Analysis of mechanism of intravesical BCG therapy for bladder cancer

• Project/Area Number: 22591780
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nippon Medical School
• Principal Investigator: TAKAHASHI Hidemi 日本医科大学, 大学院・医学研究科, 教授 (40221361)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 樹状細胞(DC) / BCG / DEC-205陽性DC / 共刺激分子 / NKT細胞 / γδ型T細胞 / ランゲルハンス細胞（LC) / γδ型Ｔ細胞 / LAM / MHC / 共刺激分子群 / γσ型T細胞 / CD1

Research Abstract

Intravesical bacillus Calmette-Guerin (BCG) therapy is considered the most successful immunotherapy against solid tumor of human bladder carcinoma, but the precise anti-tumor mechanism is still unknown. BCG-susceptible dendritic cells (DCs) have been thought as key cells to induce tumor-specific immunity. However, because these DCs will not be tumorcells generally and thus, they can present antigenic molecule obtained from external tumors via class II MHC molecules, by which tumor-specific class-I MHC molecule-restricted CD8-positive cytotoxoc T lymphocytes (CTLs) will not be generated. Nevertheless, recent findings demonstrated that DC-subpopulation expressing DEC-205 can present captured antigenic molecules associated with their class I MHC by “cross-presentation”. In this study, we found that we could selectively activate DEC-205-expressing DCs when they were stimulated with viable BCG. Because such viable BCG seems to be toxic to DCs, we have currently examined the non-toxic components of BCG such as micolic acid or lipoaravinomannan (LAM) and found that these BCG-derived components have a potency to stimulate DEC-205-positive DCs. Based on the observation, we are trying to provide a new safer immunotherapy for human bladder carcinoma.

Research Products

• [Journal Article] Induction of rapid apoptosis for class I MHC molecule-restricted CD8+ HIV-1 gp160-specific murine activated CTLs by free antigenic peptide in vivo (2013)
  • Author(s): Nakagawa, Y., Shimizu, M., Norose, Y., Takahashi, M., and Takahashi, H
  • Journal Title: Int. Immunol Volume: 25(1) Pages: 11-24
• [Journal Article] E-cadherin interactions are required forLangerhans cell differentiation. (2013)
  • Author(s): Mayumi, N., Watanabe, E., Norose, Y., Watari, E., Kawana, S., Geijtenbeek, T.B., and Takahashi, H
  • Journal Title: Eur.J. Immunol Volume: 43(1) Pages: 270-280
• [Journal Article] Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma (2013)
  • Author(s): Tamura, H., Ishibashi, M., Tonosaku, S., Okuyama, N., Kondo, A., Hyodo, H., Shinya, E., Takahashi, H., Dong, H., Tamada, K., Chen, L., Dan, K., and Ogata, K
  • Journal Title: Leukemia Volume: 27(2) Pages: 464-472
• [Journal Article] Induction ofapoptosis-resistant andTGF-β-insensitive murine CD8+ CTLs specific for HIV-1 gp160. (2013)
  • Author(s): Takaku, S., Nakagawa, Y., Owaki, A., Shimizu, M., Takahashi, M., and Takahashi, H.
  • Journal Title: Cell. Immunol Volume: 280(2) Pages: 138-147
• [Journal Article] Requirement of E-cadherin interactions for Langerhans cell differentiation. (2013)
  • Author(s): Takahashi, H., Mayumi, N., and Watanabe, E.
  • Journal Title: J. Nippon Medical School Volume: 80(2)(in press)
  • NAID: 130004147220
• [Journal Article] 丸山ワクチンの新展開 (2013)
  • Author(s): 高橋秀実
  • Journal Title: 遙か Volume: 8(1) Pages: 39-43
• [Journal Article] 免疫と漢方 (2013)
  • Author(s): 高橋秀実
  • Journal Title: 黄帝内経に啓示された古代人の智慧日本東洋医学会雑誌 Volume: 64(1) Pages: 1-9
• [Journal Article] Induction of rapid apoptosis for class I MHC molecule-restricted CD8+ HIV-1 gp160-specific murine activated CTLs by free antigenic peptide in vivo. (2013)
  • Author(s): Nakagawa, Y.
