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Measurements of Alanine:Glyoxylate transamination and Glyoxylate Reductase for hyperoxaluria

Research Project

Project/Area Number 22591789
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

NAGATA Masao  浜松医科大学, 医学部附属病院, 助教 (70397397)

Co-Investigator(Kenkyū-buntansha) OZONO Seiichiro  浜松医科大学, 医学部附属病院, 教授 (00183228)
TAKAYAMA Tatsuya  浜松医科大学, 医学部附属病院, 講師 (90324350)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords結石症学 / 尿路結石症 / 蓚酸
Research Abstract

The activity of SPT/AGT can be measured by SGT activity also not only in a healthy person but in PH1 patient. The activity of GR can be measured by DGDH activity, in nine stone patients' average was 1.81±0.76 nmol/min/mg protein. L-Glycerate can be measured by HPLC used a chiral column. The comparison of L-Glycerate with 52 non-stone patients (non-stone former:non-SF) and nine stone patients (stone former:SF) , The value of SF was high with non-SF 13.3micromol/L, SF 21.3micromol/L, is a significant difference at the median.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] 各種病態にみられる腎障害 代謝性疾患、電解質異常:高シュウ酸尿症,別冊 日本臨牀 新領域別症候群シリーズ2012

    • Author(s)
      高山達也,永田仁夫,大園誠一郎
    • Journal Title

      No.18 腎臓症候群(第2 版)下-その他の腎臓疾患を含めて

      Volume: 18巻 Pages: 338-341

    • Related Report
      2012 Final Research Report
  • [Journal Article] 有機酸・脂肪酸代謝異常;原発性高シュウ酸尿症II型,別冊日本臨牀 新領域別症候群シリーズ2012

    • Author(s)
      高山達也,永田仁夫,大園誠一郎
    • Journal Title

      No.19 先天代謝異常症候群(第2 版) 上 -病因・病態研究,診断・治療の進歩

      Pages: 488-492

    • Related Report
      2012 Final Research Report
  • [Journal Article] 機酸・脂肪酸代謝異常;原発性高シュウ酸尿症III型,別冊日本臨牀 新領域別症候群シリーズ2012

    • Author(s)
      高山達也,永田仁夫,大園誠一郎
    • Journal Title

      No.19 先天代謝異常症候群(第3 版) 上 -病因・病態研究,診断・治療の進歩

      Pages: 493-496

    • Related Report
      2012 Final Research Report
  • [Journal Article] ペルオキシソーム病 単独酵素欠損症;原発性高シュウ酸尿症I型,別冊日本臨牀新領域別症候群シリーズ2012

    • Author(s)
      高山達也,永田仁夫,大園誠一郎
    • Journal Title

      No.20 先天代謝異常症候群(第2 版)下-病因・病態研究,診断・治療の進歩

      Pages: 450-453

    • Related Report
      2012 Final Research Report
  • [Journal Article] 蓚酸代謝関連酵素に尿路結石治療の未来を求めて2011

    • Author(s)
      高山達也,永田仁夫,麦谷荘一,大園誠一郎
    • Journal Title

      泌尿器科紀要

      Volume: 57巻 1号 Pages: 39-41

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] カルシウム代謝と尿路結石 ; カルシウム結石予防のための薬物療法2011

    • Author(s)
      永田仁夫,高山達也,麦谷荘一,大園誠一朗
    • Journal Title

      CLINICAL CALCIUM

      Volume: 21巻 10号 Pages: 102-106

    • Related Report
      2012 Final Research Report
  • [Journal Article] SGT 活性によるAGT 測定系の確立2010

    • Author(s)
      永田仁夫,高山達也,麦谷荘一,小田敏明,市山 新,大園誠一郎
    • Journal Title

      日本尿路結石症学会誌

      Volume: 9巻 2号 Pages: 105-109

    • Related Report
      2012 Final Research Report
  • [Presentation] Ethnic differences in GRHPR gene mutation in primary hyperoxaluria type 22012

    • Author(s)
      Takayama T, Takaoka N, Nagata M, Johnin K, Okada Y, Kuhara T, Rumsby G, Cramer SD, Ozono S
    • Organizer
      10th International primary hyperoxaluria workshop
    • Place of Presentation
      Bonn, Germany
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] PH1 can be also diagnosed by measuring SGT activity2012

    • Author(s)
      Nagata M, Ichiyama A, Takayama T, Mugiya S, Ozono S
    • Organizer
      10th International primary hyperoxaluria workshop
    • Place of Presentation
      Bonn, Germany
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] SGT 活性による原発性高蓚酸尿症 1 型の診断2011

    • Author(s)
      永田仁夫,高山達也,鈴木孝尚,松本力哉,伊藤寿樹,杉山貴之,大塚篤史,古瀬 洋,麦谷荘一,大園誠一郎
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] SGT 活性による AGT 測定系の確立2010

    • Author(s)
      永田仁夫,高山達也,麦谷荘一,小田敏明,市山 新,大園誠一郎
    • Organizer
      第20回日本尿路結石症学会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-08-27
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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