| Project/Area Number |
22591890
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
SUZUKI Mamoru 東京医科大学, 医学部, 教授 (80116607)
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Taro 東京医科大学, 医学部, 講師 (80366103)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | めまい / クプラ / 半規管 / 形態異常 / 内耳障害 / 感覚上皮障害 / 血流障害 / 前庭動脈 / 末梢性めまい / ゲンタマイシン / 温度眼振反応 / 活動電位 / 電子顕微鏡 |
|---|
| Research Abstract |
Insults, such as injection of the ototoxic drugs, rupture of the membranous labyrinth and occlusion of the vestibular artery resulted in various degrees of the cupularshrinkage. Particularly, artery occlusion caused the rapid and severe changes. The sensory epithelial change developed earlier than that of the cupula. These results indicate that the cupular change can be a cause of vertigo and circulation disorder induces acute and severe vertigo. For the cases with high risk circulation disorder, circulation should be improved as early as possible. When drug treatment is not effective, early rehabilitation is recommended.
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