Survey of chronological changes of azithromycin resistance and analyses of azithromycin resistance mechanisms in clinical strains of Neisserira gonorrhoeae
| Project/Area Number |
22591788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gifu University |
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Principal Investigator |
DEGUCHI Takashi 岐阜大学, 大学院・医学系研究科, 教授 (40163935)
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| Co-Investigator(Kenkyū-buntansha) |
安田 満 岐阜大学, 医学部附属病院, 講師 (90311703)
中根 慶太 岐阜大学, 医学部附属病院, 医員 (00566482)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 感染症学 / 性感染症 / 淋菌 / アジスロマイシン / 薬剤耐性 / 23S rRNA / 23SrRNA |
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| Research Abstract |
Clinical strains of Neisseria gonorrhoeae isolated in 2010, 2011 and 2012 were examined for antimicrobial susceptibility to azithromycin. The MIC50 and MIC90, which were defined as minimum concentrations inhibiting the growth of 50% and 90% of the isolates, were 0.25 μg/ml and 0.5 μg/ml, 0.5 μg/ml and 1 μg/ml, and 0.25 μg/ml and 1 μg/ml for the isolates in 2010, 2011, and 2012, respectively. The 23S rRNA genes in the strains were examined for the presence of azxithromycin resistance-associated mutations. Our current study demonstrated that some clinical strains with intermediate resistance to azithromycin have emerged in Japan and that the resistance was associated with the mutation in the 23S rRNA gene.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] 男子尿道炎2012
Author(s)
出口 隆
Organizer
第60回日本化学療法学会学術総会
Place of Presentation
長崎ブリックホール、長崎
Related Report
Invited
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