Clinical study on efficacy of omalizumab for eosinophilic otitis media

• Project/Area Number: 22591889
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Jichi Medical University
• Principal Investigator: IINO Yukiko 自治医科大学, 医学部, 教授 (30108534)
• Co-Investigator(Kenkyū-buntansha): SHINNABE Akihiro 自治医科大学, 医学部, 助教 (40365367)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 好酸球性中耳炎 / 好酸球性副鼻腔炎 / 気管支喘息 / 抗 IgE 抗体 / オマリズマブ / 中耳貯留液 / 抗IgE抗体

Research Abstract

Eosinophilic otitis media (EOM) is an intractable otitis media and high levels of IgE are detected in the middle ear effusion (MEE). We carried out a study to determine whether anti-IgE therapy is efficacious in the treatment of EOM. Eight patients with E

Research Products

• [Journal Article] Powered endoscopic dacryocystorhinostomy with radiowave instruments:surgical outcomeaccording to obstruction level (2013)
  • Author(s): Yoshida N, Kanazawa H, Shinnabe A, Iino Y.
  • Journal Title: Eur Arch Otorhinolaryngol. Volume: 270(2) Pages: 579-84
• [Journal Article] A Comparison of patterns of Disease Extension in KeratosisObturans and External Auditory Canal Cholesteatoma (2013)
  • Author(s): Shinnabe A,Hara M, Hasegawa M,Matsuzawa S,Kanazawa H, YoshidaN,Iino Y
  • Journal Title: Otol Neurotol Volume: 34(1) Pages: 91-94
• [Journal Article] Differences inmiddle ear ventilation disordersbetween pars flaccida and parsyensa cholesteatoma in sonotubometry and patterns of tympanic and mastoid pneumatization. (2012)
  • Author(s): Shinnabe A,Hara M,Hasegawa M, Matsuzawa S,Kanazawa H,Kanaza T,Yoshida N,Iino Y
  • Journal Title: Otol Neurotol Volume: 33(5) Pages: 765-8
• [Journal Article] Clinical Characteristics and Surgical Benefits and Problems of Chronic Otitis Media and Middle EarCholesteatoma on Elderly Patients Older Than 70 Years (2012)
  • Author(s): Shinnabe A,Hara M,Hasegawa M,Matsuzawa S,Kanazawa H, Yoshida N,Iino Y
  • Journal Title: Otology & Neurotology Volume: 33(7) Pages: 1213-1217
• [Journal Article] Clinical Efficacy of Anti-IgE Therapy for EosinophilicOtitis Media (2012)
  • Author(s): Iino Y,Hara M,Hasegawa M, Matsuzawa S,Shinnabe A, Kanazawa H,Yoshida N
  • Journal Title: Otology & Neurotology Volume: 33(7) Pages: 1218-1224
• [Journal Article] 好酸球性中耳炎の診断と治療-特に局所ステロイドの使い方-. (2012)
  • Author(s): 吉田尚弘、飯野ゆき子
  • Journal Title: Monthly Book ENTONI Volume: 139 Pages: 44-48
• [Journal Article] Clinical Efficacy of Anti-IgE Therapy for Eosinophilic Otitis Media. (2012)
  • Author(s): Iino,Y.
  • Journal Title: Otology & Neurotology. Volume: 33巻 Pages: 1218-1224
  • Peer Reviewed
• [Journal Article] 喘息の修飾因子をめぐって.合併症(1)副鼻腔炎/中耳炎 (2012)
  • Author(s): Iino, Y.
  • Journal Title: 第31回六甲カンファランス Pages: 59-62
• [Journal Article] Diagnostic criteriaof eosinophilic otitis media, anewly recognized middle ear disease (2011)
  • Author(s): Iino Y, et al
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 456-461
• [Journal Article] Clinical practice guidelines for the diagnosis and management of acute otitis media(A0M) in children in Japan (2011)
  • Author(s): Iino Y:
  • Journal Title: AurisNasus Larynx.Epub
• [Journal Article] Diagnostic criteria of eosinophilic otitis media, anewly recognized middleear disease (2011)
  • Author(s): Iino, Y., Tomioka-Matsutani, S., Matsubara, A., Nakagawa, T., Nonaka, M.
  • Journal Title: Auris Nasus Larynx Volume: 38巻 Pages: 456-461
  • Peer Reviewed
• [Journal Article] Clinical practice guidelines for diagnosis and management of acute otitis media(AOM) in children in Japan (2011)
  • Author(s): Iino, Y., et al
  • Journal Title: Auris Nasus Larynx Volume: (Epub.)
  • Peer Reviewed
• [Journal Article] Diagnostic criteria of eosinophilic otitis media, a newly recognized middle ear disease. (2011)
  • Author(s): Iino Y, et al
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 456-461
  • Peer Reviewed
• [Journal Article] 好酸球性中耳炎の臨床 (2011)
  • Author(s): 飯野ゆき子
  • Journal Title: 日本医師会雑誌 Volume: 139 Pages: 2576-2578
• [Journal Article] Role of IgE in eosinophilic otitis media (2010)
  • Author(s): Iino Y
  • Journal Title: Allergol Int Volume: 59 Pages: 233-238
  • NAID: 10029670535
  • Peer Reviewed
• [Presentation] 上気道における好酸球性炎症性疾患のエビデンスと今後の展望 (2013)