  • Journal Title: Int. Immunol. Volume: 25 Pages: 11-24
  • DOI: 10.1093/intimm/dxs086
  • Peer Reviewed
• [Journal Article] E-cadherin interactions are required for Langerhans cell differentiation. (2013)
  • Author(s): Mayumi, N.
  • Journal Title: Eur. J. Immunol. Volume: 43 Pages: 270-280
  • DOI: 10.1002/eji.201242654
  • Peer Reviewed
• [Journal Article] Marrow stromal cells induce B7-H1 expression on myeloma cells, generating aggressive characteristics in multiple myeloma. (2013)
  • Author(s): Tamura, H.
  • Journal Title: Leukemia Volume: 27 Pages: 464-472
  • DOI: 10.1038/leu.2012.213
  • Peer Reviewed
• [Journal Article] Induction of apoptosis-resistant and TGF-β-insensitive murine CD8+ CTLs specific for HIV-1 gp160. (2013)
  • Author(s): Takaku, S.
  • Journal Title: Cellular Immunology Volume: 280 Pages: 138-147
  • DOI: 10.1016/j.cellimm.2012.12.008
  • Peer Reviewed
• [Journal Article] C. Ribavirin downmodulates inducible costimulator on CD4+ T cells and their interleukin-10 secretion to assist in hepatitis C virus clearance. (2012)
  • Author(s): Atsukwa, M., Nakatsuka, K., Kobayashi, T., Shimizu, M., Tamura, H., Harimoto, H., Takahashi, H.and Sakamoto
  • Journal Title: J. Gastroenterol. Hepatol Volume: 27(4) Pages: 823-831
• [Journal Article] HTLV-I-infected breast milk macrophages inhibit monocyte differentiation to dendritic cells (2012)
  • Author(s): Inagaki, S., Takahashi, M., Fukunaga, Y., and Takahashi, H
  • Journal Title: Viral. Immunol Volume: 25(2) Pages: 106-116
• [Journal Article] Disruption of maternal immune balance maintained by innate DC subsets results in spontaneous pregnancy loss in mice. (2012)
  • Author(s): Negishi, Y., Wakabayashi, A., Shimizu, M., Ichikawa, T., Kumagai, Y., Takeshita, T., and Takahashi, H
  • Journal Title: Immunobiology Volume: 217(10) Pages: 951-961
• [Journal Article] C. Ribavirin modulates the conversion of human CD4(+) CD25(-) T cell to CD4(+) CD25(+) FOXP3(+) T cell (2012)
  • Author(s): Kobayashi, T., Nakatsuka, K., Shimizu, M., Tamura, H., Shinya, E., Atsukawa, M., Harimoto, H., Takahashi, H. and Sakamoto
  • Journal Title: Immunology Volume: 137(3) Pages: 259-270
• [Journal Article] HIVと闘う宿主防御因子 (2012)
  • Author(s): 村上努、高橋秀実
  • Journal Title: 日本エイズ学会誌 Volume: 14(1) Pages: 1-2
• [Journal Article] ヒト免疫不全ウイルスHIV-1のNefによる樹状細胞CD1脂質 抗原提示機能の低下 (2012)
  • Author(s): 新谷英滋、 高橋 秀実
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(2) Pages: 269-274
• [Journal Article] 第25回日本エイズ学会シン ポジウム記録:エイズウイルスの侵入・ 棲息部位である粘膜組織におけるウイ ルス制御法を探る (2012)
  • Author(s): 高橋秀実
  • Journal Title: 日本エイズ学会誌 Volume: 14(2) Pages: 11-14
• [Journal Article] HIV感染制御における新たな標的としての自然免疫 (2012)
  • Author(s): 高橋秀実
  • Journal Title: 日本エイズ学会誌 Volume: 14(2) Pages: 15-19
• [Journal Article] HIVワクチン開発のための新たな指標. (2012)
  • Author(s): 高橋秀実
  • Journal Title: セフィーロ Volume: 5 Pages: 1-8
• [Journal Article] ピロリ菌と自己免疫 (2012)
  • Author(s): 高橋秀実
  • Journal Title: 臨床免疫・アレルギー科 Volume: 58(3) Pages: 355-360
  • NAID: 40019440062
• [Journal Article] Cross-presentation. (2012)
  • Author(s): 高橋秀実
  • Journal Title: 炎症と免疫 Volume: 20(6) Pages: 638-641
• [Journal Article] Ribavirin modulates the conversion of human CD4(+) CD25(-) T cell to CD4(+) CD25(+) FOXP3(+) T cell via suppressing interleukin-10-producing regulatory T cell. (2012)
  • Author(s): Kobayashi, T.
