• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A basic study on the effects of fetal circulation have on the placenta oxygenation dynamics by near-infrared spectroscopy

Research Project

Project/Area Number 22591820
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

SUZUKI Kazunao  浜松医科大学, 医学部附属病院, 講師 (50456571)

Co-Investigator(Kenkyū-buntansha) KANAYAMA Naohiro  浜松医科大学, 医学部, 教授 (70204550)
ITOH Hiroaki  浜松医科大学, 医学部附属病院, 准教授 (70263085)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords産科学 / 胎盤酸素濃度 / 臍帯血流 / 近赤外線分光法 / 胎盤 / 酸素 / 子宮内胎児発育不全 / 妊娠高血圧症候群
Research Abstract

We recently found a significant elevation in placental tissue oxygen index (TOI) values in cases of fetal growth restriction using near-infrared spectroscopy (NIRS), indicating high oxygenation in the placental tissue. We hypothesized that insufficient fetoumbilical blood flow is causatively associated with high oxygenation levels in placental tissue. We transiently (for 15 sec) ligated the whole umbilicus, umbilical arteries, or veins of pregnant Clawn miniature pigs (102-113 days of gestation) and assessed the changes in TOI values of the placenta and fetus. The ligation significantly increased placental TOI values (p

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (38 results)

All 2013 2012 2011 2010

All Journal Article (22 results) (of which Peer Reviewed: 11 results) Presentation (16 results)

  • [Journal Article] Cerebral oxygen saturation evaluated by near-infrared time-resolved spectroscopy (TRS) in pregnant women during caesarean section - a promising new method of maternal monitoring.2013

    • Author(s)
      Yamazaki K, Suzuki K, Itoh H, Muramatsu K, Nagahashi K, Tamura N, Uchida T, Sugihara K, Maeda H, Kanayama N.
    • Journal Title

      Clin Physiol Funct Imaging

      Volume: 33(2) Pages: 109-16

    • Related Report
      2012 Final Research Report
  • [Journal Article] Association Between Body Weight at Weaning and Remodeling in the Subcutaneous Adipose Tissue of Obese Adult Mice With Undernourishment In Utero.2013

    • Author(s)
      Kohmura YK, Kanayama N, Muramatsu K, Tamura N, Yaguchi C, Uchida T, Suzuki K, Sugihara K, Aoe S, Sasaki T, Suganami T, Ogawa Y, Itoh H.
    • Journal Title

      Reprod Sci

    • Related Report
      2012 Final Research Report
  • [Journal Article] Transient ligation of umbilical vessels elevates placental tissue oxygen index (TOI) values measured by near-infrared spectroscopy (NIRS) in clawn miniature pig animal model.2012

    • Author(s)
      Suzuki K, Itoh H, Muramatsu K, Yamazaki K, Nagahashi K, Furuta N, Tamura N, Uchida T, Sugihara K, Sumimoto K, Kanayama N
    • Journal Title

      Clin Exp Obstet Gynecol

      Volume: 39(3) Pages: 293-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Successful living donor liver transplantation for fulminant hepatic failure that manifested immediately after cesarean delivery2012

    • Author(s)
      Horikoshi Y, Itoh H, Kikuchi S, Uchida T, Suzuki K, Sugihara K, Kanayama N, Mori A, Uemoto S.
    • Journal Title

      ASAIO J

      Volume: 58(2) Pages: 174-6

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reduction in maternal complement levels during delivery by cesarean section.2012

    • Author(s)
      Kato M, Itoh H, Nagahashi K, Izima M, Yaguchi C, Uchida T, Suzuki K, Sugihara K, Kanayama N
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 38(1) Pages: 165-71

    • Related Report
      2012 Final Research Report
  • [Journal Article] Immunohistochemical detection of meconium in the fetal membrane2012

    • Author(s)
      Furuta N, Yaguchi C, Itoh H, Morishima Y, Tamura N, Kato M, Uchida T, Suzuki K, Sugihara K, Kawabata Y, Suzuki N, Sasaki T, Horiuchi K, Kanayama N
    • Volume
      33(1)
    • Pages
      24-30
    • Related Report
      2012 Final Research Report
  • [Journal Article] 母獣低換気による高二酸化炭素血症は臍帯血流遮断時の胎仔に保護的に作用する 近赤外線分光法を用いた動物実験による検討2012

    • Author(s)
      鈴木 一有, 下山 華, 村松 慧子, 山崎 香織, 長橋 ことみ, 幸村 友季子, 柴田 俊章, 内田 季之, 杉原 一廣, 伊東 宏晃, 住本 和博, 金山 尚裕
    • Journal Title

      日本産科婦人科学会雑誌(0300-9165)

