| Project/Area Number |
22591860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yokohama City University |
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Principal Investigator |
MIYAGI Etsuko 横浜市立大学, 附属病院, 准教授 (40275053)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAHARA Fumiki 横浜市立大学, 医学研究科, 教授 (30201734)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAGI Yohei 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態学部, 総括部長 (00254194)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 婦人科腫瘍学 / 卵巣癌 / 卵巣明細胞腺癌 / アネキシンA4 / 浸潤 / 増殖 / 薬剤耐性 / 転移 / 明細胞腺癌 |
|---|
| Research Abstract |
The annexin A4 (ANXA4), one of the highly expressed proteins in ovarian clear cell adenocarcinoma (OCCA), which is typically chemo-resistant and poor-prognosis disease, was our research target. Two OCCA cell lines in which ANXA4 expression is suppressed by shRNA were used. Significantly restricted proliferation and increased chemo-sensitivity were recognized in an acidic-ANXA4-expressing cell, whereas decreased invasiveness was detected in a basic-ANXA4-expressing cell.
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