The Change of Heat Shock Response in the Aging Inner Ear
| Project/Area Number |
22591882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 内耳 / 老化 / 熱ショック応答 / 熱ショック蛋白質 |
|---|
| Research Abstract |
In an aging society, age-related hearing loss is one of the factors to reduce the QOL of the elderly. In the study, we examined gene expression in inner ear of age-related deafness mouse model, as the senescence-associated genes are involved in the development of presbycusis. I was no change in the gene associated with aging in the study using (HSF1-deficient mice, TSOD mouse) mice exhibit symptoms similar to presbycusis. However, the expression of IGF-1 gene decreased in aging TSOD mouse. The expression of the other kinds of gene was changed. We are analyzing the reason for the change of the gene expression after aging.
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Report
(4 results)
Research Products
(57 results)
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[Presentation] 老化と聞こえ2012
Author(s)
菅原一真
Organizer
耳の日市民公開講座
Place of Presentation
ニューメディアプラザ山口(山口)(講演)
Year and Date
2012-03-02
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[Presentation] 音響傷害と老人性難聴2010
Author(s)
菅原一真
Organizer
第1回 研究推進体「ストレス」フォーラム
Place of Presentation
山口大学医学部(山口)(講演)
Year and Date
2010-06-15
Related Report
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