| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Research Abstract |
We demonstrated the presence of elevated leptin and leptin/adiponectin (L/A) ratios in Japanese postmenopausal endometrial cancer patients. The leptin and L/A ratios were associated with an increased risk of endometrial cancer development after the normalization of the BMI, suggesting that the leptin and L/A ratio is a predictor of endometrial cancer risk, independent of obesity. Elevated Cyclin D1 expression was observed after leptin treatment for endometrial cancer cells and JAK/STAT pathway was mainly associated for the expression of CyclinD1. Estrogen and leptin stimulated endometrial cancer cell proliferation in a coordinated manner.
|
