Elucidation and control of mechanisms of mucus hypersecretion in the intractable upper airway diseases
Project/Area Number |
22591899
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
ISHINAGA Hajime 三重大学, 医学部附属病院, 講師 (50335121)
SAKAIDA Hiroshi 三重大学, 大学院・医学系研究科, 助教 (30378426)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 鼻科学 / ムチン遺伝子 / アレルギー性炎症 / 好酸球性副鼻腔炎 / TGF-α / TNF-α / MUC5AC / マクロライド / デキサメサゾン / 好酸球 / 副鼻腔炎 / ムチン / 粘液 / エンテロトキシン / NF-kB |
Research Abstract |
TGF-α immunoreactivity was found markedly increased in the submucosal tissue in the eosinophilic chronic rhinosinusitis patient compared with that of a normal patient and with noneosinophilic chronic rhinosinusitis. TGF-α synergized with TNF-α to upregulate MUC5AC expression in human epithelial cells through the ERK signaling pathway. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. These findings suggest that IL-31 plays an important role in mucus overproduction in nasal allergic inflammation. A new erythromycin derivative, EM900, does not have antibacterial action.EM900 suppressed induction of inflammatory cytokines and MUC5AC gene expression in cells derived from human airway epithelia, and our findings indicated that these effects may be mediated by the suppression of NF-κB activation.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] Two cases of Kartagener's syndrome2011
Author(s)
Sakaida H, Sakaida M, Shibata T, Ogawa S, Nakatani K, Takeuchi K
Organizer
30thinternational symposium on infection and allergy of the nose
Place of Presentation
To kyo
Year and Date
2011-09-22
Related Report
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