Functional analysis of miRNAs in microenvironment of CRPC.

• Project/Area Number: 22591777
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Keio University
• Principal Investigator: MIYAJIMA Akira 慶應義塾大学, 医学部, 講師 (90245572)
• Co-Investigator(Kenkyū-buntansha): OYA Mototsugu 慶應義塾大学, 医学部, 教授 (00213885) ; KIKUCHI Eiji 慶應義塾大学, 医学部, 講師 (10286552)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 前立腺癌 / 微小環境 / 血管新生 / miRNA / 去勢抵抗性 / マイクロRNA

Research Abstract

Prostate cancer (PCa) is one of the most commonly diagnosed malignant tumors in men and the second leading cause of cancer-related deaths in the United States. One of the most troublesome aspects of PCa is that androgen-dependent PCa inevitably progresses

Research Products

• [Journal Article] The prognostic significance of vasohibin-1 expression in patients with prostate cancer. (2013)
  • Author(s): Kosaka T, Miyazaki Y, Miyajima A, Mikami S, Hayashi Y, Tanaka N, Nagata H, Kikuchi E, Nakagawa K, Okada Y, Sato Y, Oya M
  • Journal Title: Br J Cancer. Volume: 108 Issue: 10 Pages: 2123-2129
  • DOI: 10.1038/bjc.2013.169
  • Peer Reviewed
• [Journal Article] Human castrationresistant prostate cancer rather prefer to decreased 5α-reductase activity. (2013)
  • Author(s): Kosaka T, Miyajima A, Nagata H, Maeda T, Kikuchi E, Oya M.
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 1268-1268
  • DOI: 10.1038/srep01268
  • Peer Reviewed
• [Journal Article] Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1receptor in prostate cancer (2012)
  • Author(s): Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y, Oya M
  • Journal Title: Am J Pathol. Volume: 180(3) Issue: 3 Pages: 1008-16
  • DOI: 10.1016/j.ajpath.2011.11.027
  • Peer Reviewed
• [Journal Article] Low-dose docetaxel enhances the sensitivity of S-1 in a xenograft model of human castration resistant prostate cancer. (2012)
  • Author(s): Hasegawa M, Miyajima A, Kosaka T, Yasumizu Y, Tanaka N, Maeda T, Shirotake S, Ide H, Kikuchi E, Oya M
  • Journal Title: Int J Cancer. Volume: 130(2) Issue: 2 Pages: 431-42
  • DOI: 10.1002/ijc.26012
  • Peer Reviewed
• [Journal Article] Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer. (2012)
  • Author(s): Shirotake S
  • Journal Title: Am J Pathol Volume: 180 Issue: 9 Pages: 1199-1202
  • DOI: 10.1089/end.2011.0589
  • Peer Reviewed
• [Journal Article] Phosphorylated Akt up-regulates angiotensin II type-1 receptor expression in castration resistant prostate cancer. (2011)
  • Author(s): Kosaka T, Miyajima A, Shirotake S, Kikuchi E, Oya M
  • Journal Title: Prostate Volume: 71 Issue: 14 Pages: 1510-1517
  • DOI: 10.1002/pros.21367
  • Peer Reviewed
• [Journal Article] Long-term androgen ablation and docetaxel up-regulate phosphorylated Akt in castration resistant prostate cancer (2011)
  • Author(s): Kosaka T, Miyajima A, Shirotake S, Suzuki E, Kikuchi E, Oya M
  • Journal Title: J Urol Volume: 185(6) Issue: 6 Pages: 2376-81
  • DOI: 10.1016/j.juro.2011.02.016
  • Peer Reviewed
• [Journal Article] Acquired platinum resistance enhances tumour angiogenesis through angiotensin II type 1 receptor in bladder cancer (2011)
  • Author(s): Tanaka N, Miyajima A, 他6名
  • Journal Title: Br J Cancer Volume: 105(9) Issue: 9 Pages: 1331-1337
  • DOI: 10.1038/bjc.2011.399
