Strategy targeting neuropeptide receptors in the central and peripheral nervous systems in treatment of underactive bladder
Project/Area Number |
22591787
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | University of Yamanashi |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NAKAGOMI Hiroshi 山梨大学, 医学部附属病院, 助教 (80418714)
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 排尿障害 / 膀胱 / 尿道 / 糖尿病 / 脳下垂体アデニル酸シクラーゼ活性化ポリペプチド(PACAP) / マウス / 低活動膀胱 / 下部尿路障害 / 脊髄 / 神経ペプチド / 膀胱コンプライアンス / 排尿収縮圧 / 残尿 / 反射排尿 / 尿意切迫感 / 切迫性尿失禁 / 神経障害 / 下部尿路機能 / 外尿道括約筋 / 脊髄損傷 / 末梢神経障害 |
Research Abstract |
Lower urinary tract function of genetically mutated mice with diabetes mellitus (DM) was evaluated and compared to that of the wild-type mice. The results suggest that in DM mice, mechanism controlling voiding in the forebrain is devoid of appropriate inhibitory function, and thus the animals present reflex micturition. DM mice at age of 30 week-old still retain voiding efficiency more than 80%, albeit moderately present underactive bladder. Intrathecal administration of PACAP-38 increased maximal voiding pressure and partially suppressed external urethral sphincter activity, suggesting the possibility that stimulation of spinal PACAP receptors enhancesbladder contractility and ameliorates efficiency for voiding.
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Report
(4 results)
Research Products
(55 results)
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[Presentation] Vesicular nucleotide transporter (VNUT) is a key molecule for mechanosensing in the human urinary bladder: negative correlation between VNUT expression in human bladder mucosa and first desire to void. (Abstract No. 12)2012
Author(s)
Nakagomi H, Mochizuki T, Miyamoto T, Kira S, Yoshiyama M, Kawahara K, Moriyama Y, Koizumi S, Takeda M.
Organizer
International Continence Society 42nd Annual meeting, China National Convention Centre
Place of Presentation
Beijing, China
Related Report
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[Presentation] (vesicular nucleotide transporter) plays a crucial role in stretch-evoked ATP release from urothelium.2012
Author(s)
Nakagomi H, Mochizuki T, Miyamoto T, Yoshiyama M, Araki I, Moriyama Y, Koizumi S, Takeda M.
Organizer
American Urological Association Annual Meeting, Georgia World Congress Center
Place of Presentation
Atlanta, Georgia, U.S.A.
Related Report
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[Presentation] Gene expression patterns of acid-sensing ion channels (ASICs) families in mammalian bladder.2010
Author(s)
Kobayashi H, Yoshiyama M, Inuzuka H, Kira S, Nakagomi H, Miyamoto T, Haneda Y, Sawada N, Zakoji H, Tsuchida T, Araki I, Takeda M.
Organizer
International Continence Society 40th/International Uro-Gynecology Association Joint Meeting
Place of Presentation
Toronto, Canada
Related Report
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[Presentation] Hypertension and type 2 diabetes mellitus are highly associated with nocturia than metabolic syndrome in Japanese population.2010
Author(s)
Imamura N, Nakagomi H, Yoda Y, Zakoji H, Kobayashi H, Tsuchida T, Fukazawa M, Yoshiyama M, Araki I, Takeda M.
Organizer
International Continence Society 40th /International Uro-Gynecology Association Joint Meeting
Place of Presentation
Toronto, Canada
Related Report
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