• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A new strategy for gynecologic malignancy using drug delivery system based on nanomicelles

Research Project

Project/Area Number 22591848
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTeikyo University (2011-2012)
The University of Tokyo (2010)

Principal Investigator

NAKAGAWA Shunsuke  帝京大学, 医学部, 講師 (70270874)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords子宮頸癌 / プロテアソーム阻害剤 / ドラッグデリバリーシステム / ヒトパピローマウイスル / ドラッグデリバリー / 子宮頸がん / HPV / siRNA / ユビキチンプロテアソーム / HPV癌蛋白E6 / 高分子ナノミセル / 分子標的治療
Research Abstract

Human Papillomavirus (HPV) has a crucial role in development of cervical cancer. HPV E6 oncoprotein inactivates tumor suppressors through ubiquitin-mediated degradation. Proteasome inhibitor suppresses degradation of target protein. We designed and created proteasome inhibitor MG132 containing nanomicelle.MG132 containing nanomicelle inhibited growth of xenograft tumor from HPV-positive cervical cancer cell lines. These data underscore the possibility that proteasome inhibitor MG132 containing nanomicelle might be an attractive new strategy for cervical cancer treatment based on drug delivery system.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (31 results)

All 2013 2012 2011 2010 Other

All Journal Article (26 results) (of which Peer Reviewed: 7 results) Presentation (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Retreatment with nedaplatin in patients with recurrent gynecological cancer after the development of hypersensitivity reaction to carboplatin2013

    • Author(s)
      Arimoto T, Oda K, Nakagawa S, Kawana K, Tsukazaki T, Adachi K, Matsumoto Y, Yano T, Kozuma S, Taketani Y
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 39(1) Pages: 336-40

    • Related Report
      2012 Final Research Report
  • [Journal Article] Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines2013

    • Author(s)
      Miyamoto Y, Nakagawa S, Wada-Hiraike O, Seiki T, Tanikawa M, Hiraike H, Sone K, Nagasaka K, Oda K, Kawana K, Nakagawa K, Fujii T, Yano T, Kozuma S, Taketani Y.
    • Journal Title

      Oncol Rep.

      Volume: 29 Issue: 1 Pages: 51

    • DOI

      10.3892/or.2012.2072

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression2012

    • Author(s)
      Shirane A, Wada-Hiraike O, Tanikawa M, Seiki T, Hiraike H, Miyamoto Y, Sone K, Hirano M, Oishi H, Oda K, Kawana K, Nakagawa S, Osuga Y, Fujii T, Yano T, Kozuma S, Taketani Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 424(3) Pages: 604-10

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas2012

    • Author(s)
      Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y
    • Journal Title

      PLoS One

      Volume: 7(5)

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer2012

    • Author(s)
      Ikeda Y, Oda K, Nakagawa S, Murayama-Hosokawa S, Yamamoto S, Ishikawa S, Wang L, Takazawa Y, Maeda D, Wada-Hiraike O, Kawana K, Fukayama M, Aburatani H, Yano T, Kozuma S, Taketani Y
    • Journal Title

      Int J Gynecol Cancer

      Volume: 22(5) Pages: 725-31

    • Related Report
      2012 Final Research Report
  • [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary2012

    • Author(s)
      Morita Y, Wada-Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, Koyama S, Oishi H, Yoshino O, Miyamoto Y, Sone K, Oda K, Nakagawa S, Tsutsui K, Taketani Y
    • Journal Title

      Reprod Biol Endocrinol

      Volume: 10 Pages: 14-14

    • Related Report
      2012 Final Research Report
  • [Journal Article] Interstitial pneumonitis induced by pegylated liposomal doxorubicin in a patient with recurrent ovarian cancer2012

    • Author(s)
      Inaba K, Arimoto T, Hoya M, Kawana K,Nakagawa S, Kozuma S, Taketani Y
    • Journal Title

      Med Oncol

      Volume: 29(2) Pages: 1255-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Second-line chemotherapy with docetaxel and carboplatin in paclitaxel and platinum-pretreated ovarian, fallopian tube, and peritoneal cancer2012

    • Author(s)
      Arimoto T, Nakagawa S, Oda K, Kawana K, Yasugi T, Taketani Y
    • Journal Title

      Med Oncol

      Volume: 29(2) Pages: 1253-4

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genotype-dependent efficacy of a Dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas2012

    • Author(s)
      Shoji K, Oda K, Nakagawa S,-Hiraike O, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e37431-e37431

    • DOI

      10.1371/journal.pone.0037431

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer.2012

    • Author(s)
      Ikeda Y, Oda K, Nakagawa S
    • Journal Title

      Int J Gynecol Cancer

      Volume: 22(5) Issue: 5 Pages: 725-31

    • DOI

      10.1097/igc.0b013e31824c6ea6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: An implicative role of SIRT1 in the ovary2012

    • Author(s)
      Y.Morita, K.Tsutsui, et al
    • Journal Title

      Reprod.Biol.Endocrinbl.

