Construction of xenograft models of human endometrial cancer in NOD/SCID IL-2R gamma null mice

• Project/Area Number: 22591847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: 公益財団法人がん研究会 (2012); Chiba University (2010-2011)
• Principal Investigator: KATO Kazuyoshi 公益財団法人がん研究会, 有明病院婦人科, 医長 (80399451)
• Co-Investigator(Kenkyū-buntansha): SHOZU Makio 千葉大学, 医学研究科(研究院), 教授 (30226302) ; MITSUHASHI Akira 千葉大学, 医学研究科(研究院), 准教授 (40302541) ; ISHIKAWA Hiroshi 千葉大学, 医学研究科(研究院), 助教 (70553973)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 子宮内膜癌 / エストロゲン / 腎被膜下移植 / NOGマウス / 動物実験モデル

Research Abstract

We established the procedure of creating the xenograft models of human leiomyoa tissue in NOD/SCID IL-2R gamma null (NOG) mice. However, we could not reconstruct human endometrial cancer under the renal capsule of NOG mice

Research Products

• [Journal Article] Bladder function after modified posterior exenteration for primary gynecological cancer (2013)
  • Author(s): Kazuyoshi Kato, Shinichi Tate, Kyoko Nishikimi, Makio Shozu
  • Journal Title: Gynecol Oncol Volume: 129 Issue: 1 Pages: 229-233
  • DOI: 10.1016/j.ygyno.2013.01.013
  • Peer Reviewed
• [Journal Article] Secondary debulking surgery in ovarian cancer patients with isolated nodal recurrence located in the region above and behind the renal vein (2013)
  • Author(s): Kazuyoshi Kato, Kohei Omatsu, Nobuhiro Takeshima
  • Journal Title: Gynecol Oncol Volume: 2 Issue: 1 Pages: 226-228
  • DOI: 10.1016/j.ygyno.2013.03.025
  • Peer Reviewed
• [Journal Article] Daily Low-Dose Cisplatin-Based Concurrent Chemoradiotherapy in Patients With Uterine Cervical Cancer With Emphasis on Elderly Patients: A Phase 2 Trial (2012)
  • Author(s): Mitsuhashi A, Uno T, Usui H, Nishikimi K, Yamamoto N, Watanabe M, Tate S, Hirashiki K, Kato K, Yamazawa K, Shozu M
  • Journal Title: Int J Gynecol Cancer
  • Peer Reviewed
• [Journal Article] The application of a newly developed linear stapler preloaded with the tissue reinforcement to distal pancreatectomy in the management of ovarian cancer (2011)
  • Author(s): Kazuyoshi Kato, Shinichi Tate, Takashi Uehara, Hirokazu Usui, Akira Mitsuhashi, Makio Shozu
  • Journal Title: Eur J Gynaecol Oncol Volume: 32 Pages: 579-581
  • Peer Reviewed
• [Journal Article] The application of a newly developed linear stapler preloaded with the tissue reinforcement to distal pancreatectomy in the management of ovarian cancer (2011)
  • Author(s): Kazuyoshi Kato, Shinichi Tate, Takashi Uehara, Hirokazu Usui, Akira Mitsuhashi, Makio Shozu
  • Journal Title: European Journal of Gynaecological Oncology Volume: 32 Pages: 579-581
  • Peer Reviewed
• [Journal Article] Postoperative concurrent daily low-dose cisplatin-based chemoradiation improves the prognosis of patients with pathologic T2b or N1 cervical cancer (2010)
  • Author(s): Mitsuhashi A, Uno T, Usui H, Tate S, Hirashiki K, Kato K, Kiyohara H, Kato S, Ito H, Shozu M
  • Journal Title: Anticancer Res Volume: 30 Pages: 2341-6
  • Peer Reviewed