  • Journal Title: Immunology Volume: 137 Pages: 259-270
  • DOI: 10.1111/imm.12005
  • Peer Reviewed
• [Journal Article] Ribavirin down-modulate ICOS on CD4+ T-cells and the interleukin-10 secretion to assist clearance of hepatitis C virus (2012)
  • Author(s): Atsukawa, M., Nakatsuka, K., Kobayashi, T., Shimizu, M., Harimoto, H., Takahashi, H., Sakamoto, C.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 26 Pages: 823-831
  • DOI: 10.1111/j.1440-1746.2011.06882.x
  • Peer Reviewed
• [Journal Article] HTLV-I-infected breast milk macrophages inhibit monocyte differentiation to dendritic cells (2012)
  • Author(s): Inagaki, S., Takahashi, M., Fukunaga, Y, Takahashi, H.
  • Journal Title: Viral. Immunol. Volume: 25 Pages: 106-116
  • DOI: 10.1089/vim.2011.0069
  • Peer Reviewed
• [Journal Article] Disruption of maternal immune balance maintained by innate DC subsets results in spontaneous pregnancy loss in mice (2012)
  • Author(s): Negishi, Y., Wakabayashi, A., Shimizu, M., Ichikawa, T., Kumagai, Y., Takeshita, T., Takahashi, H.
  • Journal Title: Immunobiology Volume: 217(Jan 13, 2012 on line published) Pages: 951-961
  • DOI: 10.1016/j.imbio.2012.01.011
  • Peer Reviewed
• [Journal Article] One-step simple assay to determine antigen-specific cytptoxic activities by single-color flow cytometry (2011)
  • Author(s): Nakagawa, Y., Watari, E., Shimizu, M., and Takahashi, H.
  • Journal Title: Biomedical Res Volume: 32(2) Pages: 159-166
• [Journal Article] Induction of CD56+ T cells after prolonged activation of T cells in vitro: a possible mechanism for CD4+ T-cell depletion in acquired immune deficiency syndrome patients. (2011)
  • Author(s): Takahashi, M., Matsumura, J., Inagaki, S., and Takahashi, H.
  • Journal Title: Human Immunol Volume: 72 Pages: 783-790
• [Journal Article] Production of Auto-antibodies by Murine B-1a Cells Stimulated with Helicobacter pylori Urease through TLR2 Signaling (2011)
  • Author(s): Kobayashi, F., Watanabe, E., Nakagawa, Y., Yamanishi, S., Norose, Y., Fukunaga, Y., and Takahashi, H
  • Journal Title: Infect. Immun Volume: 79 Pages: 4791-4801
• [Journal Article] Characterization of recombinant Streptococcus mitis-derived human platelet aggregation factor. (2011)
  • Author(s): Ohkuni, H., Nagamune, H., Ozaki, N., ,Tabata, A., Todome, Y., Watanabe,Y., Takahashi, H., Ohkura, K., Kourai, H., Ohtsuka, H., Fischetti, V.A., and Zabriskie, J.B.
