| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
To utilize disease-specific iPS cells for the development of novel therapeutics for inner ear diseases, methods for otic induction of iPS cell have been developed, which have high efficiency for induction of hair cell-like cells. We also generated iPS cell lines derived from TRIOBP deficiency mice, and examined their potential for hair cell differentiation. For further progress, a method for induction of mature hair bundles should be established.
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