The functional analysis of lipocalin2 and novel molecular targeted therapy for endometrial carcinoma
| Project/Area Number |
22591852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Tsutomu 信州大学, 医学部附属病院, 講師 (70418721)
SHIOZAWA Tanri 信州大学, 医学部, 教授 (20235493)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌 / 核酸 / タンパク質 / 発現制御 / 子宮内膜癌 / lipocalin2 / SLC22A17 / 生存能力 / 紫外線感受性 / シスプラチン感受性 / アポトーシス |
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| Research Abstract |
The expression of lipocalin2 (LCN2) was silenced using shRNA in HHUA, an endometrial carcinoma cell line over-expressing LCN2. The cell viability was significantly reduced and the apoptotic cells were significantly increased in this LCN2-silenced HHUA after ultraviolet (UV) irradiation or cisplatin (CDDP) treatment. The iron-chelating also reduced cell viability similar to LCN2-suppression. The expression of phosphorylated Akt was reduced in LCN2-silenced HHUA. These findings suggested that LCN2 enhanced cell survival via iron and Akt phosphorylation.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular endocervical glandular hyperplasia of the uterine cervix: a multicenter study of clinicopathology and magnetic resonance imaging findings2011
Author(s)
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I
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Journal Title
Int J Gynecol Cancer
Volume: 21
Pages: 1287-96
Related Report
Peer Reviewed
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