  • Journal Title: APMIS Volume: 120 Pages: 56-71
• [Journal Article] 宿主免疫応答と各種病態. (2011)
  • Author(s): 高橋秀実
  • Journal Title: 臨床と微生物 Volume: 38 Pages: 9-14
• [Journal Article] 漢方医学と近代医学との接点:免疫と漢方 (2011)
  • Author(s): 高橋秀実
  • Journal Title: これからの漢方医学 (からだの科学増刊号)
• [Journal Article] One-Step simple assay to determine antigen-specific cytotoxic activities by single-color flow cytometry (2011)
  • Author(s): Nakagawa, Y., Watari, E., Shimizu, M., Takahashi, H.
  • Journal Title: Biomed.Res. Volume: 32 Pages: 159-166
  • NAID: 130004470776
  • Peer Reviewed
• [Journal Article] Induction of CD56+ T cells after prolonged activation of T cells in vitro : a possible mechanism for CD4+ T cell depletion in acquired immune deficiency syndrome patients (2011)
  • Author(s): Takahashi, M., Matsumura, J., Inagaki, S., Takahashi, H.
  • Journal Title: Human Immunol. Volume: 72 Pages: 783-790
  • DOI: 10.1016/j.humimm.2011.06.001
  • Peer Reviewed
• [Journal Article] Production of auto-antibodies by murine B-1a cells stimulated with Helicobacter pylori urease through TLR2 signaling (2011)
  • Author(s): Kobayashi, F., Watanabe, E., Nakagawa, Y., Yamanishi, S., Norose, Y., Fukunaga, Y., Takahashi, H.
  • Journal Title: Infect Immun. Volume: 79 Pages: 4791-4801
  • Peer Reviewed
• [Journal Article] Characterization of recombinant Streptococcus mitius-derived human platelet aggregation factor (2011)
  • Author(s): Ohkuni, H., Nagaume, H., Ozaki, N., Tabata, A., Todome, Y., Watanabe, Y., Takahashi, H., Fischetti H., Zabriskie, J.B.
  • Journal Title: APMIS Volume: 120 Pages: 56-71
  • Peer Reviewed
• [Journal Article] One-step simple assay to determine antigen-specific cytotoxic activities by single-color flow cytometry. (2011)
  • Author(s): Nakagawa, Y., Watari, E., Shimizu, M., Takahashi, H.
  • Journal Title: Biomed.Res. Volume: 32 Pages: 159-166
  • NAID: 130004470776
  • Peer Reviewed
• [Journal Article] Species-specificCD1-restricted innate immunity for the development of HIV vaccine. (2010)
  • Author(s): Takahashi, H.
  • Journal Title: Vaccine Volume: 28S
• [Journal Article] Transformation of breast milk macrophages by HTLV-I: implications for HTLV-I transmission via breastfeeding. (2010)
  • Author(s): Takeuchi, H., Takahashi, M., Norose, Y.,Takeshita, T., Fukunaga, Y., K., Takahashi, H.
  • Journal Title: Biomedical Res. Volume: 31 Pages: 53-61
  • NAID: 130004903783
• [Journal Article] Development of anti-tumor immunity by oral vaccination with tumor antigen and cholera toxin (2010)
  • Author(s): Wakabayashi, A., Nakagawa, Y., Shimizu, M., Takahashi, H
  • Journal Title: J. Nippon Med. Sch Volume: 77 Pages: 50-52
  • NAID: 130004147029
• [Journal Article] Small intestine CD4+ cell reduction and enteropathy in SHIV-KS661-infected rhesus macaques in presence of low viral load. (2010)
  • Author(s): Inaba, K., Fukazawa, Y., Matsuda, K., Himeno, A., Matsuyama, M., Ibuki, K., Miura, Y., Koyanagi, Y., Nakajima, A., Blumberg, R. S., Takahashi, H., Hayami, M., Igarashi, T., Miura, T.
