Oxidative stress in the pathogenesis of clear cell carcinoma of the ovary.
| Project/Area Number |
22591862
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nara Medical University |
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Principal Investigator |
YOSHIDA Shozo 奈良県立医科大学, 医学部, 助教 (40347555)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hiroshi 奈良県立医科大学, 医学部, 教授 (40178330)
YAMADA Yoshihiko 奈良県立医科大学, 医学部, 講師 (80275346)
OI Hidekazu 奈良県立医科大学, 医学部, 准教授 (10283368)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 卵巣明細胞腺癌 / HNF-1beta、 chk1 / 細胞周期 / ノックダウン / Bleomycin / CD44 / チェックポイント機構 / 酸化ストレス / HNF-1beta / chk1 / chk1 inhibitor / sn38 |
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| Research Abstract |
There is a lot of pathological evidence to suggest the theory that carcinoma of the ovary develops from endometrial tissue.Endometrial tissue expands with blood and then sheds the blood during menstruation. Red Blood Cells contain an iron-rich protein, hemoglobin. Iron overload is associated with carcinogenesis. In addition, the Fenton reaction may cause oxidative damage at a specific part of the genome. Hepatocyte nuclear factor-1beta (HNF-1beta), a transcription factor overexpressed in clear cell adenocarcinoma, might sustain chk1 protein phosphorylation to arrest the cell cycle and inhibit cell death induced by an anticancer agent. And, expression of CD44 is an important facter in endometriosis.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] The role of components of the chromatin modification machinery in carcinogenesis of clear cell carcinoma of the ovary2012
Author(s)
Shigetomi H, Oonogi A, Tsunemi T, Tanase Y, Yamada Y, Kajihara H, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H
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Journal Title
Oncology letters
Volume: 2(4)
Pages: 591-597
Related Report
Peer Reviewed
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[Journal Article] The role of components of the chromatin modification machinery in carcinogenesis of clear cell carcinoma of the ovary2012
Author(s)
Shigetomi H, Oonogi A, Tsunemi T, Tanase Y, Yamada Y, Kajihara H, Yoshizawa Y, Furukawa N, Haruta S, Yoshida S, Sado T, Oi H, Kobayashi H.
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Journal Title
Oncology letters
Volume: 2
Issue: 4
Pages: 591-597
DOI
Related Report
Peer Reviewed
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[Journal Article] Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary2011
Author(s)
Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H
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Journal Title
Int J Gynecol Cancer
Volume: 21(7)
Pages: 1200-7
Related Report
Peer Reviewed
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[Journal Article] New insights into pattern recognition receptors and their ligands in gynecologic pathologies2011
Author(s)
Yamada Y, Shigetomi H, Onogi A, Haruta S, Kawaguchi R, Yoshida S, Furukawa N, Nagai A, Tanase Y, Tsunemi T, Oi H, Kobayashi H
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Journal Title
Human immunology
Volume: 72(3)
Pages: 213-218
Related Report
Peer Reviewed
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[Presentation] Investigation into the biological functions of hepatocyte nuclear factor-1beta in clear sell adenocarcinoma of the ovary2011
Author(s)
H. Shigetomi ,Y. Yoshizawa, Y. Yamada, R. Kawaguchi, S. Yoshida, N. Furukawa, H. Oi, H. Kobayashi, S. Kanayama, T. Sudo
Organizer
17th International Meeting of the European Society of Gynaecological Oncology (ESGO)
Place of Presentation
Milano, Italy
Year and Date
2011-09-14
Related Report
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