(s): 上村博司
  • Organizer: 第76回日本泌尿器科学会東部総会
  • Place of Presentation: パシフィコ(横浜)
  • Year and Date: 2011-10-21
• [Presentation] 去勢抵抗性前立腺癌に対する治療戦略、最新の知見を含めて (2011)
  • Author(s): 上村博司
  • Organizer: 第10回奈良前立腺研究会
  • Place of Presentation: シェラトン都ホテル(大阪)
  • Year and Date: 2011-07-22
• [Presentation] ANGIOTENSIN II RECEPTOR BLOCKER HAS THE POTENTIAL TO SUPPRESS PSA FAILURE AFTER PROSTATECTOMY (2011)
  • Author(s): Hiroji Uemura, Narihiko Hayashi, Futoshi Sano, Hitoshi Ishiguro, Kouji Hoshino, Yasuhide Miyoshi, Jun-ichi Teranishi, Kazumi Noguchi, YoshinobuKubota
  • Organizer: アメリカ泌尿器科学会総会
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2011-05-16
• [Presentation] Angiotensin II receptor blocker has the potential to suppress PSA failure after prostatectomy (2011)
  • Author(s): H Uemura
  • Organizer: アメリカ泌尿器科学会総会
  • Place of Presentation: 米国ワシントンDC
  • Year and Date: 2011-05-16
• [Presentation] 去勢抵抗性前立腺癌の新しい標的分子と臨床への応用について、シンポジウム:前立腺癌研究の最新の進歩:基礎研究から臨床に向けて (2011)
  • Author(s): 上村博司
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-04-21
• [Presentation] 去勢抵抗性前立腺癌の新しい標的分子と臨床への応用について (2011)
  • Author(s): 上村博司
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 国際会議場(名古屋)
  • Year and Date: 2011-04-21
• [Presentation] リスク分類に基づいた早期癌の治療戦略、パネルディスカッション「早期前立腺癌の治療戦略」 (2010)
  • Author(s): 上村博司
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 国立京都国際会議場(京都)
  • Year and Date: 2010-10-30
• [Presentation] Role of Renin-Angiotensin System in Prostate Cancer, Symposium "Angiotensin" (2010)
  • Author(s): Hiroji Uemura, Satoru Takahashi, Kouji Hoshino, Hitoshi Ishiguro, Yoshinobu Kubota
  • Organizer: 14thInternational Congress on Hormone Steroids and Hormones & Cancer
  • Place of Presentation: エンジンバラ、英国
  • Year and Date: 2010-09-22
• [Presentation] Role of Renin-Angiotensin System in Prostate Cancer (2010)
  • Author(s): Hiroji Uemura
  • Organizer: 14^<th> International Congress on Hormone Steroids and Hormones&Cancer
  • Place of Presentation: 英国、エンジンバラ(招待講演)
  • Year and Date: 2010-09-22
• [Presentation] 前立腺癌におけるレニン-アンジオテンシン系の役割 (2010)
  • Author(s): 上村博司
  • Organizer: 第3回前立腺生物学シンポジウム伊勢志摩
  • Place of Presentation: 鳥羽国際ホテル(三重県)
  • Year and Date: 2010-06-18
• [Presentation] 前立腺癌におけるレニン-アンジオテンシン系の役割 (2010)
  • Author(s): 上村博司
  • Organizer: 第3回前立腺生物学シンポジウム伊勢志摩2010
  • Place of Presentation: 三重県、鳥羽市・鳥羽国際ホテル(招待講演)
  • Year and Date: 2010-06-18
• [Presentation] Possibility and Limitation of Androgen Receptor as a Molecular Target for Prostate Cancer
  • Author(s): Hiroji Uemura
  • Organizer: 19th International Charles Heidelberger Symposium on Cancer Research
  • Place of Presentation: 鹿児島大学（鹿児島県）
  • Invited
• [Presentation] Possibility an limitation of androgen receptor as molecular target for prostate cancer
  • Author(s): Hiroji Uemura
  • Organizer: 15th International Congress on Hormone Steroids and Hormone & Cancer
  • Place of Presentation: 石川県立音楽堂（石川県）
  • Invited
• [Presentation] 去勢抵抗性前立腺癌－治療の現状と分子メカニズム
  • Author(s): 上村博司
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Invited
• [Presentation] Usefulness of Contrast Enhanced Ultrasound in Imaging and Detection of Prostate Cancer
  • Author(s): Hiroji Uemura
  • Organizer: he 4th Asian Conference on Ultrasound Contrast Imaging
  • Place of Presentation: ソウル市（韓国 ）
  • Invited