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Elucidation of the pathogenesis and the onset of eosinophilic rhinosinusitis by airborne microorganisms (fungi, Staphylococcus aureus)

Research Project

Project/Area Number 22591904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionJikei University School of Medicine

Principal Investigator

MATSUWAKI Yoshinori  東京慈恵会医科大学, 医学部, 耳鼻咽喉科 (60287290)

Co-Investigator(Kenkyū-buntansha) OKUSHI Tetsushi  東京慈恵会医科大学, 医学部・耳鼻咽喉科 (50317939)
NAKAYAMA Tsuguhisa  東京慈恵会医科大学, 医学部・耳鼻咽喉科 (50408431)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords鼻副鼻腔炎 / 好酸球 / 真菌 / スーパー抗原 / 好酸球性鼻副鼻腔炎 / アレルギー性真菌性鼻副鼻腔炎 / 好酸球性副鼻腔炎 / アレルギー性真菌性副鼻腔炎 / IgE / 鼻茸 / 好酸球炎症 / 黄色ブドウ球菌エンテロトキシン / xylanase / alternaria / アレルギー / サイトカイン / 気道上皮 / 慢性鼻副鼻腔炎 / プロテアーゼ / 黄色ブドウ球菌 / アレルギー性真菌性鼻副鼻腔
Research Abstract

In our clinical study, we found that local total IgE and antigen (fungi, mites and SEs)-specific IgEs in nasal polyps are related to local eosinophilic inflammation of CRSwNP and AFRS. In our vitro study, we also found that Aspartate proteases from Alternariainduce cytokine production and calcium responsein airway epithelium that is mediated through PAR-2.. Furthermore, we also found that both the epithelium and the infiltrating eosinophils in the ECRS showed significant upregulation of the expression of PAR-2.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (83 results)

All 2013 2012 2011 2010 Other

All Journal Article (38 results) (of which Peer Reviewed: 25 results) Presentation (42 results) (of which Invited: 2 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Total and antigen- (fungi, mites and staphylococcal enterotoxins) specific iges in nasal polyps is related to local eosinophilic inflammation2013

    • Author(s)
      Matsuwaki Y, Uno K, Okushi T, Otori N, Moriyama H
    • Journal Title

      Int Arch Allergy Immunol 161 Suppl

      Volume: 2 Issue: Suppl. 2 Pages: 147-153

    • DOI

      10.1159/000350387

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of protease-activated receptors in chronic rhinosinusitis.2013

    • Author(s)
      Yoshida T, Matsuwaki Y, Asaka D, Hama T, Otori N, Moriyama H
    • Journal Title

      Int Arch Allergy Immunol 161 Suppl

      Volume: 2 Issue: Suppl. 2 Pages: 138-146

    • DOI

      10.1159/000350386

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alternaria inhibits double-stranded rna-induced cytokine production through toll-like receptor 3.2013

    • Author(s)
      Wada K, Kobayashi T, Matsuwaki Y, Moriyama H, Kita H
    • Journal Title

      Int Arch Allergy Immunol 161 Suppl

      Volume: 2 Issue: Suppl. 2 Pages: 75-83

    • DOI

      10.1159/000350365

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for olfactory dysfunction in chronic rhinosinusitis2013

    • Author(s)
      Mori E, Matsuwaki Y,Mitsuyama C, Okushi T, Nakajima T, Moriyama H
    • Journal Title

      Auris Nasus Larynx

      Volume: 40 Issue: 5 Pages: 465-469

    • DOI

      10.1016/j.anl.2012.12.005

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alternaria fungus induces the production of GM-CSF, Interleukin-6 and Interleukin-8 and calcium signaling in human airway epithelium through protease-activatedreceptor 22012

    • Author(s)
      Matsuwaki Y, Wada K, White T, Moriyama H, Kita H
    • Journal Title

      Int Arch Allergy Immunol 158 Suppl

      Volume: 1 Issue: Suppl. 1 Pages: 19-29

    • DOI

      10.1159/000337756

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー性真菌性鼻副鼻腔炎(AFRS)について2012

    • Author(s)
      松脇由典
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 115 Pages: 646-647

    • NAID

      10030800067

    • URL

      http://search.jamas.or.jp/link/ui/M627480007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] 好酸球性副鼻腔炎の手術療法と術後治療2012

    • Author(s)
      松脇 由典
    • Journal Title

      日本鼻科学会会誌

      Volume: 51 Pages: 48-50

    • NAID

      130004546118

    • URL

      http://search.jamas.or.jp/link/ui/MC28470012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] アレルギーに関する画像とその解説 アレルギー性真菌性鼻副鼻腔炎の画像所見2012

