| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In an aging society, age-related hearing loss is one of the factors to reduce the QOL of the elderly. In the study, we examined gene expression in inner ear of age-related deafness mouse model, as the senescence-associated genes are involved in the development of presbycusis. I was no change in the gene associated with aging in the study using (HSF1-deficient mice, TSOD mouse) mice exhibit symptoms similar to presbycusis. However, the expression of IGF-1 gene decreased in aging TSOD mouse. The expression of the other kinds of gene was changed. We are analyzing the reason for the change of the gene expression after aging.
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