The mechanism of acquisition of metastatic and invasive capacityin endometrial cancer cell

• Project/Area Number: 22591868
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Juntendo University
• Principal Investigator: TERAO Yasuhisa 順天堂大学, 医学部, 准教授 (00348997)
• Co-Investigator(Kenkyū-buntansha): KATO Kiyoko 順天堂大学, 医学部, 准教授 (10253527)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 子宮体癌 / 癌幹細胞 / EMT / 転移能 / SPARC / 幹細胞 / 転移 / シグナル伝達 / side population細胞

Research Abstract

We select SPARC (secreted protein acidic and rich in cystein) from the gene clusters which revelation is increasing to the endometrial cancer stem cell, and analyzed it. There is no-expression of SPARC in normal endometrium, but highly expressed in the endometrial cancer, especially in poorly differentiated adenocarcinoma of uterine corpus. These data showed that SPARC was associated with micro-environment of tumor-stroma formation and the migration capability.

Research Products

• [Journal Article] The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells (2013)
  • Author(s): Kusunoki S
  • Journal Title: Gynecol Oncol Volume: in press Issue: 3 Pages: 153-154
  • DOI: 10.1016/j.ygyno.2013.03.005
  • Peer Reviewed
• [Journal Article] Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis (2011)
  • Author(s): Ray D, et al
  • Journal Title: Neoplasia Volume: 13 Pages: 439-444
  • Peer Reviewed
• [Journal Article] Prevalence of uterine and adnexal involvement in pulmonary lymphangioleiomyomatosis : a clinicopathologic study of 10 patients (2011)
  • Author(s): Hayashi T, et al
  • Journal Title: Am J Surg Pathol Volume: 35 Pages: 1776-1785
  • Peer Reviewed
• [Journal Article] 化学療法併用放射線療法が奏効した外陰癌の1例 (2011)
  • Author(s): 今井幸, 他
  • Journal Title: 日本産科婦人科学会東京地方部会会誌 Volume: 60 Pages: 56-60
  • Peer Reviewed
• [Journal Article] 子宮内膜症ダグラス窩深部病変から発生したと考えられる腺癌の一例 (2010)
  • Author(s): 寺尾泰久, 須賀新, 楠木総司, 木村美葵, 荻島大貴, 加藤聖子, 竹田省, 正岡亜希子, 樋野興夫, 福村由紀, 八尾隆史
  • Journal Title: 日本産科婦人科学会関東連合地方部会誌 Volume: 47 Pages: 149-156
  • Peer Reviewed
• [Journal Article] Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage. (2010)
  • Author(s): Kato K, Takao T, Kuboyama A, Tanaka Y, Ohgami T, Yamaguchi S, Adachi S, Yoneda T, Ueoka Y, Kato K, Hayashi S, Asanoma K, Wake N.
  • Journal Title: Am J Pathol Volume: 176 Pages: 381-392
  • Peer Reviewed
• [Journal Article] 産婦人科領域における新たな止血法・輸血法Balloon Occlusion法の実際頸部筋腫・巨大子宮筋腫 (2010)
  • Author(s): 寺尾泰久, 山本恵理子, 竹田省
  • Journal Title: 産科と婦人科 Volume: 77 Pages: 675-680
• [Presentation] 早期子宮体癌に対する腹腔鏡下手術の標準化に向けて (2011)
  • Author(s): 寺尾泰久, 他
  • Organizer: 第51回日本産科婦人科内視鏡学会
  • Place of Presentation: 大阪
• [Presentation] 閉経後にエストロゲン高値を示した卵巣上皮性悪性腫瘍の3例 (2011)
  • Author(s): 寺尾泰久, 他
  • Organizer: 第50回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 札幌
• [Presentation] 子宮体癌再発後の治療法の検討 (2010)
  • Author(s): 寺尾泰久, 楠木総司, 木村美葵, 須賀新, 荻島大貴, 加藤聖子, 杉村基, 竹田省
  • Organizer: 第62回日本産科婦人科学会総会
  • Place of Presentation: 東京
• [Presentation] 子宮内膜症ダグラス窩深部病変から発生したと考えられる腺癌の一例 (2010)
  • Author(s): 寺尾泰久, 須賀新, 木村美葵, 楠木総司, 荻島大貴, 加藤聖子, 竹田省
  • Organizer: 第48回日本婦人科腫瘍学会
  • Place of Presentation: 筑波
• [Presentation] 子宮体癌の癌幹細胞形質獲得機構における精巣特異的発現遺伝子dbpC_contrin の関与
  • Author(s): 加藤聖子
  • Organizer: 日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