  • Journal Title: J. Gen. Virol Volume: 91 Pages: 773-781
• [Journal Article] Effect of probiotic bacterial strains of Lactobacillus, Bifidobacterium and Enterococcus on enteroaggregative Echerichia coli. (2010)
  • Author(s): Miyazaki, Y, Kamiya, S., Hanawa, T., Fukuda, M., Kawakami, H., Takahashi, H., Yokota, H.
  • Journal Title: J. Infect. Chemother Volume: 16 Pages: 10-18
• [Journal Article] Inhibition ofDC-SIGN-mediated transmission ofHIV-1 by TLR3 signaling in breast milk macrophages (2010)
  • Author(s): Yagi, Y., Watanabe, E., Watari, E., Shinya, E., Satomi, M., Takeshita, T., Takahashi, H.
  • Journal Title: Immunology Volume: 130 Pages: 597-607
• [Journal Article] Induction of tumor-specific acquired immunity against already established tumors by selective stimulation of innate DEC-205(+) dendritic cells. (2010)
  • Author(s): Moriya, K., Wakabayashi, A., Shimizu, M., Tamiura, H., Dan, K., Takahashi, H.
  • Journal Title: Cancer Immunol. Immunother Volume: 59 Pages: 1083-1095
• [Journal Article] Interferon- gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes (2010)
  • Author(s): Kondo, A, Yamashita, T., Tamura, H., Zhao, W., Tsuji, T., Shimizu, M., Shinya, E., Takahashi, H., Tamada, K., Chen, L., Dan, K., Ogata, K
  • Journal Title: Blood Volume: 116 Pages: 1124-1131
• [Journal Article] 免疫力による未病のガンの制御. (2010)
  • Author(s): 高橋秀実
  • Journal Title: 未病と抗老化 Volume: 19 Pages: 24-28
• [Journal Article] 手の衛生手 技は透析液の清浄化に不可欠である. (2010)
  • Author(s): 本田和美, 井上有紀, 大薗英一, 野呂瀬嘉彦, 高 橋秀実 , 葉山修陽
  • Journal Title: 日本透析医学会誌 Volume: 43(4) Pages: 361-366
• [Journal Article] Species-specific CD1-restricted innate immunity for the development of HIV vaccine. (2010)
  • Author(s): Takahashi, H.
  • Journal Title: Vaccine Volume: 28
  • Peer Reviewed
• [Journal Article] Transformation of breast milk macrophages by HTLV-I : implications for HTLV-I trans-mission via breastfeeding. (2010)
  • Author(s): Takeuchi, H., Takahashi, M., Norose, Y., Takeshita, T., Fukunaga, Y., K., Takahashi, H.
  • Journal Title: Biomedical Res. Volume: 31 Pages: 53-61
  • Peer Reviewed
• [Journal Article] Small intestine CD4+ cell reduction and enteropathy in SHIV-KS661-infected rhesus macaques in presence of low viral load. (2010)
  • Author(s): Inaba, K., Fukazawa, Y., Matsuda, K., Himeno, A., Matsuyama, M., Ibuki, K., Miura, Y., Koyanagi, Y., Nakajima, A., Blumberg, R.S., Takahashi, H., Hayami, M., Igarashi, T., Miura, T
  • Journal Title: J.Gen Virol. Volume: 91 Pages: 773-781
  • Peer Reviewed
• [Journal Article] Inhibition of DC-SIGN-mediated transmission of HIV-1 by TLR3 signaling in breast milk macrophages. (2010)
  • Author(s): Yagi, Y., Watanabe, E., Watari, E., Shinya, E., Satomi, M., Takeshita, T., Takahashi, H.