  • Peer Reviewed
• [Journal Article] Phosphorylated Akt up-regulates angiotensin II type-1 receptor expression in castration resistant prostate cancer (2011)
  • Author(s): Kosaka T, Miyajima A, 他4名
  • Journal Title: Journal of Urology Volume: 185(6) Pages: 2376-2381
  • Peer Reviewed
• [Journal Article] Phosphorylated Akt up-regulates angiotensin II type-1 receptor expression in castration resistant prostate cancer. (2011)
  • Author(s): Takeo Kosaka, Akira Miyajima, et al
  • Journal Title: The Prostate Volume: (in press)
  • Peer Reviewed
• [Journal Article] Low dose docetaxel enhances the sensitivity of S-1 in a xenograft model of human castration resistant prostate cancer. (2011)
  • Author(s): Masanori Hasegawa, Akira Miyajima, et al
  • Journal Title: International Journal of Cancer Volume: (in press)
  • Peer Reviewed
• [Journal Article] Long-term androgen ablation and treatment with Docetaxel up-regulate phosphorylated Akt in Castration Resistant Prostate Cancer (2011)
  • Author(s): Takeo Kosaka, Akira Miyajima, et al
  • Journal Title: The Journal of Urology Volume: (in press)
  • Peer Reviewed
• [Presentation] PI3K-Akt-mTORシグナル経路の制御による去勢抵抗性前立腺癌のドセタキセル抵抗性改善に関する検討 (2013)
  • Author(s): 安水洋太、宮嶋哲、小坂威雄、宮崎保匡、菊地栄次、大家基嗣
  • Organizer: 第22回泌尿器科分子・細胞研究会
  • Place of Presentation: 高知
  • Year and Date: 2013-03-09
• [Presentation] 前立腺癌におけるMCP-1発現の臨床的意義 (2012)
  • Author(s): 宮嶋哲、城武卓、小坂威雄、菊地栄次、中川健、大家基嗣
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-10-26
• [Presentation] 去勢抵抗性前立腺癌における各種遺伝子異常 (2012)
  • Author(s): 小坂威雄、宮嶋哲、菊地栄次、長田浩彦、中川健、大家基嗣
  • Organizer: 第19回東京前立腺癌フォーラム「去勢抵抗性前立腺癌の治療戦略～内分泌療法の可能性と限界」
  • Place of Presentation: 東京
  • Year and Date: 2012-10-06
• [Presentation] Combination Therapy with PI3K-mTOR Pathway Inhibitor and Docetaxel in Castration Resistant Prostate Cancer (2012)
  • Author(s): 安水洋太、宮嶋哲、小坂威雄、城武卓、菊地栄次、大家基嗣
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] 前立腺癌におけるMCP-1の発現制御に関する検討 (2012)
  • Author(s): 宮嶋哲、城武卓、小坂威雄、菊地栄次、大家基嗣
  • Organizer: 第16回学術集会日本がん分子標的治療学会
  • Place of Presentation: 北九州
  • Year and Date: 2012-06-28
• [Presentation] 去勢抵抗性前立腺癌に対するPI3K・mTORC1/2阻害剤とドセタキセル併用効果についての検討 (2012)
  • Author(s): 安水洋太、宮嶋哲、小坂威雄、城武卓、菊地栄次、大家基嗣
  • Organizer: 第16回学術集会日本がん分子標的治療学会
  • Place of Presentation: 北九州
  • Year and Date: 2012-06-28
• [Presentation] Long-term androgen ablation and treatment with taxanes up-regulate phosphorylated akt in castration resistant prostate cancer (2012)
  • Author(s): Kosaka T., Miyajima A., Shirotake S., Kikuchi E., Oya M
  • Organizer: The107th American Urological Association Annual Meeting
  • Place of Presentation: Atlanta
  • Year and Date: 2012-05-21
• [Presentation] Regulation of MCP-1 expression through angiotensin ll type1 receptor in castration-resistant prostate cancer. (2012)
  • Author(s): Shirotake S., Miyajima A., Kosaka T., Tanaka N., Kikuchi E., Oya M.
  • Organizer: The107th American Urological Association Annual Meeting.
  • Place of Presentation: Atlanta
  • Year and Date: 2012-05-21
• [Presentation] P13K/AKT dual inhibitor restores docetaxel sensitivity in castration resistant prostate cancer. (2012)
  • Author(s): Yasumizu Y., Miyajima A., Kosaka T., Shirotake S., Kikuchi E., Oya M.
  • Organizer: The107th American Urological Association Annual Meeting.