    • Author(s)
      松脇由典
    • Journal Title

      アレルギー・免疫

      Volume: 19 Pages: 614-623

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Fungus, Alternaria, induces GM-CSF, IL-6, and IL-8 production and calcium signaling in human airway epithelium through protease-activated receptor-22012

    • Author(s)
      Yoshinori Matsuwaki
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 158 Pages: 19-29

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of symptoms and QOL with calcium alginate versus chitincoated gauze for middle meatus packing after endoscopic sinus surgery2012

    • Author(s)
      Okushi Tetsushi
    • Journal Title

      Auris Nasus Larynx

      Volume: 39 Issue: 1 Pages: 31-37

    • DOI

      10.1016/j.anl.2011.02.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for complications of endoscopic sinus surgery for chronic rhinosinusitis2012

    • Author(s)
      Asaka Daiya
    • Journal Title

      Am J Rhinol Allergy

      Volume: 26 Issue: 1 Pages: 61-64

    • DOI

      10.2500/ajra.2012.26.3711

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of residual ethmoid cells on postoperative course after endoscopic sinus surgery for chronic rhinosinusitis2012

    • Author(s)
      Okushi Tetsushi
    • Journal Title

      Auris Nasus Larynx

      Volume: 39 Issue: 5 Pages: 484-489

    • DOI

      10.1016/j.anl.2011.09.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cockroach induces inflammatory responses through protease-dependent pathways.2011

    • Author(s)
      Wada K, Matsuwaki Y, Moriyama H, Kita H
    • Journal Title

      Int Arch Allergy Immunol 155 Suppl

      Volume: 1 Issue: Suppl. 1 Pages: 135-141

    • DOI

      10.1159/000327500

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human eosinophil innate response to alternaria fungus through protease-activated receptor-22011

    • Author(s)
      Matsuwaki Y, Wada K, Moriyama H, Kita H
    • Journal Title

      Int Arch Allergy Immunol 155 Suppl

      Volume: 1 Issue: Suppl. 1 Pages: 123-128

    • DOI

      10.1159/000327498

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 好酸球性鼻副鼻腔炎のct画像診断の検討2011

    • Author(s)
      荻野展広, 松脇由典, 尾尻博也, 狩野麻美, 福田国彦
    • Journal Title

      臨床放射線査読有り

      Volume: 56 Pages: 758-762

    • URL

      http://search.jamas.or.jp/link/ui/2011279324

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mucosal eosinophilia and recurrence of nasal polyps-new classification of chronic rhinosinusitis2011

    • Author(s)
      Nakayama Tsuguhisa
    • Journal Title

      Rhinology

      Volume: 49 Issue: 4 Pages: 392-396

    • DOI

      10.4193/rhino10.261

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カード型嗅覚同定能検査と基準嗅力検査および静脈性嗅覚検査の比較検討2011

    • Author(s)
      森恵莉
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 114 Pages: 917-923

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鼻茸中の真菌および黄色ブドウ球菌由来エンテロトキシン特異的IgE抗体の役割2011

    • Author(s)
      松脇由典
    • Journal Title

      耳鼻咽喉科免疫アレルギー

      Volume: 29 Pages: 55-56

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 【慢性炎症の病態を理解する】慢性炎症の概念と病態急性炎症の遷延化について2011

    • Author(s)
      松脇由典
    • Journal Title

      JOHNS

      Volume: 27 Pages: 1699-1704

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 真菌性副鼻腔炎2011

    • Author(s)
      松脇由典
    • Journal Title

      JOHNS

      Volume: 27 Pages: 1384-1385

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 【慢性副鼻腔炎の病態と気道・中耳疾患】それぞれの慢性鼻副鼻腔炎治療.アレルギー2011

    • Author(s)
      松脇由典
    • Journal Title

      アレルギー・免疫

      Volume: 18 Pages: 1659-1665

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 2011年花粉症の季節を迎えて花粉症治療のポイントを探る2011

    • Author(s)
      今井透
    • Journal Title

      鼻アレルギーフロンティア

      Volume: 11 Pages: 56-65

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 好酸球性副鼻腔炎における再手術後の自覚症状についての検討2011

    • Author(s)
      吉川衛
    • Journal Title

      耳鼻咽喉科展望

      Volume: 54 Pages: 140-145

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 好酸球性鼻副鼻腔炎のCT画像診断の検討2011

    • Author(s)
      荻野展広
    • Journal Title

      臨床放射線

      Volume: 56 Pages: 758-762

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of intraoperative CT-updates during image-guided endoscopic sinus surgery for sinonasal fibro-osseous lesions2011