  • Author(s): 飯野ゆき子
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 倉敷
• [Presentation] 好酸球性中耳炎における憎悪因子について (2013)
  • Author(s): 金沢弘美,吉田尚弘,飯野ゆき子
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 倉敷
• [Presentation] 上気道における好酸球性炎症性疾患のエビデンスと今後の展望. (2013)
  • Author(s): 飯野ゆき子
  • Organizer: 第31回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 倉敷市
  • Invited
• [Presentation] 好酸球性中耳炎の外来診療 (2012)
  • Author(s): 飯野ゆき子
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 大津市
  • Year and Date: 2012-02-17
• [Presentation] 好酸球性中耳炎の外来 診療 (2012)
  • Author(s): 飯野ゆき子
  • Organizer: 第30回日本耳鼻咽喉科免疫アレルギー学会 ランチョンセミナー
  • Place of Presentation: 滋賀
• [Presentation] 好酸球性中耳炎に対する抗IgE 抗体療法の臨床効果. (2012)
  • Author(s): 飯野ゆき子,金沢弘美,新鍋晶浩, 吉田尚弘
  • Organizer: 第113回 日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 新潟
• [Presentation] Anti-IgE Therapy for EosinophilicOtitis Media. (2012)
  • Author(s): Iino Y,Kanazawa H,Yoshida N
  • Organizer: The First Asian Otology Meeting & The 3rd East AsianSymposium on Otology
  • Place of Presentation: Nagasaki
• [Presentation] Clinical Characteristicsof the Secondary Cholesteatoma ofthe Middle Ear. (2012)
  • Author(s): Kanazawa H,Shinnabe A,Yoshida N, Iino,Y.
  • Organizer: The First AsianOtology Meeting & The 3rd East Asian Symposium on Otology
  • Place of Presentation: Nagasaki
• [Presentation] Eosinophillc Otitis Media. (2012)
  • Author(s): Iino Y
  • Organizer: The 9th international Conference on Cholesteatoma and Ear Surgery,Panel Discussion 11,Moderator
  • Place of Presentation: Nagasaki
• [Presentation] シンポジウム 14. 難治性アレルギー性疾患に対するアプローチ.好酸球性中耳炎の診断と治療 (2012)
  • Author(s): 飯野ゆき子
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪市
• [Presentation] 好酸球性中耳炎に対する抗IgE抗体療法の臨床効果. (2012)
  • Author(s): 飯野ゆき子
  • Organizer: 第113回 日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 新潟市
• [Presentation] Anti-IgE Therapy for Eosinophilic Otitis Media. (2012)
  • Author(s): Iino,Y.
  • Organizer: The First Asian Otology Meeting & The 3rd East Asian Symposium on Otology.
  • Place of Presentation: Nagasaki
  • Invited
• [Presentation] Eosinophillc Otitis Media. (2012)
  • Author(s): Iino,Y.
  • Organizer: The 9th international Conference on Cholesteatoma and Ear Surgery.
  • Place of Presentation: Nagasaki
  • Invited
• [Presentation] 難治性アレルギー性疾患に対するアプローチ 好酸球性中耳炎の診断と治療. (2012)
  • Author(s): 飯野ゆき子
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪市
  • Invited
• [Presentation] Role of IgE in Eosinophilic Otitis Media (2011)
  • Author(s): Iino, Y., Yoshida, N., Kanazawa, H.
  • Organizer: 11^<th> Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery, Symposium
  • Place of Presentation: 神戸市
  • Year and Date: 2011-12-09
• [Presentation] 好酸球性中耳炎の診断と治療 (2011)
  • Author(s): 飯野ゆき子
  • Organizer: 第21回日本耳科学会総会学術講演会ランチョンセミナー4
  • Place of Presentation: 沖縄
  • Year and Date: 2011-11-25
• [Presentation] 好酸球性中耳炎の診断と治療 (2011)
  • Author(s): 飯野ゆき子
  • Organizer: 第21回日本耳科学会総会学術講演会
  • Place of Presentation: 宜野湾市
  • Year and Date: 2011-11-25
• [Presentation] 好酸球性中耳炎治療-最新の話題- (2011)
  • Author(s): 飯野ゆき子
  • Organizer: 第29回呼吸器・免疫シンポジウム
  • Place of Presentation: 東京都
  • Year and Date: 2011-10-01
• [Presentation] Effectiveness of Macrolide Therapy for Chronic Rhinosinusitis (2011)
  • Author(s): Iino, Y.
  • Organizer: IRS (14^<th> International Rhinologic Society) ISIAN (30^<th> International Symposium on Infection and Allergy of the Nose)
  • Place of Presentation: 東京都
  • Year and Date: 2011-09-22
• [Presentation] Effectiveness of Macrolide Therapy for ChronicRhinosinusitis. (2011)
  • Author(s): Iino Y
  • Organizer: IRS & ISIAN 2011
  • Place of Presentation: Japan
• [Presentation] Role of IgE in Eosinophilic OtitisMedia. (2011)
  • Author(s): Iino Y,Yoshida N,Kanazawa H
  • Organizer: 11thJapan-Taiwan Conference on Otolaryngology-Head andNeck Surgery,Symposium11-4
  • Place of Presentation: Japan
• [Presentation] Clinical characteristics and pathogenesis of eosinophilic otitis media. (2010)
  • Author(s): Iino Y
  • Organizer: the 7^<th> International Symposium on Tonsils and Mucosal Barriers of the Upper Airways
  • Place of Presentation: Asahikawa
• [Remarks] に研究業績を発表
  • URL: http://www.jichi.ac.jp/saitama-jibika/index.html