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Elucidation and control of mechanisms of mucus hypersecretion in the intractable upper airway diseases

Research Project

Project/Area Number 22591899
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionMie University

Principal Investigator

TAKEUCHI Kazuhiko  三重大学, 大学院・医学系研究科, 教授 (50206942)

Co-Investigator(Kenkyū-buntansha) ISHINAGA Hajime  三重大学, 医学部附属病院, 講師 (50335121)
SAKAIDA Hiroshi  三重大学, 大学院・医学系研究科, 助教 (30378426)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords鼻科学 / ムチン遺伝子 / アレルギー性炎症 / 好酸球性副鼻腔炎 / TGF-α / TNF-α / MUC5AC / マクロライド / デキサメサゾン / 好酸球 / 副鼻腔炎 / ムチン / 粘液 / エンテロトキシン / NF-kB
Research Abstract

TGF-α immunoreactivity was found markedly increased in the submucosal tissue in the eosinophilic chronic rhinosinusitis patient compared with that of a normal patient and with noneosinophilic chronic rhinosinusitis. TGF-α synergized with TNF-α to upregulate MUC5AC expression in human epithelial cells through the ERK signaling pathway. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. These findings suggest that IL-31 plays an important role in mucus overproduction in nasal allergic inflammation. A new erythromycin derivative, EM900, does not have antibacterial action.EM900 suppressed induction of inflammatory cytokines and MUC5AC gene expression in cells derived from human airway epithelia, and our findings indicated that these effects may be mediated by the suppression of NF-κB activation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] Effects of Interleukin-31 onMUC5AC Gene Expression in Nasal2013

    • Author(s)
      Shah SA, Ishinaga H, Hou B, Okano M, Takeuchi K.
    • Journal Title

      Allergic Inflammation. Pharmacology

      Volume: 91 Pages: 158-164

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Interleukin-31 on MUC5AC Gene Expression in Nasal Allergic Inflammation.2013

    • Author(s)
      Said Ahamad Shah
    • Journal Title

      Pharmacology

      Volume: 91 Pages: 158-164

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line.2011

    • Author(s)
      Otsu K, Ishinaga H, Suzuki S, Sugawara A, Sunazuka T, Omura S, Jono H, Takeuchi K.
    • Journal Title

      Pharmacology

      Volume: 88 Issue: 5-6 Pages: 327-32

    • DOI

      10.1159/000334339

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of transforming growth factor-α on mucin overproduction in eosinophilic chronic rhinosinusitis2011

    • Author(s)
      Ishinaga H, Shah SA, Sakaida H,Takeuchi K
    • Journal Title

      Pharmacology

      Volume: 88 Issue: 5-6 Pages: 302-8

    • DOI

      10.1159/000333794

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea2011

    • Author(s)
      Kitano M, Ishinaga H, Shimizu T, Takeuchi K, Majima Y
    • Journal Title

      Pharmacology.

      Volume: 87 Issue: 1-2 Pages: 56-62

    • DOI

      10.1159/000322837

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of clarithromycin and dexamethasone on mucus production in isografted rat trachea2011

    • Author(s)
      Kitano M, Ishinaga H, et al.
    • Journal Title

      Pharmacology

      Volume: 87 Pages: 56-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト気道上皮でのムチン遺伝子発現に対するIL-31 の影響Source2012

    • Author(s)
      石永 一,竹内 万彦
    • Organizer
      第29回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Year and Date
      2012-02-17
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト気道上皮でのムチン遺伝子発現に対するIL-31の影響2012

    • Author(s)
      石永一、竹内万彦
    • Organizer
      第30回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津、滋賀県
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Two cases of Kartagener's syndrome2011

    • Author(s)
      Sakaida H, Sakaida M, Shibata T, Ogawa S, Nakatani K, Takeuchi K
    • Organizer
      30thinternational symposium on infection and allergy of the nose
    • Place of Presentation
      To kyo
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of EM900 on cytokine and mucin gene expression in a human airway epithelial cell line2011

    • Author(s)
      Ishinaga H, Otsu K, Sakaida H, Takeuchi K
    • Organizer
      30thinternational symposium on infection and allergy of the nose
    • Place of Presentation
      To kyo
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Mucosal barrier function in allergic rhinitis2011

    • Author(s)
      Takeuchi K.
    • Organizer
      Mucosal barrier function in allergic rhinitis
    • Place of Presentation
      To kyo
    • Year and Date
      2011-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Recent advances in primary ciliary dyskinesia2011

    • Author(s)
      Takeuchi K
    • Organizer
      30thinternational symposium on infection and allergy of the nose
    • Place of Presentation
      To kyo
    • Year and Date
      2011-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 難治性上気道疾患への取り組み2011

    • Author(s)
      竹内万彦
    • Organizer
      日本耳鼻咽喉科学会福井県地方部会
    • Place of Presentation
      福井市
    • Year and Date
      2011-06-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 原発性線毛運動不全の一例2010

    • Author(s)
      竹内万彦、小川覚、中谷中、細木興亜、藤澤隆夫
    • Organizer
      第5回日本小児耳鼻咽喉科学会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-27
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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