    • Author(s)
      Wong WK
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Issue: 5 Pages: 628-631

    • DOI

      10.1016/j.anl.2010.11.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of sphenoid sinus meningoencephalocele repaired by an image-guided endoscopic endonasal approach2011

    • Author(s)
      Sano Hiromi
    • Journal Title

      Auris Nasus Larynx

      Volume: 38 Issue: 5 Pages: 632-637

    • DOI

      10.1016/j.anl.2011.01.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human Eosinophil Innate Response to Alternaria Fungus through Protease-Activated Receptor-22011

    • Author(s)
      Yoshinori Matsuwaki
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155 Pages: 123-128

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cockroach Induces Inflammatory Responses through Protease-DependentPathways2011

    • Author(s)
      Kota Wada
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 155 Pages: 135-141

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of sphenoid sinus meningoencephalocele repaired by an image-guided endoscopic endonasal approach2011

    • Author(s)
      Hiromi Sano
    • Journal Title

      Auris Nasus Larynx.

      Volume: 38 Pages: 632-637

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of intraoperative CT-updates during image-guided endoscopic sinus surgery for sinonasal fibro-osseous lesions2011

    • Author(s)
      Justin Wai Wong
    • Journal Title

      Auris Nasus Larynx.

      Volume: 38 Pages: 628-631

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory responses of human eosinophils to cockroach are mediated through protease-dependent pathways2010

    • Author(s)
      Wada K, Matsuwaki Y, Yoon J, Benson LM, Checkel JL, Bingemann TA, Kita H
    • Journal Title

      J Allergy Clin Immunol

      Volume: 126 Issue: 1 Pages: 169-172

    • DOI

      10.1016/j.jaci.2010.04.007

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Progress in endoscopic sinus surgery2010

    • Author(s)
      Yoshinori Matsuwaki
    • Journal Title

      Nippon Rinsho

      Volume: 68 Pages: 1360-1365

    • NAID

      40017192435

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 鼻性髄液漏の診断と治療2010

    • Author(s)
      松脇由典
    • Journal Title

      耳鼻咽喉科展望

      Volume: 53 Pages: 300-310

    • NAID

      130004546297

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 内視鏡下鼻副鼻腔手術術後の自覚症状、QOL変化について2010

    • Author(s)
      吉田拓人
    • Journal Title

      耳鼻咽喉科展望

      Volume: 53 Pages: 293-299

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アレルギー性真菌性鼻副鼻腔炎-Allergic fungal rhinosinusitis(AFRS)2010

    • Author(s)
      松脇由典
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 436-444

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 急性鼻副鼻腔炎、鼻茸に対する鼻噴霧用ステロイド薬の効果2010

    • Author(s)
      松脇由典
    • Journal Title

      アレルギーの臨床

      Volume: 11 Pages: 997-1001

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 好酸球性副鼻腔炎・アレルギー性真菌性副鼻腔炎の病理像2010

    • Author(s)
      松脇由典
    • Journal Title

      アレルギー・免疫

      Volume: 17 Pages: 822-831

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 髄液漏患者への脂肪組織充填2010

    • Author(s)
      松脇由典
    • Journal Title

      日本医事新報

      Volume: 4511 Pages: 81-82

    • Related Report
      2010 Annual Research Report
  • [Presentation] 鼻茸中の真菌および黄色ブドウ球菌由来エンテロトキシン特異的 IgE 抗体の役割について.2012

    • Author(s)
      松脇由典
    • Organizer
      好酸球・アレルギー研究会.
    • Place of Presentation
      大手町サンケイビル(東京)
    • Year and Date
      2012-06-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 鼻茸中の真菌アレルゲン特異的 IgE 抗体の役割について2012

    • Author(s)
      松脇由典
    • Organizer
      第43回日本職業・環境アレルギー学会(招待講演)
    • Place of Presentation
      一ツ橋記念講堂(東京)
    • Year and Date
      2012-06-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 環境微生物由来糖鎖分解酵素XylanaseはProtease Activated Receptor-2を介しヒト分離好酸球の活性化および脱顆粒を誘導する.2012

    • Author(s)
      松脇由典
    • Organizer
      耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Year and Date
      2012-02-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 環境微生物由来糖鎖分解酵素XylanaseはProtease Activated Receptor-2を介しヒト分離好酸球の活性化および脱顆粒を誘導する2012

