Application of Fetal Adenosine Activity in the Development of a New Drug-Eluting Stent
| Project/Area Number |
22591838
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SAWA Rintaro 日本医科大学, 医学部, 講師 (30267174)
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| Co-Investigator(Kenkyū-buntansha) |
MINE Katsuya 日本医科大学, 医学部, 助教 (60409216)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アデノシン / 薬物溶出性ステント(DES) / 再狭窄 / 羊胎児慢性実験モデル胎児血管 / A1 受容体 / A3 受容体 / 2-chloroadenosine(2CA) / 薬剤溶出性ステント / 胎児血管 / 2-chloroadenosine / アデノシン受容体 / ステント内再狭窄 / 次世代DES / 羊胎児慢性実験 / ステント内再狭窄率 / DES / 羊胎仔慢性実験モデル / 胎児結管 / アデノシンA1受容体 / アデノシンA2受容体 / アデノシンA3受容体 / in-stent-thrombosis |
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| Research Abstract |
The aim of this research was to evaluate whether local delivery of adenosine improves reendotheliazation and decrease inflammation after artery stenting in the fetal sheep. Our data demonstrate the potential of local adenosine administration to improve vascular herling and prevent in-stent restenosis via both A1 and A3 adenosinereceptors, may lead to the development of a new DES device.
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Report
(4 results)
Research Products
(6 results)