  • Place of Presentation: Atlanta
  • Year and Date: 2012-05-21
• [Presentation] 去勢抵抗性前立腺癌に対するPI3K・mTORC1/2阻害剤とドセタキセル併用効果についての検討 (2012)
  • Author(s): 安水洋太、宮嶋哲、小坂威雄、城武卓、菊地栄次、大家基嗣
  • Organizer: 第21回泌尿器科分子・細胞研究会
  • Place of Presentation: 北海道
  • Year and Date: 2012-02-11
• [Presentation] 去勢抵抗性前立腺癌に対するPI3K・mTORC1/2阻害剤とドセタキセル併用効果についての検討 (2012)
  • Author(s): 安水洋太、宮嶋哲, 他4名
  • Organizer: 第21回泌尿器科分子・細胞研究会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-02-11
• [Presentation] How does 5α-reductase activity change during the progression of castration resistant prostate cancer ? (2012)
  • Author(s): Kosaka T
  • Organizer: Annual meeting of Am Urol Assoc
  • Place of Presentation: Atlanta, USA
• [Presentation] Regulation of MCP-1 expression through angiotensin II type 1 receptor in castration-resistant prostate cancer． (2012)
  • Author(s): Shirotake S
  • Organizer: Annual meeting of Am Urol Assoc
  • Place of Presentation: Atlanta, USA
• [Presentation] 去勢抵抗性前立腺癌における進展のプロセスと、微小環境に着目した包括的治療戦略 (2011)
  • Author(s): 小坂威雄、宮嶋哲、菊地栄次、城武卓、大家基嗣
  • Organizer: 第27回前立腺シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-12-10
• [Presentation] 去勢抵抗性前立腺癌における進展のプロセスと、微小環境に着目した包括的治療戦略 (2011)
  • Author(s): 小坂威雄、宮嶋哲, 他3名
  • Organizer: 第27回前立腺シンポジウム
  • Place of Presentation: 東京コンファレンスセンター(東京)
  • Year and Date: 2011-12-10
• [Presentation] 長期間のアンドロゲン除去ならびにドセタキセル投与のAktのリン酸化 (2011)
  • Author(s): 小坂威雄、宮嶋哲, 他4名
  • Organizer: 第20回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-10-04
• [Presentation] 去勢抵抗性前立腺癌において、PI3K/Aktシグナル経路は進展に伴い更に活性化される (2011)
  • Author(s): 小坂威雄、宮嶋哲、菊地栄次、城武卓、大家基嗣
  • Organizer: 日本がん分子標的治療学会第15回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-24
• [Presentation] 去勢抵抗性前立腺癌におけるangiotensin II type 1 receptor を介したCCL2の発現制御の検討 (2011)
  • Author(s): 城武卓、宮嶋哲、小坂威雄、菊地栄次、大家基嗣
  • Organizer: 日本がん分子標的治療学会第15回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-24
• [Presentation] 去勢抵抗性前立腺癌において、PI3K/Aktシグナル経路は進展に伴い更に活性化される (2011)
  • Author(s): 小坂威雄、宮嶋哲, 他3名
  • Organizer: 日本がん分子標的治療学会第15回学術集会
  • Place of Presentation: ホテル日航東京(東京)
  • Year and Date: 2011-06-24
• [Presentation] 去勢抵抗性前立腺癌におけるangiotensin II type 1 receptorを介したCCL2の発現制御の検討 (2011)
  • Author(s): 城武卓、宮嶋哲, 他3名
  • Organizer: 日本がん分子標的治療学会第15回学術集会
  • Place of Presentation: ホテル日航東京(東京)
  • Year and Date: 2011-06-24
• [Presentation] Angiotensin II type 1 receptor and microvessel density predict the early intravesical recurrence in bladder cancer (2011)
  • Author(s): 城武卓、宮嶋哲, 他5名
  • Organizer: The106th American Urological Association Annual Meeting
  • Place of Presentation: Washington Convention Center, Washington DC, U.S.A.
  • Year and Date: 2011-05-17
• [Presentation] Prediction and stratification of the development of urinary retention patients with locally advanced prostate cancer treated with hormone therapy (2011)
  • Author(s): 長谷川政徳、宮嶋哲, 他5名
  • Organizer: The106th American Urological Association Annual Meeting
  • Place of Presentation: Washington Convention Center, U.S.A.
  • Year and Date: 2011-05-16
• [Presentation] Reactive oxygen species generation inceased by cisdechlorodiamm ineplatinum enhances VEGF production through upregulating an giotensin II type1 receptor in bladder cancer (2011)
  • Author(s): 田中伸之、宮嶋哲, 他5名
  • Organizer: The106th American Urological Association Annual Meeting
  • Place of Presentation: Washington Convention Center, Washington DC, U.S.A.
