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Novel treatment for facial nerve palsy by HSV neuritisUnderstanding its mechanism

Research Project

Project/Area Number 22591886
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagoya City University

Principal Investigator

MURAKAMI Shingo  名古屋市立大学, 大学院・医学研究科, 教授 (80157750)

Co-Investigator(Kenkyū-buntansha) HAMAJIMA Yuki  名古屋市立大学, 大学院・医学研究科, 講師 (30343403)
HIDA Hideki  名古屋市立大学, 大学院・医学研究科, 教授 (00305525)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords耳科学 / 顔面神経麻痺 / Rho / 塩酸ファスジル
Research Abstract

Hepatocyte growth factor (HGF) has been reported to accelerate recovery in central nerve system, but its function in peripheral nerve system is unclear. We transfected HGF using replication-defective herpes simplex virus vector into crushed facial nerve. Recovery from facial nerve palsy was accelerated clinically, electrophysiologically, and pathologically. Transfected cells were detected using immunohistochemicalstaining.Close relationship between HSV and sudden deafness or vestibular neuritis has been reported. We inject HSV-1 or HSV-2 into tympanic cavity of mice. Vertigo and hearing loss was observed in those mice. HSV-infected, apoptotic cells were found in stria vascularis; however, apoptotic cells found around Corti’s organ was not infected with HSV. Apoptosis induction after HSV infection differed according cell types.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Book (1 results)

  • [Journal Article] 勝見さち代:乳幼児の顔面神経麻痺にステロイド薬や手術は必要か2012

    • Author(s)
      村上信五
    • Journal Title

      JOHNS

      Volume: 28(3) Pages: 372-375

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diabetic mice show an aggravated course of herpes-simplex virus-induced facial nerve paralysis.2012

    • Author(s)
      Esaki S
    • Journal Title

      Otology&Neurotology

      Volume: 33(8) Pages: 1452-1457

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 乳幼児の顔面神経麻痺にステロイド薬や手術は必要か?2012

    • Author(s)
      村上 信五
    • Journal Title

      JOHNS

      Volume: 28(3) Pages: 520-521

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 披裂軟骨脱臼7症例の検討と整復術における工夫2012

    • Author(s)
      浅岡恭介
    • Journal Title

      喉頭

      Volume: 24 Pages: 20-24

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 耳科学領域 顔面神経麻痺2011

    • Author(s)
      村上信五
    • Journal Title

      JOHNS

      Volume: 27 Pages: 1360-1362

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 勝見さち代:顔面神経鞘腫のマネジメント側頭骨内顔面神経鞘腫のマネジメント.2010

    • Author(s)
      村上信五,江崎伸一
    • Journal Title

      Facial Nerve Research

      Volume: 29 Pages: 5-7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 勝見さち代:顔面神経麻痺の観血的治療2010

    • Author(s)
      村上信五
    • Journal Title

      ENTONI

      Volume: 111 Pages: 54-66

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Ramsay Hunt症候群の診断と治療―過去、現在、未来―2012

    • Author(s)
      村上 信五
    • Organizer
      第35回日本顔面神経研究会
    • Place of Presentation
      ホテルリステル猪苗代(福島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ベル麻痺・ハント症候群の診断と治療2012

    • Author(s)
      村上 信五
    • Organizer
      第19回ヘルペス感染症フォーラム
    • Place of Presentation
      京王プラザホテル札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中耳・ 内耳画像診断の進歩とピットフォール2012

    • Author(s)
      村上 信五
    • Organizer
      第57回日本聴覚医学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 経中頭蓋窩・聴神経腫瘍摘出術における前庭神経の機能保存2011

    • Author(s)
      村上信五
    • Organizer
      第20回日本聴神経腫瘍研究会.
    • Place of Presentation
      東京
    • Year and Date
      2011-06-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 耳下腺多形線腫の診断にて手術を施行し、術中に顔面神経鞘腫と判明した症例2011

    • Author(s)
      村上信五
    • Organizer
      第34回日本顔面神経研究会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Annual Research Report
  • [Presentation] NIM レスポンスによる減価術・術中顔面神経刺激の有用性と意義2010

    • Author(s)
      村上信五、勝見さち代、江崎伸一、山野耕嗣
    • Organizer
      第33回日本顔面神経研究会.
    • Place of Presentation
      福岡
    • Year and Date
      2010-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 癒着性中耳炎の手術に対する工夫.2010

    • Author(s)
      村上信五
    • Organizer
      第20回日本頭頸部外科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-28
    • Related Report
      2012 Final Research Report
  • [Book] EBM耳鼻咽喉・頭頸部外科の治療2011

    • Author(s)
      村上信五
    • Total Pages
      3
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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