The analysis of novel molecular targeted therapy inhibiting S100A4 for ovarian cancer
| Project/Area Number |
22591850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
HORIUCHI Akiko 信州大学, 医学部附属病院, 特任研究員 (80334895)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Norihiko 信州大学, 医学部附属病院, 助教 (50447728)
FUSEYA Chiho 信州大学, 医学部附属病院, 助教(診療) (50447736)
SHIOZAWA Tanri 信州大学, 医学部, 教授 (20235493)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 卵巣癌 / 分子標的薬 / S100A4 |
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| Research Abstract |
We revealed that the Hypoxia Response Element(HRE) existing in -4 to +248 on the region from promoter to intron in S100A4 gene was important for its over-expression in ovarian carcinoma cells. Thus, low oxygen environment was considered to up-regulate the expression of S100A4. Next, we performed the screening of compounds suppressing the transcription of S100A4 gene using compounds library containing 10,000 kinds of compound. We found 6 kinds of compound significantly suppressing the transcription of its gene. These were regarded as a candidate compound for novel molecular targeted therapy.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h12012
Author(s)
Hayashi T,Horiuchi A,Sano K,Hiraoka N,Kasai M,Ichimura T,Sudo T,Nishimura R,Ishiko O,Shiozawa T,Kanai Y,Yaegashi N,Aburatani H,Konishi I.
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Journal Title
FEBS Lett
Volume: 586
Issue: 13
Pages: 1824-31
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy2011
Author(s)
Hayashi, T, A.Horiuchi, K.Sano, N.Hiraoka, M.Kasai, T.Ichimura, T.Sudo, Y.Tagawa, R.Nishimura, Ol Ishiko, Y.Kanai, N.Yaegashi, H.Aburatani, T.Shiozawa, I.Konishi
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Journal Title
Sci Rep
Volume: 1
Issue: 1
Pages: 180-180
DOI
Related Report
Peer Reviewed
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[Journal Article] Oct4 expression in immature teratoma of the ovary: relevance to histologic grade and degree of differentiation.2010
Author(s)
Abiko K,Mandai M,Hamanishi J,Matsumura N,Baba T,Horiuchi A,Mikami Y,Yoshioka S,WakasaT,Shiozawa T,Konishi I..
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Journal Title
Am J Surg Patbo1.
Volume: 34
Pages: 1842-8
Related Report
Peer Reviewed
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