      Volume: 64巻 2号 Pages: 564-564

    • Related Report
      2012 Final Research Report
  • [Journal Article] 帝王切開中の新しい術中脳酸素モニタリング法2012

    • Author(s)
      山崎 香織, 鈴木 一有, 村松 慧子, 長橋 ことみ, 伊東 宏晃, 住本 和博, 金山 尚裕
    • Journal Title

      日本周産期・新生児医学会雑誌(1348-964X)

      Volume: 48巻 2号 Pages: 579-579

    • Related Report
      2012 Final Research Report
  • [Journal Article] Transient ligation of umbilical vessels elevates placental tissue oxygen index(TOI) values measure by near-infrared spectroscopy(NIRS) in clawn miniature pig animal model2012

    • Author(s)
      Kazunao Suzuki
    • Journal Title

      Clin.Exp.Obstet.& Gyn.

      Volume: 39 Pages: 293-298

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral oxygen saturation evaluated by near-infrared time-resolved spectroscopy (TRS) in pregnant women during caesarean section - a promising new method of maternal monitoring2012

    • Author(s)
      Kaori Yamazaki
    • Journal Title

      Clin Physiol Funct Imaging

      Volume: 32 Issue: 2 Pages: 109-116

    • DOI

      10.1111/cpf.12001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical detection of meconium in the fetal membrane, placenta and umbilical cord2012

    • Author(s)
      Naomi Fruta
    • Journal Title

      Placenta

      Volume: 33 Issue: 1 Pages: 24-30

    • DOI

      10.1016/j.placenta.2011.10.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of spontaneous rupture of a uterine superficial varicose vein in midgestation2011

    • Author(s)
      Nakaya Y, Itoh H, Muramatsu K, Otome M, Kobayashi Y, Hirai K, Uchida T, Suzuki K, Sugihara K, Kanayama N.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37(8) Pages: 1149-53

    • Related Report
      2012 Final Research Report
  • [Journal Article] A rapid activated protein C sensitivity test as a diagnostic marker for a suspected venous thromboembolism in pregnancy and puerperium2011

    • Author(s)
      Hirai K, Sugimura M, Ohashi R, Suzuki K, Itoh H, Sugihara K, Kanayama N.
    • Journal Title

      Gynecol Obstet Invest

      Volume: 72(1) Pages: 55-62

    • Related Report
      2012 Final Research Report
  • [Journal Article] 近赤外時間分解分光法を用いた新しい妊婦脳循環モニタリング2011

    • Author(s)
      鈴木一有, 山崎香織, 加茂亜希, 平井久也, 加藤誠, 内田季之, 伊東宏晃, 金山尚裕
    • Journal Title

      日本周産期・新生児医学会雑誌(1348-964X)

      Volume: 47巻 2号 Pages: 388-388

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reduction in Levels of Maternal Cmplement during Delivery by Cesarean2011

    • Author(s)
      Kato M, Itoh H, Nagahashi K, Izima M, Hirai K, Tamura M, Uchida T, Yaguchi C, Suzuki K, Sugihara K, Kanayama K.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of spontaneous rupture of a uterine superficial varicose vein in midgestatio2011

    • Author(s)
      Nakaya Y, Itoh H, Muramatsu K, Otome M, Kobayashi Y, Hirai K, Uchida T, Suzuki K, Dugihara K, Kanayama N
    • Journal Title

      J Obstet Gynaecol Res

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rapid activated protein C sensitivity test as a diagnostic marker for a suspected venous thromboembolism in pregnancy and puerperium2011

    • Author(s)
      Hirai K, Sugimura M, Ohashi R, Suzuki K, Itoh H, Sugihara K, Kanavama N.
    • Journal Title

      Gynecol Obstet Invest

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 近赤外時間分解分光法を用いた妊婦脳循環モニタリング2010

    • Author(s)
      鈴木一有、平井久也、内田季之、伊東宏晃、金山尚裕、大前悦子
    • Journal Title

      日本妊娠高血圧学会雑誌

      Volume: 18 Pages: 153-154

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of polyhydramnios complicated by Opitz G/BBB syndrome2010

    • Author(s)
      Tajima H, Itoh H, Mochizuki A, Nakamura Y, Kobayashi Y, Hirai K, Suzuki K, Sugihara K, Ohishi A, Ohzeki T, Kanayama N
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 36 Pages: 876-881

    • NAID

      10031121711

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc and magnesium ions synergistically inhibit superoxide generation by cultured human neutrophils--a promising candidate formulation for amnioinfusion fluid2010