    • Author(s)
      松脇由典
    • Organizer
      耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      大津市
    • Year and Date
      2012-02-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 好酸球性鼻副鼻腔炎の病態と診断・治療.2012

    • Author(s)
      松脇由典
    • Organizer
      第12回日耳鼻東京都地方部会医療研究会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2012-02-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 第19回日本鼻科学会賞受賞記念講演 真菌 Alternaria による好酸球炎症2012

    • Author(s)
      松脇由典
    • Organizer
      日本鼻科学会総会・学術講演会(招待講演)
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Final Research Report
  • [Presentation] 環境微生物由来糖鎖分解酵素 Xylanase は PAR-2 を介しヒト好酸球の活性化および脱顆粒を誘導する2012

    • Author(s)
      松脇由典
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 鼻茸中の真菌アレルゲン特異的IgE抗体の役割について2012

    • Author(s)
      松脇由典
    • Organizer
      第43回日本職業・環境アレルギー学会
    • Place of Presentation
      一ツ橋記念講堂
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 鼻茸中の真菌および黄色ブドウ球菌由来エンテロトキシン特異的IgE抗体の役割について2012

    • Author(s)
      松脇由典
    • Organizer
      好酸球・アレルギー研究会
    • Place of Presentation
      大手町サンケイビル
    • Related Report
      2012 Annual Research Report
  • [Presentation] 第19回日本鼻科学会賞受賞記念講演 真菌Alternariaによる好酸球炎症2012

    • Author(s)
      松脇由典
    • Organizer
      日本鼻科学会総会・学術講演会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環境微生物由来糖鎖分解酵素XylanaseはPAR-2を介しヒト好酸球の活性化および脱顆粒を誘導する2012

    • Author(s)
      松脇由典
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of Intraoperative CT-updates During Image-guided Endoscopic Endonasal Surgery (IGESS)2011

    • Author(s)
      Yoshinori Matsuwaki
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery(招待講演)
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2011-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of Intraoperative CT-updates During Image-guided Endoscopic Endonasal Surgery (IGESS)2011

    • Author(s)
      Yoshinori Matsuwaki
    • Organizer
      11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kobe, Japan(招待講演)
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性鼻副鼻腔炎における嗅覚障害-嗅覚障害罹病期間とその予後について-2011

    • Author(s)
      松脇由典
    • Organizer
      日本鼻科学会
    • Place of Presentation
      岡山市
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 好酸球性副鼻腔炎の診断および評価基準作成の試み-好酸球性鼻副鼻腔炎の手術療法と保存的治療-2011

    • Author(s)
      松脇由典
    • Organizer
      日本鼻科学会 第47回鼻科学臨床問題懇話会(招待講演)
    • Place of Presentation
      岡山市
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 好酸球性副鼻腔炎の診断および評価基準作成の試み-好酸球性鼻副鼻腔炎の手術療法と保存的治療-2011

    • Author(s)
      松脇由典
    • Organizer
      日本鼻科学会第47回鼻科学臨床問題懇話会
    • Place of Presentation
      岡山市(招待講演)
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性鼻副鼻腔炎における嗅覚障害-嗅覚障害罹病期間とその予後について-Olfactory impairment in chronic rhinosinusitis - Prognosis and duration of hyposmia -2011

    • Author(s)
      松脇由典
    • Organizer
      味と匂い学会
    • Place of Presentation
      金沢市
    • Year and Date
      2011-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性鼻副鼻腔炎における嗅覚障害-嗅覚障害罹病期間とその予後について-Olfactory impairment in chronic rhinosinusitis-Prognosis and duration of hyposmia-2011

    • Author(s)
      松脇由典
    • Organizer
      味と匂い学会
    • Place of Presentation
      金沢市
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Differences and similarities between Western countries and Japan in Eosinophilic Rhinosinusitis.2011

    • Author(s)
      Yoshinori Matsuwaki
    • Organizer
      14th IRS & 30th ISIAN(招待講演)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2011-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Differences and similarities between Western countries and Japan in Eosinophilic Rhinosinusitis2011

    • Author(s)
      Yoshinori Matsuwaki
    • Organizer
      14th IRS & 30th ISIAN
    • Place of Presentation
      Tokyo, Japan(招待講演)
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 真菌Alternariaによるヒト気道上皮細胞のサイトカイン・ケモカイン産生および細胞.2011

    • Author(s)
      松脇由典
    • Organizer
      アレルギー・好酸球研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 真菌Alternariaによるヒト気道上皮細胞のサイトカイン・ケモカイン産生および細胞2011

