A new strategy for gynecologic malignancy using drug delivery system based on nanomicelles
Project/Area Number |
22591848
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Teikyo University (2011-2012) The University of Tokyo (2010) |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 子宮頸癌 / プロテアソーム阻害剤 / ドラッグデリバリーシステム / ヒトパピローマウイスル / ドラッグデリバリー / 子宮頸がん / HPV / siRNA / ユビキチンプロテアソーム / HPV癌蛋白E6 / 高分子ナノミセル / 分子標的治療 |
Research Abstract |
Human Papillomavirus (HPV) has a crucial role in development of cervical cancer. HPV E6 oncoprotein inactivates tumor suppressors through ubiquitin-mediated degradation. Proteasome inhibitor suppresses degradation of target protein. We designed and created proteasome inhibitor MG132 containing nanomicelle.MG132 containing nanomicelle inhibited growth of xenograft tumor from HPV-positive cervical cancer cell lines. These data underscore the possibility that proteasome inhibitor MG132 containing nanomicelle might be an attractive new strategy for cervical cancer treatment based on drug delivery system.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Sequential effects of the proteasome inhibitor bortezomib and chemotherapeutic agents in uterine cervical cancer cell lines.2013
Author(s)
Miyamoto Y, Nakagawa S, Wada-Hiraike O, Seiki T, Tanikawa M, Hiraike H, Sone K, Nagasaka K, Oda K, Kawana K, Nakagawa K, Fujii T, Yano T, Kozuma S, Taketani Y.
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Journal Title
Oncol Rep.
Volume: 29(1)
Issue: 1
Pages: 51-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression2012
Author(s)
Shirane A, Wada-Hiraike O, Tanikawa M, Seiki T, Hiraike H, Miyamoto Y, Sone K, Hirano M, Oishi H, Oda K, Kawana K, Nakagawa S, Osuga Y, Fujii T, Yano T, Kozuma S, Taketani Y
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Journal Title
Biochem Biophys Res Commun
Volume: 424(3)
Pages: 604-10
Related Report
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[Journal Article] Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas2012
Author(s)
Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y
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Journal Title
Related Report
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[Journal Article] Genome-wide single nucleotide polymorphism arrays as a diagnostic tool in patients with synchronous endometrial and ovarian cancer2012
Author(s)
Ikeda Y, Oda K, Nakagawa S, Murayama-Hosokawa S, Yamamoto S, Ishikawa S, Wang L, Takazawa Y, Maeda D, Wada-Hiraike O, Kawana K, Fukayama M, Aburatani H, Yano T, Kozuma S, Taketani Y
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Journal Title
Int J Gynecol Cancer
Volume: 22(5)
Pages: 725-31
Related Report
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[Journal Article] Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary2012
Author(s)
Morita Y, Wada-Hiraike O, Yano T, Shirane A, Hirano M, Hiraike H, Koyama S, Oishi H, Yoshino O, Miyamoto Y, Sone K, Oda K, Nakagawa S, Tsutsui K, Taketani Y
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Journal Title
Reprod Biol Endocrinol
Volume: 10
Pages: 14-14
Related Report
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[Journal Article] Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.2012
Author(s)
Shoji K, Oda K, Nakagawa S,-Hiraike O, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y.
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Journal Title
PLoS One
Volume: 7(5):
Issue: 5
Pages: e37431-e37431
DOI
Related Report
Peer Reviewed
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[Journal Article] β-catenin (CTNNB1) S33C mutation in ovarian microcystic stromal tumors2011
Author(s)
Maeda D, Shibahara J, Sakuma T, Isobe M, Teshima S, Mori M, Oda K, Nakagawa S, Taketani Y, Ishikawa S, Fukayama M
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Journal Title
Am J Surg Pathol
Volume: 35(10)
Pages: 1429-40
Related Report
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[Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function2011
Author(s)
Tanikawa M, Wada-Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Br J Cancer
Volume: 104(8)
Pages: 1349-55
Related Report
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[Journal Article] The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction2010
Author(s)
Nagasaka K, Pim D, Massimi P, Thomas M, Tomaic V, Subbaiah VK, Kranjec C, Nakagawa S, Yano T, Taketani Y, Myers M, Banks L
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Journal Title
Oncogene
Volume: 29(38)
Pages: 5311-21
Related Report
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[Journal Article] Identification of DBC1 as a transcriptional repressor for BRCA12010
Author(s)
Hiraike H, Wada-Hiraike O, Nakagawa S, Koyama S, Miyamoto Y, Sone K, Tanikawa M, Tsuruga T, Nagasaka K, Matsumoto Y, Oda K, Shoji K, Fukuhara H, Saji S, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Br J Cancer
Volume: 102(6)
Pages: 1061-7
Related Report
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[Journal Article] Repression of estrogen receptor beta function by putative tumor suppressor DBC12010
Author(s)
Koyama S, Wada-Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, Sone K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Biochem Biophys Res Commun
Volume: 392(3)
Pages: 357-62
Related Report
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[Journal Article] Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway2010
Author(s)
Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H
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Journal Title
Oncogene
Volume: 29(13)
Pages: 1897-908
Related Report
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