| Project/Area Number |
22591905
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Yamagata University |
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Principal Investigator |
OHTA Nobuo 山形大学, 医学部, 講師 (20282212)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KURAKAMI Kazuya 山形大学, 医学部, 助教 (30571640)
FURUKAWA Takatoshi 山形大学, 医学部, 助教 (80466630)
SUZUKI Yusuke 山形大学, 医学部, 助教 (50466629)
KUBOTA Toshinori 山形大学, 医学部, 助教 (80536954)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | IgG4関連疾患 / ペリオスチン / Th17 / Th1 / Tc1 / IgG4硬化性疾患 / Tｃ１ / IL-17 / ぺリオスチン / ステロイド / 唾液腺 / 自己免疫性膵炎 / ペンドリ / ペンドリン |
|---|
| Research Abstract |
IgG4-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or IL-17 in this disease. The purpose of this study was to evaluate the characteristics of CD4+ and CD8+ T cells and IL-17 in patients with IgG4-related sclerosing sialadenitis. Our findings revealed a predominance of Th1 and Tc1 cells and overexpression of IL-17 in patients with IgG4-related sclerosing sialadenitis. This observation emphasizes the involvement of Th1 and Tc1 cells and IL-17 in the pathogenesis of this disease. Identify their precise functional properties would greatly enhance our understanding of their pathogenetic roles. A detailed phenotypic and functional analysis of these subsets is warranted.
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