    • Author(s)
      Uchida T, Itoh H, Nakamura Y, Kobayashi Y, Hirai K, Suzuki K, Sugihara K, Kanayama N, Hiramatsu M
    • Journal Title

      J Reprod Immunol

      Volume: 85 Pages: 209-213

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of a huge placental lake ; prenatal differential diagnosis and clinical management2010

    • Author(s)
      Muramatsu K, Itoh H, Yamasaki T, Nakamura Y, Kobayashi Y, Hirai K, Suzuki K, Sugihara K, Sugimura M, Kanayama N
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 36 Pages: 165-169

    • NAID

      10031121590

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 母体に糖尿病性ネフローゼ症候群を合併し子宮内胎児死亡となり、癒着胎盤のため子宮全摘となった1例2010

    • Author(s)
      乙洋雅子、内田季之、田島浩子、矢田大輔、望月亜矢子、小林友季子、中村友紀、平井久也、谷口千津子、鈴木一有、杉原一廣、伊東宏晃、有澤正義、金山尚裕
    • Journal Title

      日産婦関東連合会誌

      Volume: 47 Pages: 431-435

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 母獣の高炭酸ガス血症は胎仔に保護的に作用するー近赤外線分光法を用いた動物実験による検討ー2013

    • Author(s)
      鈴木一有
    • Organizer
      第65回日本産科婦人科学会総会学術講演会
    • Place of Presentation
      北海道札幌市
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム発表胎児の発育異常の取り扱い」近赤外線分光法によるFGR合併妊婦の胎盤評価2012

    • Organizer
      第36回日本産科婦人科栄養・代謝研究会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム発表妊娠高血圧症候群と母体画像所見」近赤外線分光法を用いた妊婦脳循環モニタリ2012

    • Organizer
      第33回日本妊娠高血圧学会
    • Place of Presentation
      長崎県長崎市
    • Related Report
      2012 Final Research Report
  • [Presentation] 母獣低換気による高二酸化炭素血症は臍帯血流遮断時の胎仔に保護的に作用する 近赤外線分光法を用いた動物実験による検討2012

    • Author(s)
      鈴木一有
    • Organizer
      第64回日本産科婦人科学会総会学術講演会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 近赤外線分光法によるFGR合併妊婦の胎盤評価2012

    • Author(s)
      鈴木一有
    • Organizer
      第36回日本産科婦人科栄養・代謝研究会
    • Place of Presentation
      鹿児島県鹿児島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 近赤外線分光法を用いた妊婦脳循環モニタリング2012

    • Author(s)
      鈴木一有
    • Organizer
      第33回日本妊娠高血圧学会
    • Place of Presentation
      長崎県長崎市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 近赤外時間分解分光法を用いた新しい妊婦脳循環モニタリング2011

    • Author(s)
      鈴木一有
    • Organizer
      日本周産期・新生児医学会総会学術講演会
    • Place of Presentation
      札幌市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新しい非侵襲的かつ持続的な妊婦脳循環モニタリング法2011

    • Author(s)
      鈴木一有
    • Organizer
      日本産科婦人科学会総会学術講演会
    • Place of Presentation
      大阪市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 妊娠高血圧症候群合併妊婦の新しい脳循環モニタリング2010

    • Author(s)
      鈴木一有
    • Organizer
      第31回日本妊娠高血圧学会
    • Place of Presentation
      東京都
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臍帯血流の胎盤酸素化指標への影響 妊娠ミニ豚による基礎的検討2010

    • Author(s)
      鈴木一有
    • Organizer
      第18回日本胎盤学会学術集会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新しい非侵襲的かつ持続的な妊婦脳循環モニタリング法2010

    • Author(s)
      鈴木一有
    • Organizer
      第33回日本母体胎児医学会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎盤酸素濃度に対する臍帯血流の影響 近赤外線分光法による基礎的検討2010

    • Author(s)
      鈴木一有
    • Organizer
      日本周産期・新生児医学会総会 学術講演会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臍帯血流の胎盤組織酸素化指標への影響 妊娠ミニ豚による基礎的検討2010

    • Author(s)
      鈴木一有
    • Organizer
      日本産科婦人科学会総会 学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臍帯血流の胎盤組織酸素化指標への影響 妊娠ミニ豚による基礎的検討 日本産科婦人科学会総会 学術2010

    • Organizer
      日本産科婦人科学会総会 学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 胎盤酸素濃度に対する臍帯血流の影響 近赤外線分光法による基礎的検討2010

    • Organizer
      日本周産期・新生児医学会総会学術講演会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Final Research Report
  • [Presentation] 新しい非侵襲的かつ持続的な妊婦脳循環モニタリング法2010

    • Organizer
      第33回日本母体胎児医学会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-11-30   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi