| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
α2-adrenoceptor (AR) agonists and antagonists additionally have varying affinity for imidazoline receptors (I-Rs). It has been reported that intrathecal (i.t.) administration of α2-AR agonists such as dexmedetomidine induces the sedative and analgesic effects and that i.t. application of I1-R agonists such as clonidine has the hypotensive effect. In this study, we investigated the role of spinal α2-ARs, I1-Rs and I2-Rs in the control of voiding and continence reflexes in rats.
The results of our study suggest that sensory transduction from the bladder (represented by threshold pressure changes) are in part mediated by α2-ARs in the spinal cord and that urethral smooth and/or striated muscle sphincter (represented by leak point pressue changes) are partly controlled by spinal I1-Rs. These findings would be useful to develop the new treatments for lower urinary tract dysfunction.
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