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New Biomarkers for Lymph Node Metastasis in Patients with EndometrialCancer using Exon-expression Microarray

Research Project

Project/Area Number 22591843
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionHokkaido University

Principal Investigator

SUDO Satoko  北海道大学, 北海道大学病院, 助教 (10399892)

Co-Investigator(Kenkyū-buntansha) SAKURAGI Noriaki  北海道大学, 大学院・医学研究科, 教授 (70153963)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords婦人科腫瘍学 / biomarker / endometrial cancer / lymph node metastasis / ANKRD36 / CROP / MALAT-1 / 子宮体癌 / バイオマーカー / リンパ節転移
Research Abstract

To predict lymph node metastasis using primary cancer tissue preoperatively, we explored putative biomarker genes of node metastasis in patients with endometrial cancer. Three up-regulated transcripts in node-positive group were picked up; ANKRD36 (ankyrin repeat domain containing 36), CROP and MALAT-1. mmunostaining analyses elucidated that ANKRD36 and CROP are localized in cytoplasm and nuclei of cancer cells, respectively. Furthermore, in node-positive group, ANKRD36 protein expression levels weresignificantly high compared with one in node-negative group. In situ hybridization showedMALAT-1 was localized in nucleus of carcinoma cells. Further analyses will be performed to clarify biological function of these 3 molecules which might be the putative node-positive biomarkers in endometrial cancer.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2013 2011 2010

All Presentation (10 results)

  • [Presentation] Biomarkers for Lymph Node Metastasis in Patients with Endometrial Cancer using Exon-expression Microarray2013

    • Author(s)
      Satoko Sudo, et al
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2013-05-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Exploration of Biomarkers for Lymph Node Metastasis in Patients with Endometrial Cancer using Exon-expression Microarray2013

    • Author(s)
      SATOKO SUDO
    • Organizer
      第65回日本産科婦人科学会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exploration of Biomarkers for Lymph Node Metastasis in Patients with Endometrial Cancer using Exon-expression Microarray2011

    • Author(s)
      Satoko Sudo, et al
    • Organizer
      17th International Meeting of the European Society of Gynaecological Oncology
    • Place of Presentation
      ミラノコ ンベンションセンター(イタリア)
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Exon-expression Microarrayをもちいた子宮体癌リンパ節転移バイオマーカーの探索2011

    • Author(s)
      首藤聡子
    • Organizer
      第50回日本婦人科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Exon-expression Microarrayをもちいた子宮体癌リンパ節転移バイオマーカーの探索2011

    • Author(s)
      首藤聡子
    • Organizer
      第50回日本婦人科腫瘍学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Exploration of Biomarkers for Lymph Node Metastasis in Patients with Endometrial Cancer using Exon-expression Microarray2011

    • Author(s)
      Satoko Sudo, et al
    • Organizer
      2011 ASCO
    • Place of Presentation
      MCCORMICK PLACE(米国)
    • Year and Date
      2011-06-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Exploration of Biomarkers for Lymph Node Metastasis in Patients with Endometrial Cancer using Exon-expression Microarray2011

    • Author(s)
      Satoko Sudo
    • Organizer
      2011 ASCO
    • Place of Presentation
      McCormick Place (USA)
    • Year and Date
      2011-06-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌リンパ節転移バイオマーカーの探索2011

    • Author(s)
      首藤聡子
    • Organizer
      第63回日本産科婦人科学会
    • Place of Presentation
      リーガロイヤルホテル(大阪)
    • Year and Date
      2011-04-16
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Exploration of Biomarkers for Lymph Node Metastasis in Patients with Endometrial Cancer using Exon-expression Microarray2010

    • Author(s)
      Satoko Sudo, et al
    • Organizer
      13th Biennial Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      プラハコングレスセンター(チェコ共和国)
    • Year and Date
      2010-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Exploration of Biomarkers for Lymph Node Metastasis in Patients with Endometrial Cancer using Exon-expression Microarray2010

    • Author(s)
      首藤聡子
    • Organizer
      13th Biennial Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      プラハ、チェコ共和国
    • Year and Date
      2010-10-25
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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