Establishment of gene scoring model to predict the effect of anticancer drug in ovarian cancer and the screening of the new molecular target

Research Project

Project/Area Number	22591865
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Obstetrics and gynecology
Research Institution	Keio University
Principal Investigator	TSUDA Hiroshi 慶應義塾大学, 医学部, 講師 (00423880)
Co-Investigator(Kenkyū-buntansha)	MIKI Yoshio 東京医科歯科大学, 難治疾患研究所, 教授 (10281594)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	婦人科腫瘍学 / 上皮性卵巣がん / TC療法 / 効果予測 / トランスフェクションアレイ / 上皮性卵巣癌 / パクリタキセル / プラチナ製剤 / 薬剤耐性 / 細胞アレイ / predictive marker
Research Abstract	In this study, we determined the genes to predict the effect of TC regimen (CBDCA+PTX) in epithelial ovarian cancer. At first, we screened 155 genes to predict the effect of TC regimen for 25 ovarian cancer patients with measurable disease, and made the t

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(4 results)