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Oxidative stress in the pathogenesis of clear cell carcinoma of the ovary.

Research Project

Project/Area Number 22591862
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNara Medical University

Principal Investigator

YOSHIDA Shozo  奈良県立医科大学, 医学部, 助教 (40347555)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Hiroshi  奈良県立医科大学, 医学部, 教授 (40178330)
YAMADA Yoshihiko  奈良県立医科大学, 医学部, 講師 (80275346)
OI Hidekazu  奈良県立医科大学, 医学部, 准教授 (10283368)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords卵巣明細胞腺癌 / HNF-1beta、 chk1 / 細胞周期 / ノックダウン / Bleomycin / CD44 / チェックポイント機構 / 酸化ストレス / HNF-1beta / chk1 / chk1 inhibitor / sn38
Research Abstract

There is a lot of pathological evidence to suggest the theory that carcinoma of the ovary develops from endometrial tissue.Endometrial tissue expands with blood and then sheds the blood during menstruation. Red Blood Cells contain an iron-rich protein, hemoglobin. Iron overload is associated with carcinogenesis. In addition, the Fenton reaction may cause oxidative damage at a specific part of the genome. Hepatocyte nuclear factor-1beta (HNF-1beta), a transcription factor overexpressed in clear cell adenocarcinoma, might sustain chk1 protein phosphorylation to arrest the cell cycle and inhibit cell death induced by an anticancer agent. And, expression of CD44 is an important facter in endometriosis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (8 results)

  • [Journal Article] The role of components of the chromatin modification machinery in carcinogenesis of clear cell carcinoma of the ovary2012

    • Author(s)
      Shigetomi H, Oonogi A, Tsunemi T, Tanase Y, Yamada Y, Kajihara H, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H
    • Journal Title

      Oncology letters

      Volume: 2(4) Pages: 591-597

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of components of the chromatin modification machinery in carcinogenesis of clear cell carcinoma of the ovary2012

    • Author(s)
      Shigetomi H, Oonogi A, Tsunemi T, Tanase Y, Yamada Y, Kajihara H, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H.
    • Journal Title

      Oncology letters

      Volume: 2 Issue: 4 Pages: 591-597

    • DOI

      10.3892/ol.2011.316

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary2011

    • Author(s)
      Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21(7) Pages: 1200-7

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New insights into pattern recognition receptors and their ligands in gynecologic pathologies2011

    • Author(s)
      Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H
    • Journal Title

      Human immunology

      Volume: 72(3) Pages: 213-218

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 卵巣チョコレート胞に合併する明細胞腺癌と類内膜腺癌の発生病理と,その遺伝子特性2011

    • Author(s)
      重富洋志, 吉田昭三
    • Journal Title

      日本エンドメトリオーシス学会会誌

      Volume: 32 Pages: 43-48

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Molecular genetics and epidemiology of epithelial ovarian cancer2011

    • Author(s)
      Haruta S, Yoshida S
    • Journal Title

      Oncol Rep

      Volume: 26(6) Pages: 1347-56

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New insights into pattern recognition receptors and their ligands in gynecologic pathologies.2011

    • Author(s)
      Yamada Y, Shigetomi H, Yoshida S
    • Journal Title

      Human immunology

      Volume: 72(3) Pages: 213-218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 卵巣チョコレート嚢胞に合併する明細胞腺癌と類内膜腺癌の発生病理と、その遺伝子特性2010

    • Author(s)
      重富洋志、吉澤順子、山田嘉彦、川口龍二、吉田昭三、古川直人、大井豪一、小林浩
    • Journal Title

      日本エンドメトリオーシス学会会誌

      Volume: 32巻 Pages: 43-48

    • Related Report
      2012 Final Research Report
  • [Journal Article] 卵巣明細胞腺癌における転写因子 HNF-1beta のターゲット遺伝子の網羅的検索2010

    • Author(s)
      重富洋志、吉澤順子、山田嘉彦、川口龍二、吉田昭三、大井豪一、小林浩
    • Journal Title

      日本エンドメトリオーシス学会会誌

      Volume: 31巻 Pages: 70-74

    • Related Report
      2012 Final Research Report
  • [Journal Article] New insights into the pathophysiology of endometriosis : from chronic in flammation to danger signal.2010

    • Author(s)
      Kajihara H, Yoshida S
    • Journal Title

      Gynecological endocrinology

      Volume: 27(2) Pages: 73-79

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anticancer agents combined with Chk1 inhibitor sensitize HNF-1beta overexpressing clear cell adenocarcinoma of the ovary2012

    • Author(s)
      Hiroshi Shigetomi, Yoriko Yoshizawa, Seiji Kanayama, Ryuji Kawaguchi, Hiroshi Kobayashi, Tamotsu Sudo
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 明細胞腺癌における転写因子HNF-1beta のDNA損傷チェックポイント機構の制御2012

    • Author(s)
      重富洋志、吉澤順子、金山清二、山田嘉彦、川口龍二、吉田昭三、古川直人、大井豪一、小林浩
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Investigation into the biological functions of hepatocyte nuclear factor-1beta in clear sell adenocarcinoma of the ovary2011

    • Author(s)
      H. Shigetomi ,Y. Yoshizawa, Y. Yamada, R. Kawaguchi, S. Yoshida, N. Furukawa, H. Oi, H. Kobayashi, S. Kanayama, T. Sudo
    • Organizer
      17th International Meeting of the European Society of Gynaecological Oncology (ESGO)
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Investigation into the biological functions of hepatocyte nuclear factor-1 beta in clear sell adenocarcinoma of the ovary2011

    • Author(s)
      H.Shigetomi, S Yoshida
    • Organizer
      17th International Meeting of the European Society of Gynaecological Oncology (ESGO)
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣チョコレート嚢胞に合併する明細胞腺癌と類内膜腺癌の発生病理と、その遺伝子特性2011

    • Author(s)
      重富洋志, 吉田昭三
    • Organizer
      第32回日本エンドメトリオーシス学会(シンポジウム演者)
    • Place of Presentation
      東京
    • Year and Date
      2011-01-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣チョコレート嚢胞に合併する明細胞腺癌と類内膜腺癌の発生病理と、その遺伝子特性2011

    • Author(s)
      重富洋志、吉澤順子、山田嘉彦、川口龍二、小林浩
    • Organizer
      第32回日本エンドメトリオーシス学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-01-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Investigation into the biological functions of Hepatocyte Nuclear Factor-1beta in the clear cell adenocarcinoma of ovary2010

    • Author(s)
      Shigetomi H Yoshida S
    • Organizer
      The 1^<st> Asian Conference on Endometriosis
    • Place of Presentation
      上海
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 明細胞腺癌における転写因子HNF-1beta のDNA損傷チェックポイント機構の制御

    • Author(s)
      重富洋志、吉澤順子、金山清二、山田嘉彦、川口龍二、吉田昭三、古川直人、大井豪一、小林浩
    • Organizer
      日本産科婦人科学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2012 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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