Molecular mechanisms of crosstalk between fetus and mother via fetal membrane

• Project/Area Number: 22591822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: KAKUI Kazuyo 京都大学, 医学研究科, 非常勤講師 (40531067)
• Co-Investigator(Kenkyū-buntansha): TATSUMI Keiji 京都大学, 医学研究科, 非常勤講師 (10324633) ; KONDO Eiji 京都大学, 医学研究科, 助教 (10544950) ; KONISHI Ikuo 京都大学, 医学研究科, 教授 (90192062)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 卵膜 / 成長因子 / 妊娠高血圧症候群 / 胎児発育遅延 / クロストーク / 産婦人科 / 早産 / 羊膜

Research Abstract

First, we found that receptors of nerve growth factors, such as neurotrophin, were expressed in amnion, which suggested that these nerve growth factors had some roles in the signal transduction between mother and fetus. Secondaly, in primary amnion mesenchymal cells, increase of matrix metalloprotenases and cyclooxygenase type-2 by fetal fibronectin were significantly suppressed by tranexamic acid, which implied that tranexamic acid might be useful for prevention or treatment of preterm rupture of membrane and preterm birth.

Research Products

• [Journal Article] Differential expression and the anti-apoptotic effect of human placental neurotrophins and their receptors (2011)
  • Author(s): Fujita K., et al
  • Journal Title: Placenta Volume: 32 Issue: 10 Pages: 737-744
  • DOI: 10.1016/j.placenta.2011.07.001
  • Peer Reviewed
• [Journal Article] Branched-chain amino acid supplemented diet during maternal food restriction prevents developmental hypertension in adult rat offspring (2011)
  • Author(s): Fujii T, Yura S, Tatsumi K, Kondoh E, Mogami H, Fujita K, Kakui K, Aoe S, Ito H, Sagawa N, Fujii S, Konishi I
  • Journal Title: Journal of Developmental Origins of Health and Disease Volume: 2 Pages: 176-183
  • URL: http://dx.doi.org/10.1017/S204017441100002X
  • Peer Reviewed
• [Journal Article] Thioredoxin binding protein-2 inhibits excessive fetal hypoglycemia during maternal starvation by suppressing insulin secretion in mice (2010)
  • Author(s): Mogami H, Yura S, Tatsumi K, Fujii T, Fujita K, Kakui K, Kondoh E, Inoue T, Fujii S, Yodoi J, Konishi I
  • Journal Title: Pediatr Res Volume: 67 Issue: 2 Pages: 138-43
  • DOI: 10.1203/pdr.0b013e3181c2f4cc
  • Peer Reviewed
• [Journal Article] 妊娠高血圧症候群の病態解明 -分子機構を中心に - 9 (2010)
  • Author(s): 巽啓司、藤田浩平、近藤英治、角井和代、小西郁生
  • Journal Title: 神経栄養因子から見た妊娠高血圧症候群、産婦人科の実際 Volume: 59 Pages: 1057-1061
• [Presentation] ヒト胎盤における神経栄養因子と酸化ストレスの関係 (2011)
  • Author(s): 藤田浩平、他
  • Organizer: 第63回日本産科婦人科学会 学術講演会
  • Place of Presentation: 大阪
• [Presentation] ヒト胎盤における神経栄養因子および受容体の発現と胎児発育や胎内環境との関係 (2010)
  • Author(s): 藤田浩平、他
  • Organizer: 第62回日本産科婦人科学会 学術講演会
  • Place of Presentation: 東京