Genome-wide DNA methylation profile analysis relating pathogenesisof endometriosis
| Project/Area Number |
22591825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹谷 俊明 山口大学, 医学部附属病院, 助教 (70464328)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮内膜症 / DNA メチル化 / DNAメチル化 |
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| Research Abstract |
Genome-wide DNA methylation analysis identified numerous aberrant hypermethylated and hypomethylated CpGs present in endometrial stromal cells from chocolate cyst. Taken together with the result of transcriptome, some sets of genes are associated with pathogenesis of endometriosis. Principal component analysis indicated different DNA methylation profile in chocolate cyst cells, whereas transciptome could not. These findings imply the significance of genome wide DNA methylation analysis rather than transcriptome analysis to clarify development and characterization of endometriosis.
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Report
(4 results)
Research Products
(18 results)
