| Project/Area Number |
22591839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ITOH Masanori 東京医科歯科大学, 教養部, 教授 (30257349)
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| Project Period (FY) |
2010-10-20 – 2013-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | メラトニン / セロトニン / 卵巣 / 卵母細胞 / ラット / メラトニン合成酵素 |
|---|
| Research Abstract |
Melatonin is originally identified in the pineal gland, where it is synthesized enzymatically from serotonin by the sequential action of arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT). Our data revealed that AANAT and ASMT are expressed in the adult rat ovary. like the pineal gland. AANAT protein is localized to the oocyte, corpus luteum, and medulla including mast cells. AANAT protein was found in oocytes at all stages of follicular development, and its levels in oocytes increased progressively throughout the follicular development. Furthermore, we showed that melatonin is synthesized from serotonin in oocytes. Melatonin synthesized in the oocyte may be implicated in its own growth and/or maturation, for example, by acting as a calmodulin antagonist and/or an antioxidant.
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