      Volume: 10 Issue: 1 Pages: 14-24

    • DOI

      10.1186/1477-7827-10-14

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells : an implicative role of SIRT1 in the ovary2012

    • Author(s)
      Morita Y, Nakagawa S
    • Journal Title

      Reprod Biol Endocrinol

      Volume: 10 Pages: 14-14

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors2011

    • Author(s)
      Maeda D, Shibahara J, Sakuma T, Isobe M, Teshima S, Mori M, Oda K, Nakagawa S, Taketani Y, Ishikawa S, Fukayama M
    • Journal Title

      Am J Surg Pathol

      Volume: 35(10) Pages: 1429-40

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function2011

    • Author(s)
      Tanikawa M, Wada-Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
    • Journal Title

      Br J Cancer

      Volume: 104(8) Pages: 1349-55

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Rsf-1 (HBXAP) expression is associated with advanced stage and lymph node metastasis in ovarian clear cell carcinoma2011

    • Author(s)
      Maeda D, Chen X, Guan B, Nakagawa S, Yano T, Taketani Y, Fukayama M, Wang TL, Shih IeM
    • Journal Title

      Int J Gynecol Pathol

      Volume: 30(1) Pages: 30-5

    • Related Report
      2012 Final Research Report
  • [Journal Article] Aromatase inhibitor anastrozole as a second-line hormonal treatment to a recurrent low-grade endometrial stromal sarcoma: a case report2011

    • Author(s)
      Shoji K, Oda K, Nakagawa S, Kawana K, Yasugi T, Ikeda Y, Takazawa Y, Kozuma S, Taketani Y
    • Journal Title

      Med Oncol

      Volume: 28(3) Pages: 771-4

    • Related Report
      2012 Final Research Report
  • [Journal Article] The mechanism and implications of hScrib regulation of ERK2010

    • Author(s)
      Nagasaka K, Massimi P, Pim D, Subbaiah VK, Kranjec C, Nakagawa S, Yano T, Taketani Y, Banks L
    • Journal Title

      Small GTPases

      Volume: 1(2) Pages: 108-112

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mucosal carcinoma of the fallopian tube coexists with ovarian cancer of serous subtype only: a study of Japanese cases2010

    • Author(s)
      Maeda D, Ota S, Takazawa Y, Ohashi K, Mori M, Imamura T, Nakagawa S, Yano T, Taketani Y, Fukayama M
    • Journal Title

      Virchows Arch

      Volume: 457(5) Pages: 597-608

    • Related Report
      2012 Final Research Report
  • [Journal Article] The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction2010

    • Author(s)
      Nagasaka K, Pim D, Massimi P, Thomas M, Tomaic V, Subbaiah VK, Kranjec C, Nakagawa S, Yano T, Taketani Y, Myers M, Banks L
    • Journal Title

      Oncogene

      Volume: 29(38) Pages: 5311-21

    • Related Report
      2012 Final Research Report
  • [Journal Article] Bilateral microscopic adenocarcinoma of the fallopian tubes detected by an endometrial cytologic smear2010

    • Author(s)
      Maeda D, Takazawa Y, Ota S, Takeuchi Y, Seta A, Nakagawa S, Yano T, Taketani Y, Fukayama M
    • Journal Title

      Int J Gynecol Pathol

      Volume: 29(3) Pages: 273-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of DBC1 as a transcriptional repressor for BRCA12010

    • Author(s)
      Hiraike H, Wada-Hiraike O, Nakagawa S, Koyama S, Miyamoto Y, Sone K, Tanikawa M, Tsuruga T, Nagasaka K, Matsumoto Y, Oda K, Shoji K, Fukuhara H, Saji S, Nakagawa K, Kato S, Yano T, Taketani Y
    • Journal Title

      Br J Cancer

      Volume: 102(6) Pages: 1061-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] Repression of estrogen receptor beta function by putative tumor suppressor DBC12010

    • Author(s)
      Koyama S, Wada-Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, Sone K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 392(3) Pages: 357-62

    • Related Report
      2012 Final Research Report
  • [Journal Article] Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway2010

    • Author(s)
      Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H
    • Journal Title

      Oncogene

      Volume: 29(13) Pages: 1897-908

    • Related Report
      2012 Final Research Report
  • [Journal Article] Clinicopathological Significance of Loss of ARID1A Immunoreactivity in Ovarian Clear Cell Carcinoma2010

    • Author(s)
      Maeda D, Mao TL, Fukayama M, Nakagawa S, Yano T, Taketani Y, Shih IeM
    • Journal Title

      Int J Mol Sci

      Volume: 11(12) Pages: 5120-8

    • NAID

      120007089060

    • Related Report
      2012 Final Research Report
  • [Journal Article] Identification of DBC1 as a transcriptional repressor for BRCA1.2010

    • Author(s)
      Hiraike H, Wada-Hiraike O, Nakagawa S
    • Journal Title

      Br J Cancer

      Volume: 102 Pages: 1061-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway.2010

    • Author(s)
      Murayama-Hosokawa S, Oda K, Nakagawa S
    • Journal Title

      Oncogene

      Volume: 29 Pages: 1897-908

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 臓器別シンポジウム:子宮頸癌2011

    • Author(s)
      中川俊介
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋・名古屋国際会議場
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] プルテアソーム阻害剤をもちいた新規子宮頸癌の治療戦略2011

    • Author(s)
      中川俊介
    • Organizer
      日本癌学会 臓器別シンポジューム
    • Related Report
      2012 Final Research Report
  • [Presentation] Deleted in breast cancer-1 is targeted for the ubiquitin-mediated degradation by human papillomavirus E6 oncoprotein.2010

    • Author(s)
      Takayuki Seiki, Shunsuke Nakagawa
    • Organizer
      69^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] FIGO 2012 Rome ItalyGenome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer

    • Author(s)
      Ikeda Y, Oda K, Nakagawa S
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] プロテアソームインヒビター内包高分子ミセル2010

    • Inventor(s)
      片岡一則、中川俊介他
    • Industrial Property Rights Holder
      片岡一則、中川俊介他
    • Filing Date
      2010-02-19
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi