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Investigation for the molecular mechanism of the association between obesity and endometrial cancer

Research Project

Project/Area Number 22591849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNiigata University

Principal Investigator

YAHATA Yetsuro  新潟大学, 医歯学系, 准教授 (90293232)

Co-Investigator(Kenkyū-buntansha) QUAN Jinhua  新潟大学, 医歯学系, 助教 (10452070)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords子宮体癌 / Leptin / 肥満 / レプチン / アディポサイトカイン / アディポネクチン
Research Abstract

We demonstrated the presence of elevated leptin and leptin/adiponectin (L/A) ratios in Japanese postmenopausal endometrial cancer patients. The leptin and L/A ratios were associated with an increased risk of endometrial cancer development after the normalization of the BMI, suggesting that the leptin and L/A ratio is a predictor of endometrial cancer risk, independent of obesity. Elevated Cyclin D1 expression was observed after leptin treatment for endometrial cancer cells and JAK/STAT pathway was mainly associated for the expression of CyclinD1. Estrogen and leptin stimulated endometrial cancer cell proliferation in a coordinated manner.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] 女性のライフサイクルと肥満2011

    • Author(s)
      八幡哲郎
    • Journal Title

      日本女性医学会誌

      Volume: 19巻 Pages: 96-101

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] ウェルエイジングのために-中高年女性のQOLとヘルスケア-女性のライフサイクルと肥満対策-2011

    • Author(s)
      八幡哲郎
    • Journal Title

      産婦人科治療

      Volume: 103巻 Pages: 77-84

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] がん診療サポートガイド「子宮体癌」2011

    • Author(s)
      八幡哲郎
    • Journal Title

      治療

      Volume: 93巻 Pages: 1129-1131

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 子宮体癌トピックス:肥満と子宮体癌2010

    • Author(s)
      八幡哲郎
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 62巻 Pages: 236-241

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Gynecologic Oncology, Serum leptin-adiponectin ratio and endometrial cancer risk in postmenopausal female subjects2010

    • Author(s)
      Ashizawa N., Yahata T., et.al
    • Journal Title

      Gynecologic Oncology

      Volume: 119 Pages: 65-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum leptin-adiponectin ratio and endometrial cancer risk in postmenopausal female subjects.2010;119: 65-9.2010

    • Author(s)
      Ashizawa N., Yahata T., et.al
    • Journal Title

      Gynecologic Oncology

      Volume: 119 Pages: 65-69

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血清レプチン/アディポネクチン比と子宮体癌発症リスク2011

    • Author(s)
      芦澤直浩、八幡哲郎
    • Organizer
      第50回日本婦人科腫瘍学会(ミニシンポジウム)
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 血清レプチン/アディポネクチン比と子宮体癌発症リスク2011

    • Author(s)
      芦澤直浩、八幡哲郎
    • Organizer
      第50回日本婦人科腫瘍学会(ミニシンポジウム)
    • Place of Presentation
      北海道札幌市札幌コンベンションセンター
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌とアディポサイトカイン2011

    • Author(s)
      八幡哲郎
    • Organizer
      第59回北日本産科婦人科学会学術講演会(招請講演)
    • Place of Presentation
      秋田県秋田市
    • Year and Date
      2011-09-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮体癌とアディポサイトカイン2011

    • Author(s)
      八幡哲郎
    • Organizer
      第59回北日本産科婦人科学会学術講演会
    • Place of Presentation
      秋田県秋田市秋田キャッスルホテル(招請講演)
    • Year and Date
      2011-09-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮体癌発症と耐糖能異常およびレプチンの関連性についての検討2010

    • Author(s)
      芦澤直浩、八幡哲郎
    • Organizer
      第25回日本更年期医学会学術集会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2010-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 女性のライフサイクルと肥満2010

    • Author(s)
      八幡哲郎
    • Organizer
      第25回日本更年期医学会学術集会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2010-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 女性のライフサイクルと肥満2010

    • Author(s)
      八幡哲郎
    • Organizer
      第25会日本更年期医学会学術集会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2010-10-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体癌発症と耐糖能異常およびレプチンの関連性についての検討2010

    • Author(s)
      芦澤直浩、八幡哲郎
    • Organizer
      第25会日本更年期医学会学術集会
    • Place of Presentation
      鹿児議翻所
    • Year and Date
      2010-10-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体癌トピックス:肥満と子宮体癌2010

    • Author(s)
      八幡哲郎
    • Organizer
      第62回日本産科婦人科学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-04-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮体癌トピックス:肥満と子宮体癌2010

    • Author(s)
      八幡哲郎
    • Organizer
      第62会日本産科婦人科学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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