The study of pathogenesis and related molecules of IgG4 related disease and development of treatment modality.
Project/Area Number |
22591905
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Yamagata University |
Principal Investigator |
OHTA Nobuo 山形大学, 医学部, 講師 (20282212)
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Co-Investigator(Kenkyū-buntansha) |
KURAKAMI Kazuya 山形大学, 医学部, 助教 (30571640)
FURUKAWA Takatoshi 山形大学, 医学部, 助教 (80466630)
SUZUKI Yusuke 山形大学, 医学部, 助教 (50466629)
KUBOTA Toshinori 山形大学, 医学部, 助教 (80536954)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | IgG4関連疾患 / ペリオスチン / Th17 / Th1 / Tc1 / IgG4硬化性疾患 / Tc1 / IL-17 / ぺリオスチン / ステロイド / 唾液腺 / 自己免疫性膵炎 / ペンドリ / ペンドリン |
Research Abstract |
IgG4-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or IL-17 in this disease. The purpose of this study was to evaluate the characteristics of CD4+ and CD8+ T cells and IL-17 in patients with IgG4-related sclerosing sialadenitis. Our findings revealed a predominance of Th1 and Tc1 cells and overexpression of IL-17 in patients with IgG4-related sclerosing sialadenitis. This observation emphasizes the involvement of Th1 and Tc1 cells and IL-17 in the pathogenesis of this disease. Identify their precise functional properties would greatly enhance our understanding of their pathogenetic roles. A detailed phenotypic and functional analysis of these subsets is warranted.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] NMDAreceptor-mediated Ca(2+) influxtriggers nucleoctoplasmictranslocation of diacylglycerol kinaseζ under oxygen-glucose deprivationconditions, an in vitro model of ischemia, in rat hippocampal slices2012
Author(s)
Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fuji S, Goto K
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Journal Title
Histchem Cell Biol
Volume: 137
Pages: 499-511
Related Report
Peer Reviewed
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[Presentation] IgG4関連硬化性疾患患者のTh1,Th2,Tc1,Tc2細胞および IL-172012
Author(s)
太田伸男,倉上和也 ,牧原靖一郎 ,岡野光博 ,石田晃弘,鈴木祐輔,欠畑誠治
Organizer
第30回日本耳鼻咽喉科免疫アレルギー学会
Place of Presentation
琵琶湖ホテル ,大津
Year and Date
2012-02-18
Related Report
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[Presentation] IgG4関連疾患の合併症に関する検討2012
Author(s)
倉上和也,太田伸男,石田晃弘,稲村和俊 ,鈴木祐輔 ,古川孝俊 ,欠畑誠治
Organizer
第30回日本耳鼻咽喉科免疫アレルギー学会
Place of Presentation
琵琶湖ホテル ,大津
Year and Date
2012-02-18
Related Report
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