• [Presentation] 症例検討パネルディスカッション06 「再発卵巣がんに対する集学的治療 傍大動脈リンパ節郭清の有効性を含めて」 (2012)
  • Author(s): 加藤一喜
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] "SURGICAL ANATOMY OF THE COMMON ILIAC VEINS IN PARA-AORTIC LYMPHADENECTOMY IN GYNECOLOGICAL CANCER" (2012)
  • Author(s): Kazuyoshi Kato
  • Organizer: The International Gynecologic Cancer Society (IGCS) 14th Biennial Meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] 「卵巣癌の骨盤部主病巣に対する根治術 -腹膜ごと摘出」 (2012)
  • Author(s): 加藤一喜
  • Organizer: 第35回日本産婦人科手術学会 要望講演 「卵巣癌患者の予後とQOL向上を目指して」
  • Place of Presentation: 京都府京都市
• [Presentation] 「進行卵巣癌に対する完全切除を目指した手術療法の有効性と安全性の検討」 (2012)
  • Author(s): 加藤一喜
  • Organizer: 第52回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 東京都港区
• [Presentation] 進行卵巣癌に対する完全切除を目指した手術療法の有効性と安全性の検討 (2012)
  • Author(s): 加藤 一喜
  • Organizer: 第52回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 東京都港区
• [Presentation] 卵巣癌の骨盤部主病巣に対する根治術 -腹膜ごと摘出 (2012)
  • Author(s): 加藤 一喜
  • Organizer: 第35回日本産婦人科手術学会
  • Place of Presentation: 京都府京都市
• [Presentation] 再発卵巣がんに対する集学的治療 傍大動脈リンパ節郭清の有効性を含めて (2012)
  • Author(s): 加藤 一喜
  • Organizer: 第50回日本癌治療学会学術集会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] SURGICAL ANATOMY OF THE COMMON ILIAC VEINS IN PARA-AORTIC LYMPHADENECTOMY IN GYNECOLOGICAL CANCER (2012)
  • Author(s): Kazuyoshi Kato
  • Organizer: The International Gynecologic Cancer Society 14th Biennial Meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] SURGICAL ANATOMY OF THE VAGINAL AND INFERIOR VESICAL ARTERIES IN NERVE-SPARING RADICAL HYSTERECTOMY (2011)
  • Author(s): Kazuyoshi Kato, K.Nishikimi, H.Usui, S.Tate, N.Yamamoto, K.Yamazawa, Akira Mitsuhashi, Makio Shozu
  • Organizer: 17th International Meeting Of The European Society Of Gynaecological Oncology
  • Place of Presentation: Milan Convention Center(イタリア ミラノ)
  • Year and Date: 2011-09-12
• [Presentation] 骨盤自律神経温存広汎子宮全摘術における下膀胱動脈の臨床解剖学的検討 (2011)
  • Author(s): 加藤一喜、錦見恭子、三橋暁、生水真紀夫, 他
  • Organizer: 第50回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-07-24
• [Presentation] "SURGICAL ANATOMY OF THE VAGINAL AND INFERIOR VESICAL ARTERIES IN NERVE-SPARING RADICAL HYSTERECTOMY" (2011)
  • Author(s): Kazuyoshi Kato
  • Organizer: 17th International Meeting of The European Society of Gynaecological Oncology (ESGO)
  • Place of Presentation: Milan, Italy
• [Presentation] 「骨盤自律神経温存広汎子宮全摘術における下膀胱動脈の臨床解剖学的検討」 (2011)
  • Author(s): 加藤一喜
  • Organizer: 第50回日本婦人科腫瘍学会学術講演会 ワークショップ5 「神経温存広汎子宮全摘術」
  • Place of Presentation: 北海道札幌市
• [Presentation] 進行子宮体癌に対する手術療法の有効性と安全性の検討 (2010)
  • Author(s): 加藤一喜
  • Organizer: 日本婦人科腫瘍学会
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2010-07-08
• [Presentation] 「再発卵巣癌に対する腫瘍減量手術の有効性と安全性の検討」 (2010)
  • Author(s): 加藤一喜
  • Organizer: 第48回日本癌治療学会学術集会 パネルディスカッション19 「再発卵巣がん治療:最先端を覗く」
  • Place of Presentation: 京都府京都市
• [Presentation] 「進行子宮体癌に対する手術療法の有効性と安全性の検討」 (2010)
  • Author(s): 加藤一喜
  • Organizer: 第48回日本婦人科腫瘍学会学術講演会 ワークショップ2 「進行子宮体癌の集学的治療」
  • Place of Presentation: 茨城県つくば市