    • Author(s)
      松脇由典
    • Organizer
      アレルギー・好酸球研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 好酸球性鼻副鼻腔炎の病態と診断・治療2011

    • Author(s)
      松脇由典
    • Organizer
      第12回日耳鼻東京都地方部会医療研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-02-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of Local Immunoglobulin E Production in the Pathophysiology of Chronic Rhinosinusitis with Nasal Polyps and Allergic Fungal Rhinosinusitis.2011

    • Author(s)
      Yoshinori Matsuwaki
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of Local Immunoglobulin E Production in the Pathophysiology of Chronic Rhinosinusitis with Nasal Polyps and Allergic Fungal Rhinosinusitis2011

    • Author(s)
      Yoshinori Matsuwaki
    • Organizer
      American Academy Of Allergy Asthma & Immunology, 2011 Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 鼻茸中の真菌および黄色ブドウ球菌由来エンテロトキシン特異的IgE抗体の役割について2010

    • Author(s)
      松脇由典
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京国際フォーラム、東京都
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 好酸球性鼻副鼻腔炎のCT画像診断の検討2010

    • Author(s)
      荻野展広
    • Organizer
      日本医学放射線学会秋季臨床大会
    • Place of Presentation
      パシフィコ横浜,横浜市
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 鼻副鼻腔領域の内視鏡治療2010

    • Author(s)
      松脇由典
    • Organizer
      日本医学放射線学会秋季臨床大会
    • Place of Presentation
      パシフィコ横浜,横浜市
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] アレルギー性真菌性副鼻腔炎(AFRS)の術後経過の特徴2010

    • Author(s)
      柳清
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 好酸球性副鼻腔炎の診断基準に関する検討2010

    • Author(s)
      中山次久
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 環境真正担子菌(キノコ)によるアレルギー性真菌性副鼻腔炎の検討2010

    • Author(s)
      岩崎聖子
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性副鼻腔炎におけるCT staging systemの精度についての検討2010

    • Author(s)
      大櫛哲史
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性副鼻腔炎術後の自覚症状、QOL調査について2010

    • Author(s)
      吉田拓人
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 亜急性侵襲性副鼻腔真菌症の2症例2010

    • Author(s)
      原山幸久
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「Open Essence」および「日常のにおいアンケート」の臨床的有用性について2010

    • Author(s)
      森恵莉
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性副鼻腔炎術後急性増悪に対するアジスロマイシン成人用ドライシロップの有用性の検討2010

    • Author(s)
      浅香大也
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性鼻副鼻腔炎の病態と治療2010

    • Author(s)
      松脇由典
    • Organizer
      第49回日本鼻科学会総会ならびに学術講演会
    • Place of Presentation
      札幌コンベンションセンター、札幌市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sinobronchial Allergic Mycosis Syndrome(SAM症候群)の一症例からみる呼吸器内科と耳鼻咽喉科の協力の必要性2010

    • Author(s)
      大村和弘
    • Organizer
      アレルギー臨床懇話会
    • Place of Presentation
      慈恵医大、港区
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蝶形骨洞周辺頭蓋底疾患に対する鼻中隔粘膜弁を用いた2 hole 1 cavity surgeryの有用性について2010

    • Author(s)
      松脇由典
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台国際センター、仙台市
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 好酸球性鼻副鼻腔炎・アレルギー性真菌性鼻副鼻腔炎の有病率の検討2010

    • Author(s)
      中山次久
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台国際センター、仙台市
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上顎洞性後鼻孔ポリープの臨床的検討2010

    • Author(s)
      浅香大也
    • Organizer
      第111回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      仙台国際センター、仙台市
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Predictors of Olfactory Dysfunction after Endoscopic Sinus Surgery (ESS) in Patients with Chronic Rhinosinusitis, Part II2010

    • Author(s)
      Yoshinori Matsuwaki
    • Organizer
      23rd Congress of the European Rhinologic Society (ERS) and the 29th International Symposium of Infection and allergy of the Nose (ISIAN)
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2010 Annual Research Report
  • [Book] EBM 耳鼻咽喉科・頭頸部外科の治療 好酸球性副鼻腔炎における真菌の関与2010

    • Author(s)
      松脇由典, 他
    • Total Pages
      525
    • Related Report
      2012 Final Research Report
  • [Book] EBM耳鼻咽喉科・頭頸部外科の治療 好酸球性副鼻腔炎における真菌の関与2010

    • Author(s)
      松脇由典, 他
    • Total Pages
      525
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://kaken.nii.ac.jp/d/r/60287290

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2023-03-16  

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