  • Journal Title: Immunology Volume: 130 Pages: 597-607
  • Peer Reviewed
• [Journal Article] Induction of tumor-specific acquired immunity against already established tumors by selective stimulation of innate DEC-205(+)dendritic cells. (2010)
  • Author(s): Moriya, K., Wakabayashi, A., Shimizu, M., Tamiura, H., Dan, K., Takahashi, H.
  • Journal Title: Cancer Immunol Immunother. Volume: 59 Pages: 1083-1195
  • Peer Reviewed
• [Journal Article] Interferon- gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. (2010)
  • Author(s): Kondo, A, Yamashita, T., Tamura, H., Zhao, W., Tsuji, T., Shimizu, M., Shinya, E., Takahashi, H., Tamada, K., chen, L., Dan, K., Ogata, K.
  • Journal Title: Blood Volume: 116 Pages: 1124-1131
  • Peer Reviewed
• [Presentation] 丸山ワクチン作用機序に関する新たな知見 (2013)
  • Author(s): 高橋秀実
  • Organizer: 第76回日本皮膚科学会東京支部会学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] In vivo inhibition of HIV-1-specific apoptosis induced by brief exposure to viral epitope. (2013)
  • Author(s): Takahashi, H.
  • Organizer: Japan-US Cooperative Medical Science Program: The 26th Joint Scientific Meeting of AIDS Panels.
  • Place of Presentation: シンガポール
• [Presentation] Suppression of virus replication within HIV-1-infected mucosal innate immuno-competent cells. (2013)
  • Author(s): Takahashi, H.
  • Organizer: Japan-US Cooperative Medical Science Program: The 26th Joint Scientific Meeting of AIDS Panels.
  • Place of Presentation: シンガポール
• [Presentation] 丸山ワクチンによる自然免疫の活性化 (2012)
  • Author(s): 高橋秀実
  • Organizer: 第10回NPO「丸山ワクチンとがんを考える会」
  • Place of Presentation: 東京
  • Invited
• [Presentation] 自然免疫と獲得免疫 (2012)
  • Author(s): 高橋秀実
  • Organizer: 第29回和漢医薬学会学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 自己免疫性肝炎、SLEに合併した血小板減少性紫斑病に奏功した温病をベースとした東洋医学的治療 (2012)
  • Author(s): 高橋秀実
  • Organizer: 第29回和漢医薬学会学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Control of HIV infection and dissemination at the mucosal compartments (2011)
  • Author(s): Takahashi, H.
  • Organizer: 第25回日本エイズ学会学術集会シンポジウム
  • Place of Presentation: Tokyo, Japan(招待講演)
  • Year and Date: 2011-12-01
• [Presentation] 母乳を介したHIV感染伝播に関する免疫学 (2011)
  • Author(s): 高橋秀実
  • Organizer: 第25回日本エイズ学会学術集会セミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-30
• [Presentation] 漢方医学と最新の免疫学 (2011)
  • Author(s): 高橋秀実
  • Organizer: 東京女子医科大学東洋医学研究所
  • Place of Presentation: 東京(特別講演)
  • Year and Date: 2011-10-20
• [Presentation] 丸山ワクチンの作用機序に対する新たな視点 (2011)
  • Author(s): 高橋秀実
  • Organizer: がんプロフェッショナル養成プランセミナー
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-10-01
• [Presentation] Uptake and Dissemination of HIV by mucosal innate cells (2011)
  • Author(s): Takahashi, H.
