Risk factors of associated with hearing impairment : an epidemiological study
| Project/Area Number |
22591873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hirosaki University |
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Principal Investigator |
SHINKAWA Hideichi 弘前大学, 医学(系)研究科(研究院), 教授 (90125584)
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| Co-Investigator(Kenkyū-buntansha) |
KAKEHATA Seiji 弘前大学, 医学(系)研究科(研究院), 准教授 (90261619)
NAMBA Atsushi 弘前大学, 医学部附属病院, 講師 (50361027)
SASAKI Akira 弘前大学, 医学部附属病院, 講師 (20451479)
NAKAJI Shigeyuki 弘前大学, 医学(系)研究科(研究院), 教授 (10192220)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 聴覚障害 / 大規模調査 / アンチエイジング / 動脈硬化 / 遺伝子変異 |
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| Research Abstract |
In this study, we showed that hearing worsens with age, and this was especially obvious in males.
Our results suggested that vascular sclerosis and osteoporosisare risk factors associated with age related hearing impairment. High pulse wave velocity, a parameter of vascular sclerosis, was related to loss of hearing and decreasing of bone mineral density in females also caused hearing impairment.
We confirmed 13 GJB2 gene mutations in this study and also found that 39 of 597 participants (6.53%) were bearers of mutations known to cause hearing impairment.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population2011
Author(s)
Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S, Toh S
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Journal Title
Osteoarthritis Cartilage
Volume: 19
Pages: 51-57
Related Report
Peer Reviewed
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[Journal Article] Knee osteoarthritis, knee joint pain and aging inrelation to increasing serum hyaluronan level in the Japanese population2011
Author(s)
Ryo Inoue, Yasuyuki Ishibashi, Eichi Tsuda, Yuji Yamamoto, Masashi Matsuzaka, Ippei Takahashi, Kazuma Danjo, Takashi Umeda, Shigeyuki Nakaji, Satoshi Toh
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Journal Title
Osteoarthritis and Cartilage
Volume: 19
Pages: 51-57
Related Report
Peer Reviewed
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[Journal Article] Prevalence of metabolic syndrome among patients with schizophrenia in Japan2010
Author(s)
Sugawara N, Yasui-Furukori N, Sato Y, Umeda T, Kishida I, Yamashita H, Saito M, Furukori H, Nakagami T, Hatakeyama M, Nakaji S, Kaneko S.
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Journal Title
Schizophr Res
Volume: 123(2)
Pages: 244-250
Related Report
Peer Reviewed
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[Journal Article] Comparing the influences of age and disease on distortion in the clock drawing test in Japanese patients with schizophrenia2010
Author(s)
Kaneda A, Yasui-Furukori N, Umeda T, Sugawara N, Tsuchimine S, Saito M, Sato Y, Furukori H, Takahashi I, Nakaji S, Kaneko S
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Journal Title
Am J Geriatr Psychiatry
Volume: 18(10)
Pages: 908-916
Related Report
Peer Reviewed
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[Journal Article] Prevalence of metabolic syndrome among patients with schizophrenia in Japan2010
Author(s)
Sugawara N, Yasui-Furukori N, Sato Y, Umeda T, Kishida T, Yamashita H, Saito M, Furukori H, Nakagarai T, Hatakeyama M, Nakaji S, Kaneko S
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Journal Title
Schizophr Res
Volume: 123
Pages: 244-250
Related Report
Peer Reviewed
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[Journal Article] Association between concentration of trace elements in serum and bronchial asthma among Japanese general population2010
Author(s)
Urushidate S, Matsuzaka M, Okubo N, Iwasaki H, Hasebe T, Tsuya R, Iwane K, Inoue R, Yamai K, Danjo K, Takahashi I, Umeda T, Ando S, Itai K, Nakaji S
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Journal Title
J Trace Elem Med Biol
Volume: 24
Pages: 236-242
Related Report
Peer Reviewed
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