| Project/Area Number |
22591822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
KAKUI Kazuyo 京都大学, 医学研究科, 非常勤講師 (40531067)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Keiji 京都大学, 医学研究科, 非常勤講師 (10324633)
KONDO Eiji 京都大学, 医学研究科, 助教 (10544950)
KONISHI Ikuo 京都大学, 医学研究科, 教授 (90192062)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 卵膜 / 成長因子 / 妊娠高血圧症候群 / 胎児発育遅延 / クロストーク / 産婦人科 / 早産 / 羊膜 |
|---|
| Research Abstract |
First, we found that receptors of nerve growth factors, such as neurotrophin, were expressed in amnion, which suggested that these nerve growth factors had some roles in the signal transduction between mother and fetus. Secondaly, in primary amnion mesenchymal cells, increase of matrix metalloprotenases and cyclooxygenase type-2 by fetal fibronectin were significantly suppressed by tranexamic acid, which implied that tranexamic acid might be useful for prevention or treatment of preterm rupture of membrane and preterm birth.
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