• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidating a determinant of development as a novel therapeutic target of ovarian clear cell adenocarcinoma

Research Project

Project/Area Number 22591860
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionYokohama City University

Principal Investigator

MIYAGI Etsuko  横浜市立大学, 附属病院, 准教授 (40275053)

Co-Investigator(Kenkyū-buntansha) HIRAHARA Fumiki  横浜市立大学, 医学研究科, 教授 (30201734)
Co-Investigator(Renkei-kenkyūsha) MIYAGI Yohei  地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態学部, 総括部長 (00254194)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords婦人科腫瘍学 / 卵巣癌 / 卵巣明細胞腺癌 / アネキシンA4 / 浸潤 / 増殖 / 薬剤耐性 / 転移 / 明細胞腺癌
Research Abstract

The annexin A4 (ANXA4), one of the highly expressed proteins in ovarian clear cell adenocarcinoma (OCCA), which is typically chemo-resistant and poor-prognosis disease, was our research target. Two OCCA cell lines in which ANXA4 expression is suppressed by shRNA were used. Significantly restricted proliferation and increased chemo-sensitivity were recognized in an acidic-ANXA4-expressing cell, whereas decreased invasiveness was detected in a basic-ANXA4-expressing cell.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (1 results)

  • [Journal Article] HIF2α-Sp1 interaction mediates a deacetylation-dependent FVII-gene activation under hypoxic conditions in ovarian cancer cells2012

    • Author(s)
      Koizume S, Ito S, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Osaka H, Takano Y, Ruf W, Miyagi Y
    • Journal Title

      Nucleic Acid Research

      Volume: 40(12) Issue: 12 Pages: 5389-5401

    • DOI

      10.1093/nar/gks201

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Research Group for Development of Cervical Cancer Screening Guidelines : The Japanese guideline for cervical cancer screening2010

    • Author(s)
      Hamashima C
    • Journal Title

      Jpn J Clin Oncol

      Volume: 40 Pages: 485-502

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮体部原発扁平上皮癌の1例2010

    • Author(s)
      長谷川哲哉
    • Journal Title

      日本臨床細胞学会神奈川県支部会誌

      Volume: 15 Pages: 65-70

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JEB(carboplatin,etoposide,bleomycin)療法を施行した卵巣悪性胚細胞腫瘍の4例2010

    • Author(s)
      横須賀とも子
    • Journal Title

      小児がん

      Volume: 47 Pages: 111-115

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Functional analysis of annexin A4 and the implication in ovarian clear cell adenocarcinoma (OCCA) phenotypes2012

    • Author(s)
      Mogami T, Yokota N, Yoshihara M, Nakamura Y, Sakuma Y, Koizume S, Asai-Sato M, Miyagi E, Hirahara F, Miyagi Y
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2012-04-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 卵巣明細胞腺癌で高発現する annexin A4 の機能解析2012

    • Author(s)
      最上多恵,横田奈朋,佐藤美紀子,沼崎令子,宮城悦子,平原史樹
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸ポートピアホテル、神戸国際展示場(兵庫県)
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional analysis of annexin A4 and the implication in ovarian clear cell adenocarcinoma (OCCA) phenotypes2012

    • Author(s)
      Mogami T, Yokota N, Yoshihara M, Nakamura Y, Sakuma Y, Koizume S, Asai-Sato M, Miyagi E, Hirahara F, Miyagi Y
    • Organizer
      The 3rdJohnsHopkins Ovarian Cancer Symposium
    • Place of Presentation
      Baltimore, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional analysis of annexin A4 and the implication in ovarian clear cell adenocarcinoma (OCCA) phenotypes2012

    • Author(s)
      Mogami T
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 卵巣明細胞腺癌で高発現するannexin A4の機能解析2012

    • Author(s)
      最上多恵
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸ポートピアホテル・神戸国際展示場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional analysis of annexinA4 and the implication in ovarian clear cell adenocarcinoma (OCCA) phenotypes2011

    • Author(s)
      最上多恵
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣明細胞腺癌における ANXA4 発現の解析2011

    • Author(s)
      最上多恵,横田奈朋,常住 淳,辻祥太郎,小井詰史郎,佐藤美紀子,宮城悦子,宮城洋平,平原史樹
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      松江しんじ湖温泉ホテル(島根県)
    • Year and Date
      2011-07-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 卵巣明細胞腺癌におけるANXA4発現の解析2011

    • Author(s)
      最上多恵
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      松江しんじ湖温泉ホテル一畑(島根県)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Book] よくわかる最新医学子宮がん2010

    • Author(s)
      監修:宮城悦子
    • Total Pages
      150
    • Publisher
      主婦の友社
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi