Novel treatment for facial nerve palsy by HSV neuritisUnderstanding its mechanism
| Project/Area Number |
22591886
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagoya City University |
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Principal Investigator |
MURAKAMI Shingo 名古屋市立大学, 大学院・医学研究科, 教授 (80157750)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAJIMA Yuki 名古屋市立大学, 大学院・医学研究科, 講師 (30343403)
HIDA Hideki 名古屋市立大学, 大学院・医学研究科, 教授 (00305525)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 耳科学 / 顔面神経麻痺 / Rho / 塩酸ファスジル |
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| Research Abstract |
Hepatocyte growth factor (HGF) has been reported to accelerate recovery in central nerve system, but its function in peripheral nerve system is unclear. We transfected HGF using replication-defective herpes simplex virus vector into crushed facial nerve. Recovery from facial nerve palsy was accelerated clinically, electrophysiologically, and pathologically. Transfected cells were detected using immunohistochemicalstaining.Close relationship between HSV and sudden deafness or vestibular neuritis has been reported. We inject HSV-1 or HSV-2 into tympanic cavity of mice. Vertigo and hearing loss was observed in those mice. HSV-infected, apoptotic cells were found in stria vascularis; however, apoptotic cells found around Corti’s organ was not infected with HSV. Apoptosis induction after HSV infection differed according cell types.
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Report
(4 results)
Research Products
(15 results)
