Sublingual immunotherapy for pediatric cedar pollinosis and its mechanism by inducible regulatory T cells and IgG4.
| Project/Area Number |
22591897
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Mie University |
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Principal Investigator |
YUTA Atsushi 三重大学, 大学院・医学系研究科, リサーチアソシエイト (80293778)
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| Co-Investigator(Kenkyū-buntansha) |
ISHINAGA Hajime 三重大学, 医学部附属病院, 講師 (50335121)
YAMANAKA Kei Ichi 三重大学, 大学院・医学系研究科, 准教授 (70314135)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 鼻科学 / 舌下免疫療法 / スギ花粉症 / 制御性T細胞 / IgG4 / 小児 / IL-33 / 制御性細胞 |
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| Research Abstract |
We began sublingual immunotherapy (SLIT) for pediatric cedar pollinosis as a first clinical trial in Japan. SLIT is effective and safe even in Children, and its efficacy in children is better than that in adults. We found some problems from this study. Especially , we found that SLIT in about a half of for cypress pollinosis patients is not effective, even if it is effective for cedar pollinosis.We also studied immunological changes by SLIT. The results were increased inducible regulatory T cells, increased cedar pollen-specific IgG4 in the responder group for SLIT, increased serum IL-33 in the non-responder group for SLIT, and no changes of serum IL-31 or IL17A.
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Report
(4 results)
Research Products
(17 results)
