| Project/Area Number |
22591850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Shinshu University |
|---|
Principal Investigator |
HORIUCHI Akiko 信州大学, 医学部附属病院, 特任研究員 (80334895)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Norihiko 信州大学, 医学部附属病院, 助教 (50447728)
FUSEYA Chiho 信州大学, 医学部附属病院, 助教(診療) (50447736)
SHIOZAWA Tanri 信州大学, 医学部, 教授 (20235493)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
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| Keywords | 卵巣癌 / 分子標的薬 / S100A4 |
|---|
| Research Abstract |
We revealed that the Hypoxia Response Element(HRE) existing in -4 to +248 on the region from promoter to intron in S100A4 gene was important for its over-expression in ovarian carcinoma cells. Thus, low oxygen environment was considered to up-regulate the expression of S100A4. Next, we performed the screening of compounds suppressing the transcription of S100A4 gene using compounds library containing 10,000 kinds of compound. We found 6 kinds of compound significantly suppressing the transcription of its gene. These were regarded as a candidate compound for novel molecular targeted therapy.
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