| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Present study of 112 cases demonstrated that over 90% cases of adenocarcinoma including minimal deviation adenocarcinoma (MDA) could be distinguished from benign lesion of the cervix such as lobular endocervical glandular hyperplasia (LEGH) by magnetic resonance imaging (MRI), Papanicolaou cytology and cone biopsy. The clonality analysis revealed that 4 of 6 LEGH lesions associated with MDA or adenocarcinoma were monoclonal, and the patterns of X chromosome inactivation in monoclonal LEGH lesions were identical to those in coexisting malignant lesions. The mutation of STK11 was only identified in one MDA, but not in LEGH. These results indicated that a subset of LEGH may be a precursor to malignant tumors including MDA.
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