| Project/Area Number |
22591829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Oita University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARAHARA Hisashi 大分大学, 医学部, 教授 (60211447)
NASU Kaei 大分大学, 医学部, 教授 (30274757)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
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| Keywords | 子宮内膜 / アディポサイトカイン / 着床 |
|---|
| Research Abstract |
Our objective was to clarify the effect of AMPK on production of chemokines and prostaglandins by human endometrial stromal cells (ESCs). The phosphorylations of AMPK were observed by treatment with AICAR. Moreover, IL-1-stimulated chemokines and PG production was decreased by a mechanism involving AMPK. AMPK may play an important role in the anti-inflammatory effect resulting to reduction of chemokines and PG production, which may contribute to the modulation of a local factor in human endometrium.
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