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Combined therapy for urologic cancer cells by high-intensity focused ultrasound and PEG-conjugated fullerene

Research Project

Project/Area Number 22591783
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionAichi Medical University (2011-2012)
National Defense Medical College (2010)

Principal Investigator

SUMITOMO Makoto  愛知医科大学, 医学部, 教授 (50255535)

Co-Investigator(Kenkyū-buntansha) ASANO Tomohiko  防衛医科大学校, 医学教育部医学科専門課程, 教授 (40167226)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsポリエチレングリコール / フラーレン / 癌細胞株 / 収束超音波 / 抗腫瘍効果 / 担癌マウス / ポリエチレングリコール(PEG)
Research Abstract

By chemically modifying fullerene (C60) with polyethylene glycol (PEG), we succeeded in synthesizing water-soluble PEG-conjugated fullerene. MTS assays showed that thecombination of HIFU with PEG-conjugated fullerene resulted in synergistic growth inhibitory effects in PC-3 cells in vitro. In vivo, however, we failed to confirm reproducibility on the results of selective tumor tissue accumulation of fullerene because of instability of labeled PEG-conjugated fullerene. Using chicken tissue model we found synergistic tissue degenerating effects by this combination therapy, which showed no additive or synergistic antitumor effects in PC-3 xenograft models.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Anterior perirectal fat tissue thickness is a strong predictor of recurrence after high-intensity focused ultrasound for prostate cancer.2010

    • Author(s)
      Sumitomo M, et al
    • Journal Title

      Int.J.Urol.

      Volume: 17(9) Pages: 776-782

    • NAID

      10027259845

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transurethral resection of the prostate immediately after high-intensity focused ultrasound treatment for prostate cancer.2010

    • Author(s)
      Sumitomo M, et al
    • Journal Title

      Int.J.Urol.

      Volume: 17(11) Pages: 924-930

    • NAID

      10027730611

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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