A basic study on the effects of fetal circulation have on the placenta oxygenation dynamics by near-infrared spectroscopy
| Project/Area Number |
22591820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SUZUKI Kazunao 浜松医科大学, 医学部附属病院, 講師 (50456571)
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| Co-Investigator(Kenkyū-buntansha) |
KANAYAMA Naohiro 浜松医科大学, 医学部, 教授 (70204550)
ITOH Hiroaki 浜松医科大学, 医学部附属病院, 准教授 (70263085)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 産科学 / 胎盤酸素濃度 / 臍帯血流 / 近赤外線分光法 / 胎盤 / 酸素 / 子宮内胎児発育不全 / 妊娠高血圧症候群 |
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| Research Abstract |
We recently found a significant elevation in placental tissue oxygen index (TOI) values in cases of fetal growth restriction using near-infrared spectroscopy (NIRS), indicating high oxygenation in the placental tissue. We hypothesized that insufficient fetoumbilical blood flow is causatively associated with high oxygenation levels in placental tissue. We transiently (for 15 sec) ligated the whole umbilicus, umbilical arteries, or veins of pregnant Clawn miniature pigs (102-113 days of gestation) and assessed the changes in TOI values of the placenta and fetus. The ligation significantly increased placental TOI values (p
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Association Between Body Weight at Weaning and Remodeling in the Subcutaneous Adipose Tissue of Obese Adult Mice With Undernourishment In Utero.2013
Author(s)
Kohmura YK, Kanayama N, Muramatsu K, Tamura N, Yaguchi C, Uchida T, Suzuki K, Sugihara K, Aoe S, Sasaki T, Suganami T, Ogawa Y, Itoh H.
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Journal Title
Related Report
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[Journal Article] Transient ligation of umbilical vessels elevates placental tissue oxygen index (TOI) values measured by near-infrared spectroscopy (NIRS) in clawn miniature pig animal model.2012
Author(s)
Suzuki K, Itoh H, Muramatsu K, Yamazaki K, Nagahashi K, Furuta N, Tamura N, Uchida T, Sugihara K, Sumimoto K, Kanayama N
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Journal Title
Clin Exp Obstet Gynecol
Volume: 39(3)
Pages: 293-8
Related Report
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[Journal Article] Immunohistochemical detection of meconium in the fetal membrane2012
Author(s)
Furuta N, Yaguchi C, Itoh H, Morishima Y, Tamura N, Kato M, Uchida T, Suzuki K, Sugihara K, Kawabata Y, Suzuki N, Sasaki T, Horiuchi K, Kanayama N
Volume
33(1)
Pages
24-30
Related Report
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[Journal Article] 母獣低換気による高二酸化炭素血症は臍帯血流遮断時の胎仔に保護的に作用する 近赤外線分光法を用いた動物実験による検討2012
Author(s)
鈴木 一有, 下山 華, 村松 慧子, 山崎 香織, 長橋 ことみ, 幸村 友季子, 柴田 俊章, 内田 季之, 杉原 一廣, 伊東 宏晃, 住本 和博, 金山 尚裕
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Journal Title
日本産科婦人科学会雑誌(0300-9165)
Volume: 64巻 2号
Pages: 564-564
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[Journal Article] Reduction in Levels of Maternal Cmplement during Delivery by Cesarean2011
Author(s)
Kato M, Itoh H, Nagahashi K, Izima M, Hirai K, Tamura M, Uchida T, Yaguchi C, Suzuki K, Sugihara K, Kanayama K.
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Journal Title
J Obstet Gynaecol Res
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Case of polyhydramnios complicated by Opitz G/BBB syndrome2010
Author(s)
Tajima H, Itoh H, Mochizuki A, Nakamura Y, Kobayashi Y, Hirai K, Suzuki K, Sugihara K, Ohishi A, Ohzeki T, Kanayama N
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Journal Title
J Obstet Gynaecol Res
Volume: 36
Pages: 876-881
NAID
Related Report
Peer Reviewed
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