  • Organizer: Japan-US Coopeprative Medical Science Program : The 25^<th> Joint Scientific Meeting of AIDS Panels
  • Place of Presentation: Atlanta, USA(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] 日本医科大学での「卒前から初期研修」までの東洋医学教育の現状と展望 (2011)
  • Author(s): 高橋秀実
  • Organizer: KAMPO MEDICAL SYMPOSIUM 2011 (シンポジスト)
  • Place of Presentation: 東京
  • Year and Date: 2011-02-05
• [Presentation] 感染症に対する生体応答と各種の症候 (2010)
  • Author(s): 高橋秀実
  • Organizer: 第23回日本外科感染症学会総会学術集会
  • Place of Presentation: 東京(特別講演)
  • Year and Date: 2010-11-18
• [Presentation] 自然免疫を介した生体応答と様々な症候:漢方薬の新たな作用点 (2010)
  • Author(s): 高橋秀実
  • Organizer: 平成22年度日本東洋医学会東京都部会
  • Place of Presentation: 東京(特別講演)
  • Year and Date: 2010-10-31
• [Presentation] 日本医科大学における東洋医学に関する教育の現状と展望 (2010)
  • Author(s): 高橋秀実
  • Organizer: 第42回日本医学教育学会大会
  • Place of Presentation: 東京(特別講演)
  • Year and Date: 2010-07-29
• [Presentation] エイズの現況と対策 (2010)
  • Author(s): 高橋秀実
  • Organizer: 第20回日本医科大学医学会公開シンポジウムシンポジスト
  • Place of Presentation: 東京
  • Year and Date: 2010-06-12
• [Presentation] Selective activation of species-restricted innate immunity for the development of individually restricted acquired immunity (2010)
  • Author(s): Takahashi, H.
  • Organizer: World Immune Regulation Meeting-IV(第4回国際免疫制御学会シンポジスト)
  • Place of Presentation: Davos, Switzerland
  • Year and Date: 2010-04-01
• [Book] 後天性免疫不全症候群. 血液 症候群(別冊日本臨床) (2013)
  • Author(s): 高橋秀実
  • Publisher: 日本臨床社編
• [Book] その他の二次性免疫不全症候 群 . 血液症候群(別冊日本臨床) (2013)
  • Author(s): 高橋秀実
  • Total Pages: 623
  • Publisher: 日本臨床社編
• [Book] 血液症候群（別冊日本臨床） (2013)
  • Author(s): 高橋秀実
  • Total Pages: 623
  • Publisher: 日本臨床社
• [Book] 第17章「免疫応答不全」、微生物学 (2012)
  • Author(s): 高橋秀実
  • Publisher: メディカル・サイエンス・イ ンターナショナル社編
• [Book] 微生物学 (2012)
  • Author(s): 高橋秀実
  • Total Pages: 664
  • Publisher: メディカル・サイエンス・インターナショナル社
• [Book] H. Co-operation of innate and acquired immunity for controlling tumor cells. In "Melanoma in The Clinic". (2011)
  • Author(s): Takahashi
  • Total Pages: 310
  • Publisher: Ed. Murph. M
• [Book] Co-operation of innate and acquired immunity for controlling tumor cells. (In Melanoma in The Clinic) (2011)
  • Author(s): Takahashi, H.
  • Total Pages: 310
  • Publisher: INTEC
• [Book] 免疫応答不全(微生物学) (2011)
  • Author(s): 高橋秀実
  • Total Pages: 310
  • Publisher: メディカル・サイエンス・インターナショナル社
• [Book] [分担]細胞性免疫(CTL)の誘導と樹状細胞 (2010)
  • Author(s): 高橋秀実
  • Publisher: 臨床粘膜免疫学(清野宏)
• [Book] 臨床粘膜免疫学(分担)(清野宏監修) (2010)
  • Author(s): 高橋秀実
  • Total Pages: 723
  • Publisher: シナジー
• [Patent(Industrial Property Rights)] ランゲルハンス細胞の調整方法 (2012)
  • Inventor(s): 高橋秀実
  • Industrial Property Rights Holder: 高橋秀実
  • Filing Date: 2012-05-24
• [Patent(Industrial Property Rights)] ランゲルハンス細胞の調製方法 (2012)
  • Inventor(s): 高橋秀実
  • Industrial Property Rights Holder: 高橋秀実＆住友ベークライト社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-118666
  • Filing Date: 2012-05-24