  • Year and Date: 2011-05-16
• [Presentation] Clinical significance of snail expression in bladder tumor and its hypoxic resrulation (2011)
  • Author(s): 小坂威雄、宮嶋哲, 他5名
  • Organizer: The106th American Urological Association Annual Meeting
  • Place of Presentation: Washington Convention Center, Washington DC, U.S.A.
  • Year and Date: 2011-05-16
• [Presentation] Low dose docetaxel enhances the sensitivity of S-1 in axenogaft model of human castration resistant prostate cancer (2011)
  • Author(s): 長谷川政徳、宮嶋哲, 他8名
  • Organizer: The106th American Urological Association Annual Meeting
  • Place of Presentation: Washington Convention Center, Washington DC, U.S.A.
  • Year and Date: 2011-05-16
• [Presentation] 去勢抵抗性前立腺癌(CRPC)はその進展過程において、どのようにその難治性の形質を獲得するのか? (2011)
  • Author(s): 小坂威雄、宮嶋哲、城武卓、前田高宏、菊地栄次、大家基嗣
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-24
• [Presentation] 去勢抵抗性前立腺癌における5-FU系経口抗癌剤S-1の抗腫瘍効果と低用量ドセタキセル併用による増強効果の機構解明 (2011)
  • Author(s): 長谷川政徳、宮嶋哲、小坂威雄、安水洋太、井手広樹、菊地栄次、大家基嗣
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-24
• [Presentation] 去勢抵抗性前立腺癌(CRPC)はその進展過程において、どのようにその難治性の形質を獲得するのか? (2011)
  • Author(s): 小坂威雄、宮嶋哲, 他4名
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-04-24
• [Presentation] 去勢抵抗性前立腺癌における5-FU系経口抗癌剤S-1の抗腫瘍効果と低用量ドセタキセル併用による増強効果の機構解明 (2011)
  • Author(s): 長谷川政徳、宮嶋哲, 他5名
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-04-24
• [Presentation] 膀胱癌におけるアンギオテンシンII1型受容体発現と微小血管密度の臨床的意義に関する検討 (2011)
  • Author(s): 城武卓、宮嶋哲, 他5名
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2011-04-22
• [Presentation] 前立腺癌におけるレニン-アンギオテンシン系を介したMCP‐1の発現制御についての検討 (2011)
  • Author(s): 城武卓、宮嶋哲、小坂威雄、田中伸之、菊地栄次、大家基嗣
  • Organizer: 第11回関東ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-29
• [Presentation] 前立腺癌に対する低用量ドセタキセルによるthymidylate synthaseの発現を低下させることで5-FUの感受性を亢進する (2010)
  • Author(s): 長谷川政徳、宮嶋哲, 他5名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 前立腺癌におけるAT1Rを介したCCL2の発現制御 (2010)
  • Author(s): 城武卓、宮嶋哲, 他3名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 去勢抵抗性前立腺癌(CRPC)の進展過程に着目した実験系の提唱とその意義 (2010)
  • Author(s): 小坂威雄、宮嶋哲, 他3名
  • Organizer: 日本アンドロロジー学会第29回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-31
• [Presentation] 前立腺癌におけるCCL2の発現とangiotensin II type 1 receptor blockadeの効果についての検討 (2010)
  • Author(s): 城武卓、宮嶋哲, 他3名
  • Organizer: 日本がん分子標的治療学会第14回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-08
• [Presentation] Functional analysis of miRNA in tumor microenvironment as a key regulator of aggressive angiogenesis ofhormone-refractory prostate cancer (2010)
  • Author(s): Takeo Kosaka, Akira Miyajima, et al
  • Organizer: The 105^<th> American Urological Association Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 2010-05-30
• [Presentation] How does ets family contribute to prostate cancer progression? (2010)
  • Author(s): Takeo Kosaka, Akira Miyajima, et al
  • Organizer: The 105^<th> American Urological Association Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 2010-05-30
• [Presentation] ホルモン不応性前立腺癌における、HIF-1aとEts-1の抑制を介した、アンギオテンシII-1型受容体阻害剤(ARB)による血管新生制御機構の解明 (2010)
  • Author(s): 小坂威雄、宮嶋哲, 他5名
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-28
• [Presentation] 前立腺癌細胞に対するドセタキセルによるthymidylate synthase発現抑制の機序についての検討 (2010)
  • Author(s): 長谷川政徳、宮嶋哲, 他5名
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 岩手
  • Year and Date: 2010-04-27
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