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Sublingual immunotherapy for pediatric cedar pollinosis and its mechanism by inducible regulatory T cells and IgG4.

Research Project

Project/Area Number 22591897
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionMie University

Principal Investigator

YUTA Atsushi  三重大学, 大学院・医学系研究科, リサーチアソシエイト (80293778)

Co-Investigator(Kenkyū-buntansha) ISHINAGA Hajime  三重大学, 医学部附属病院, 講師 (50335121)
YAMANAKA Kei Ichi  三重大学, 大学院・医学系研究科, 准教授 (70314135)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords鼻科学 / 舌下免疫療法 / スギ花粉症 / 制御性T細胞 / IgG4 / 小児 / IL-33 / 制御性細胞
Research Abstract

We began sublingual immunotherapy (SLIT) for pediatric cedar pollinosis as a first clinical trial in Japan. SLIT is effective and safe even in Children, and its efficacy in children is better than that in adults. We found some problems from this study. Especially , we found that SLIT in about a half of for cypress pollinosis patients is not effective, even if it is effective for cedar pollinosis.We also studied immunological changes by SLIT. The results were increased inducible regulatory T cells, increased cedar pollen-specific IgG4 in the responder group for SLIT, increased serum IL-33 in the non-responder group for SLIT, and no changes of serum IL-31 or IL17A.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Book (2 results) Remarks (2 results)

  • [Journal Article] スギ花粉症の舌下免疫療法2013

    • Author(s)
      湯田厚司、小川由起子
    • Journal Title

      日本医師会雑誌

      Volume: 141 Pages: 2180-2180

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] 免疫療法2013

    • Author(s)
      湯田厚司
    • Journal Title

      JOHNS

      Volume: 29 Pages: 622-626

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] et al Therapeutic outcomes and immunological effects of sublingual immunotherapy for Japanese cedar pollinosis2012

    • Author(s)
      Yuta A、Ogihara H、Yamanaka K
    • Journal Title

      Clinical Experimental Allergy Review

      Volume: 12 Pages: 29-35

    • Related Report
      2012 Final Research Report
  • [Journal Article] スギ花粉症の舌下免疫はどの程度有効か2012

    • Author(s)
      湯田厚司、小川由起子
    • Journal Title

      JOHNS

      Volume: 29 Pages: 73-76

    • Related Report
      2012 Final Research Report
  • [Journal Article] Therapeutic outcomes and immunological effects of sublingual immunotherapy for Japanese cedar pollinosis2012

    • Author(s)
      Yuta A
    • Journal Title

      Clinical Experimental Allergy Review

      Volume: 12 Pages: 29-35

    • Related Report
      2012 Annual Research Report
  • [Journal Article] et al、SLIT improves cedar pollinosis by restoring IL-10 production from Tr1 and monocyte~IL-10 productivity is critical for becoming allergic~2011

    • Author(s)
      Yamanaka Y、Yuta A
    • Journal Title

      Allergology international

      Volume: 60 Pages: 45-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児スギ花粉症に対する舌下免疫療法2011

    • Author(s)
      湯田厚司
    • Journal Title

      東海花粉症研究会誌

      Volume: 22 Pages: 33-38

    • Related Report
      2012 Final Research Report
  • [Journal Article] SLIT improves cedar pollinosis by restoring IL-10 production from Tr1 and monocyte~IL-10 productivity is critical for becoming allergic~2011

    • Author(s)
      Yamanaka Y
    • Journal Title

      Allergology international

      Volume: 60 Pages: 45-51

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児スギ花粉症に対する舌下免疫療法2011

    • Author(s)
      湯田厚司
    • Journal Title

      東海花粉症研究会

      Volume: 22 Pages: 33-38

    • Related Report
      2011 Annual Research Report
  • [Presentation] 小児スギ花粉症の舌下免疫療法~大量飛散年の検討~2011

    • Author(s)
      湯田厚司
    • Organizer
      第50回日本鼻科学会
    • Place of Presentation
      岡山市
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 小児スギ花粉症の舌下免疫療法2011

    • Author(s)
      湯田厚司
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 急増するスギ花粉症の問題点と舌下免疫療法への期待と課題2011

    • Author(s)
      湯田厚司
    • Organizer
      第62回中部皮膚科学会中部支部学術講演会
    • Place of Presentation
      四日市市
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 急増するスギ花粉症の問題点と舌下免疫療法への期待と課題2011

    • Author(s)
      湯田厚司
    • Organizer
      第62回中部皮膚科学会中部支部学術講演会
    • Place of Presentation
      四日市市(招待講演)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Book] 日経ドラッグインフォメーション2013

    • Author(s)
      湯田厚司
    • Publisher
      日経BP社
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Book] チャイルドヘルス2012

    • Author(s)
      湯田厚司
    • Publisher
      診断と治療社
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Remarks] 2010年度の公開

    • URL

      http://www.medic.mie-u.ac.jp/kafun/

    • Related Report
      2012 Final Research Report
  • [Remarks] 2011年度からサーバー変更

    • URL

      http://www.kafun-mie.expressweb.jp/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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